Emetan, 2,3-didehydro-6',7',10,11-tetramethoxy-, dihydrochloride | 14358-43-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: Emetan, 2,3-didehydro-6',7',10,11-tetramethoxy-, dihydrochloride
• 英文别名: (11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-4,6,7,11b-tetrahydro-1H-benzo[a]quinolizine;dihydrochloride
• CAS: 14358-43-1；2228-39-9
• 化学式: C29H40Cl2N2O4
• 分子量: 551.5
• InChiKey: WNJZDNXVVDNPSI-FJEGXLQFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.85
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  52.2
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents
  申请人：Centre National de la Recherche Scientifique

  公开号：EP2505583A1

  公开（公告）日：2012-10-03

  Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and their use as antimalarial or antischistosomal agents.

  萘醌、氮杂萘醌和苯基蒽醌，它们的合成过程及其作为抗疟疾或抗血吸虫药剂的用途。
• [EN] TOTAL SYNTHESIS OF REDOX-ACTIVE 1.4-NAPHTHOQUINONES AND THEIR METABOLITES AND THEIR THERAPEUTIC USE AS ANTIMALARIAL AND SCHISTOMICIDAL AGENTS<br/>[FR] SYNTHÈSE TOTALE DE 1,4-NAPHTOQUINONES PRÉSENTANT UNE ACTIVITÉ D'OXYDO-RÉDUCTION ET DE LEURS MÉTABOLITES ET LEUR UTILISATION THÉRAPEUTIQUE COMME AGENTS ANTIPALUDIQUES ET SCHISTOMICIDES
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2012131010A1

  公开（公告）日：2012-10-04

  Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and their use as antimalarial or antischistosomal agents.

  萘醌、氮杂萘醌和苯基蒽醌，它们的合成过程以及它们作为抗疟疾或抗血吸虫药物的用途。
• TOTAL SYNTHESIS OF REDOX-ACTIVE 1.4-NAPHTHOQUINONES AND THEIR METABOLITES AND THEIR THERAPEUTIC USE AS ANTIMALARIAL AND SCHISTOMICIDAL AGENTS
  申请人：Davioud-Charvet Elisabeth

  公开号：US20140121238A1

  公开（公告）日：2014-05-01

  Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and methods of their use as antimalarial or antischistosomal agents.

  萘醌，氮杂萘醌和苯并蒽醌，它们的合成过程及其作为抗疟疾或抗血吸虫药物的使用方法。
• Use of multiple recombination sites with unique specificity in recombinational cloning
  申请人：INVITROGEN CORPORATION

  公开号：EP1978098A2

  公开（公告）日：2008-10-08

  The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites with unique specificity The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the molecules are inserted into distinct sites in a vector. The invention also generally provides for linking or joining through recombination a number of molecules and/or compounds (eg, chemical compounds, drugs, proteins or peptides, lipids, nucleic acids, carbohydrates, etc) which may be the same or different Such molecules and/or compounds or combinations of such molecules and/or compounds can also be bound through recombination to various structures or supports according to the invention.

  本发明提供了用于重组克隆的组合物和方法。这些组合物包括具有多个独特特异性重组位点的载体，这些方法允许同时克隆两个或多个不同的核酸分子。在某些实施方案中，分子被融合在一起，而在其他实施方案中，分子被插入载体中的不同位点。本发明一般还提供了通过重组连接或接合一些分子和/或化合物（例如，化合物、药物、蛋白质或肽、脂质、核酸、碳水化合物等）的方法，这些分子和/或化合物可以是相同的，也可以是不同的。 根据本发明，这些分子和/或化合物或其组合也可以通过重组结合到各种结构或支架上。
• DRUG DELIVERY USING TERMINAL COMPLEMENT COMPONENTS
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：EP0932420A1

  公开（公告）日：1999-08-04