4-(3,4-dihydro-1H-isoquinolin-2-ylsulfonyl)benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 4-(3,4-dihydro-1H-isoquinolin-2-ylsulfonyl)benzamide
• 化学式: C₁₆H₁₆N₂O₃S
• 分子量: 316.4
• InChiKey: IJOVXRWQKSEVFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  88.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• MASSIVELY PARALLEL DISCOVERY METHODS FOR OLIGONUCLEOTIDE THERAPEUTICS
  申请人：Roche Innovation Center Copenhagen A/S

  公开号：US20210071247A1

  公开（公告）日：2021-03-11

  The invention relates to the field of therapeutic oligonucleotide analytics and discovery, and provides methods for primer based parallel sequencing of modified oligonucleotides which provide sequence based quality information which may be used in oligonucleotide therapeutic discovery, manufacture, quality assurance, therapeutic development, and patient monitoring.
• SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF
  申请人：Sanford Burnham Prebys Medical Discovery Institute

  公开号：US20210161873A1

  公开（公告）日：2021-06-03

  Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.
• QUALITY CONTROL OF LNA OLIGONUCLEOTIDE THERAPEUTICS USING MASSIVELY PARALLEL SEQUENCING
  申请人：ROCHE INNOVATION CENTER COPENHAGEN A/S

  公开号：US20220002796A1

  公开（公告）日：2022-01-06

  The invention relates to the field of therapeutic oligonucleotide analytics, and provides methods for primer based parallel sequencing of therapeutic oligonucleotides which provide sequence based quality information which may be used in conjunction with or in place of present chromatography or mass spectroscopic methods, and may be used, for example, in oligonucleotide therapeutic discovery, manufacture, quality assurance, therapeutic development, and patient monitoring.