1-Hydroxynaphthalene-2-diazonium

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-Hydroxynaphthalene-2-diazonium
• 化学式: C10H7N2O+
• 分子量: 171.17
• InChiKey: URQUNWYOBNUYJQ-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  48.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Detecting targets using mass tags and mass spectrometry
  申请人：Ventana Medical Systems, Inc.

  公开号：US10078083B2

  公开（公告）日：2018-09-18

  Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section.

  本文所公开的具体实施方案涉及使用一种或多种不同的质量标记，通过直接或间接的酶催化转化特异性地沉积在靶标上，从而提供一种识别组织样本中靶标的方法。质量标签可以用稳定同位素标记，以产生化学结构相同但质量不同的质量标签。通过电离质量标签产生的质量代码可使用质谱法进行检测和/或定量。该方法可用于特定样品中多个目标的多重检测。在某些实施方案中，可制备代表组织样本切片的切片图，切片图包括与定量数据相对应的数据，其中质量峰的大小被确定并与相应组织样本切片的靶标量相关联。
• DETECTING TARGETS USING MASS TAGS AND MASS SPECTROMETRY
  申请人：Ventana Medical Systems, Inc.

  公开号：EP2588144A2

  公开（公告）日：2013-05-08
• US9291597B2
  申请人：——

  公开号：US9291597B2

  公开（公告）日：2016-03-22
• [EN] DETECTING TARGETS USING MASS TAGS AND MASS SPECTROMETRY<br/>[FR] DÉTECTION DE MATIÈRES CIBLES À L'AIDE DE MARQUEURS DE MASSE ET D'UNE SPECTROMÉTRIE DE MASSE
  申请人：VENTANA MED SYST INC

  公开号：WO2012003478A2

  公开（公告）日：2012-01-05

  Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section.