[(3R,6R)-6-甲基哌啶-3-基]甲醇盐酸盐 | 1088993-98-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: [(3R,6R)-6-甲基哌啶-3-基]甲醇盐酸盐
• 英文名称: ((3R,6R)-6-methylpiperidin-3-yl)-methanol
• 英文别名: [(6R)-6-methylpiperidin-3-yl]methanol；((3R,6R)-6-Methylpiperidin-3-YL)methanol；[(3R,6R)-6-methylpiperidin-3-yl]methanol
• CAS: 1088993-98-9
• 化学式: C₇H₁₅NO
• 分子量: 129.202
• InChiKey: FMYGWFUUVQICDN-RNFRBKRXSA-N

物化性质

• 沸点：
  207.4±13.0 °C(Predicted)
• 密度：
  0.915±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [(3R,6R)-6-甲基哌啶-3-基]甲醇盐酸盐 在 甲醇 、 lithium hydroxide 、 水 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 (2-(2H-1.2.3-triazol-2-yl)phenyl )((2R,5R)-5-(hydroxymethyl)-2-methylpiperidin-1-yl)methanone
  参考文献：
  名称：

  WO2008/147518

  摘要：

  公开号：
• 作为产物：
  描述：

  (6-甲基哌啶-3-基)甲醇 在 palladium(II) hydroxide/carbon 氢气 、 三乙胺 作用下， 以 甲醇 、 乙醇 、 正己烷 、 二氯甲烷 为溶剂， 生成 [(3R,6R)-6-甲基哌啶-3-基]甲醇盐酸盐
  参考文献：
  名称：

  WO2008/147518

  摘要：

  公开号：

文献信息

• [EN] PROCESS FOR THE PREPARATION OF AN OREXIN RECEPTOR ANTAGONIST<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN ANTAGONISTE DES RÉCEPTEURS DE L'OREXINE
  申请人：MERCK & CO INC

  公开号：WO2009143033A1

  公开（公告）日：2009-11-26

  The present invention is directed to processes for preparing a pyridyl piperidine compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved.

  本发明涉及制备吡啶基哌啶化合物的方法，该化合物是俄雷昔腺受体的拮抗剂，对治疗或预防涉及俄雷昔腺受体的神经和精神障碍和疾病具有用处。
• [EN] OXAZOLE OREXIN RECEPTOR ANTAGONISTS<br/>[FR] COMPOSÉS OXAZOLE ANTAGONISTES DES RÉCEPTEURS D'OREXINE
  申请人：MERCK SHARP & DOHME

  公开号：WO2015018029A1

  公开（公告）日：2015-02-12

  The present invention is directed to oxazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the oxazole compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及氧唑化合物，其为促进睡眠的受体拮抗剂。本发明还涉及所述氧唑化合物在潜在治疗或预防涉及促进睡眠的神经和精神障碍和疾病中的用途。本发明还涉及包含这些化合物的药物组合物。本发明还涉及这些药物组合物在预防或治疗涉及促进睡眠的疾病中的用途。
• [EN] OXAZOLE OREXIN RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DE RÉCEPTEUR D'OREXINE À BASE D'OXAZOLE
  申请人：MERCK SHARP & DOHME

  公开号：WO2015020930A1

  公开（公告）日：2015-02-12

  The present invention is directed to oxazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the oxazole compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及氧唑化合物，其为促进素受体的拮抗剂。本发明还涉及所述氧唑化合物在潜在的治疗或预防涉及促进素受体的神经和精神障碍和疾病中的用途。本发明还涉及包含这些化合物的药物组合物。本发明还涉及这些药物组合物在预防或治疗涉及促进素受体的疾病中的用途。
• [EN] PIPERIDINE ISOXAZOLE AND ISOTHIAZOLE OREXIN RECEPTOR ANTAGONISTS<br/>[FR] COMPOSÉS PIPÉRIDINES ISOXAZOLES ET ISOTHIAZOLES ANTAGONISTES DES RÉCEPTEURS DE L'OREXINE
  申请人：MERCK SHARP & DOHME

  公开号：WO2016065585A1

  公开（公告）日：2016-05-06

  The present invention is directed to piperidine isoxazole and isothiazole orexin compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及对脑嗜睡肽受体的拮抗剂——哌啶异噁唑和异噻唑化合物。本发明还涉及所述化合物在潜在的治疗或预防涉及脑嗜睡肽受体的神经和精神障碍和疾病中的用途。本发明还涉及包含这些化合物的组合物。本发明还涉及这些组合物在预防或治疗涉及脑嗜睡肽受体的疾病中的用途。
• [EN] 2,5-DISUBSTITUTED PIPERIDINE OREXIN RECEPTOR ANTAGONISTS<br/>[FR] PIPÉRIDINES 2,5-DISUBSTITUÉES COMME ANTAGONISTES DU RÉCEPTEUR DE L'OREXINE
  申请人：MERCK SHARP & DOHME

  公开号：WO2010048010A1

  公开（公告）日：2010-04-29

  The present invention is directed to 2,5-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及2,5-二取代哌啶酰胺化合物，这些化合物是促进睡眠的受体拮抗剂，可用于治疗或预防神经系统和精神疾病，以及涉及促进睡眠的疾病。该发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在预防或治疗涉及促进睡眠的疾病中的用途。