3-methoxy-6-[4-(3-methylphenyl)-1-piperazinyl]pyridazine | 100241-46-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3-methoxy-6-[4-(3-methylphenyl)-1-piperazinyl]pyridazine
• 英文别名: 3-methoxy-6-[4-(3-methylphenyl)piperazin-1-yl]pyridazine
• CAS: 100241-46-1
• 化学式: C₁₆H₂₀N₄O
• 分子量: 284.361
• InChiKey: DDOAUTHWSCUHQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  41.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-chloro-6-[4-(3-methylphenyl)-1-piperazinyl]pyridazine 在 sodium methylate 、 sodium 作用下， 以 甲醇 、 氯仿 、 水 为溶剂， 以2 parts (50%)的产率得到3-methoxy-6-[4-(3-methylphenyl)-1-piperazinyl]pyridazine
  参考文献：
  名称：

  Anti-virally active pyridazinamines

  摘要：

  抗病毒活性吡啶并胺，含有该物质的组合物以及治疗温血动物病毒性疾病的方法。

  公开号：

  US05001125A1

文献信息

• Heterocyclic Derivatives and Their Use as Strearoyl-Coa Desaturase Inhibitors
  申请人：Kamboj Rajender

  公开号：US20080125434A1

  公开（公告）日：2008-05-29

  Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, W, R 2 , R 3 , R 5 , R 5a , R 6 , R 6a , R 7 , R 7a , R 8 and R 8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

  本发明揭示了一种治疗哺乳动物（优选为人类）SCD介导的疾病或病症的方法，其中该方法包括向需要治疗的哺乳动物施用化合物I的方法：其中x、y、G、J、K、L、M、W、R2、R3、R5、R5a、R6、R6a、R7、R7a、R8和R8a在此定义。本发明还揭示了包含化合物I的药物组合物。
• HETEROCYCLIC DERIVATIVES AND THEIR USE AS STEAROYL-COA DESATURASE INHIBITORS
  申请人：Kamboj Rajender

  公开号：US20090306090A1

  公开（公告）日：2009-12-10

  Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, W, R 2 , R 3 , R 5 , R 5a , R 6 , R 6a , R 7 , R 7a , R 8 and R 8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

  本发明涉及用于治疗哺乳动物，尤其是人体中SCD介导的疾病或病况的方法，其中所述方法包括向需要治疗的哺乳动物中给予化合物(I)的组合物，其中x、y、G、J、K、L、M、W、R2、R3、R5、R5a、R6、R6a、R7、R7a、R8和R8a在此定义。还公开了含有化合物(I)的制药组合物。
• Novel derivatives of gamma-cyclodextrin
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0197571A2

  公开（公告）日：1986-10-15

  Novel γ-cyclodextrin derivatives which are γ-cyclodextrin substituted with C1-C6 alkyl, hydroxy C1-C6 alkyl, carboxy C1-C6 alkyl or C1-C6 alkyloxycarbonylC,-C6 alkyl or mixed ethers thereof and their preparation. Compositions comprising such cyclodextrin derivatives and an active ingredient which is preferably a drug and the preparation of such compositions.

  用C1-C6烷基、羟基C1-C6烷基、羧基C1-C6烷基或C1-C6烷氧羰基C,-C6烷基或其混合醚取代的γ-环糊精新型衍生物及其制备方法。由此类环糊精衍生物和活性成分（最好是药物）组成的组合物及其制备方法。
• Method for depositing metal particles on a marker
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0293947A1

  公开（公告）日：1988-12-07

  An improved method for depositing metal particles on a marker which catalyzes the reduction of metal ions from a physical developer comprising a solution of metal ions, a molar excess of complexant in respect to the metal ions and a reducing agent. Said method being preferably employed for the detection of one or more components of an aggregate formed between a least one specific binding agent and its corresponding bindable substance by labelling at least one component of said aggregate with a marker and contacting said aggregate with a physical developer, whereby under influence of the marker a metal particle is formed which can be detected. Further the invention also relates to solutions and test-kits suited for carrying out the above mentioned method.

  一种在标记物上沉积金属颗粒的改进方法，该标记物可催化金属离子从物理显影剂中还原，物理显影剂包括金属离子溶液、相对于金属离子摩尔过量的络合剂和还原剂。本发明优选用于检测至少一种特异性结合剂与其相应的可结合物质之间形成的聚合体的一种或多种成分，方法是用标记物标记所述聚合体的至少一种成分，并将所述聚合体与物理显影剂接触，在标记物的影响下形成可检测的金属颗粒。此外，本发明还涉及适用于实施上述方法的溶液和测试套件。
• Antiviral pharmaceutical compositions containing cyclodextrins
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0300526A2

  公开（公告）日：1989-01-25

  An antiviral composition for administration to a mammal, in particular, intranasally, i.a. for the treatment of the common cold by control of common rhinoviruses. The composition is an inclusion complex of a cyclodextrin, e.g. an α-, β- or γ-cyclodextrin or derivatives thereof and an antiviral agent.

  一种抗病毒组合物，用于哺乳动物，特别是鼻内给药，即通过控制普通鼻病毒来治疗普通感冒。该组合物是环糊精（如 α-、β- 或 γ-环糊精或其衍生物）与抗病毒剂的包合物。