(7S-cis)-7-((3-Amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-(hydroxyacetyl)-5,12-naphthacenedione | 62348-68-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 蒽环类药物
• 英文名称: (7S-cis)-7-((3-Amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-(hydroxyacetyl)-5,12-naphthacenedione
• 英文别名: (7S,9S)-7-[(2R,4S,5R,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-8,10-dihydro-7H-tetracene-5,12-dione
• CAS: 62348-68-9
• 化学式: C₂₆H₂₇NO₁₀
• 分子量: 513.5
• InChiKey: XVXGYZFARCOVHS-LHFQILNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  37
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  197
• 氢给体数：
  6
• 氢受体数：
  11

文献信息

• Anticancer drug conjugates
  申请人：Ariel Scientific Innovations Ltd.

  公开号：US11007271B2

  公开（公告）日：2021-05-18

  Provided herein is a conjugate comprising two residues of structurally and/or mechanistically different anticancer bioactive agents, coupled to one another by a biocleavable linking moiety, as well as methods of treating cancer using the same and pharmaceutical compositions comprising the same.

  本文提供了一种共轭物，该共轭物由结构和/或机理上不同的抗癌生物活性剂的两个残基组成，通过可生物裂解的连接分子彼此偶联，还提供了使用该共轭物治疗癌症的方法以及包含该共轭物的药物组合物。
• ANTICANCER DRUG CONJUGATES
  申请人：Ariel Scientific Innovations Ltd.

  公开号：US20190224328A1

  公开（公告）日：2019-07-25

  Provided herein is a conjugate comprising two residues of structurally and/or mechanistically different anticancer bioactive agents, coupled to one another by a biocleavable linking moiety, as well as methods of treating cancer using the same and pharmaceutical compositions comprising the same.