3-Aminonaphthalene-1,2-dicarboxylic acid | 396100-84-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-Aminonaphthalene-1,2-dicarboxylic acid
• CAS: 396100-84-8
• 化学式: C₁₂H₉NO₄
• 分子量: 231.2
• InChiKey: VQUIWLHMFOYFHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• METHOD FOR PRODUCING A PURIFIED NAPHTHALENE DICARBOXYLIC ACID
  申请人：Kurashima Hideharu

  公开号：US20140200364A1

  公开（公告）日：2014-07-17

  A method for producing a purified naphthalenedicarboxylic acid includes steps of mixing a naphthalenedicarboxylic acid-containing material and an amine in a mixed liquid of water and an organic solvent to give a crystal of a naphthalenedicarboxylic acid amine salt; and obtaining a purified naphthalenedicarboxylic acid from the crystal of the naphthalenedicarboxylic acid amine salt, wherein (1) in the step of forming the naphthalenedicarboxylic acid amine salt by adding an amine to the slurry that contains water, an organic solvent and a naphthalenedicarboxylic acid, the amine addition rate is from 0.002 to 0.4 mol/min relative to one mol of the naphthalenedicarboxylic acid, or (2) an amine is added to the aqueous solution prepared by dissolving the naphthalenedicarboxylic acid amine salt in water, or to the liquid prepared through solid-liquid separation of the aqueous solution to insolubilize and precipitate the metal component, and the precipitated metal component is removed through solid-liquid separation.

  一种生产纯化萘二甲酸的方法，包括以下步骤：将含有萘二甲酸的材料和胺混合在水和有机溶剂的混合液中，得到萘二甲酸胺盐的晶体；从萘二甲酸胺盐的晶体中获取纯化的萘二甲酸，其中（1）在将胺加入含有水、有机溶剂和萘二甲酸的浆料中形成萘二甲酸胺盐的步骤中，胺的加入速率相对于一摩尔萘二甲酸为0.002至0.4摩尔/分钟，或（2）将胺加入通过将萘二甲酸胺盐溶解在水中制备的水溶液或通过固液分离制备的液体中，使金属组分不溶解和沉淀，然后通过固液分离去除沉淀的金属组分。
• Purification Method of Crude Naphthalene Dicarboxylic Acid Using Microorganism and 2,6-Naphthalene Dicarboxylic Acid in Crystalline Form Obtained by Using the Same
  申请人：Kim Dong Sung

  公开号：US20100063318A1

  公开（公告）日：2010-03-11

  Disclosed is a method for purifying a crude naphthalene dicarboxylic acid using microorganism. According to the purification method, a crude naphthalene dicarboxylic acid is purified by reacting a microorganism having the ability to convert 2-formyl-6-naphthoic acid to 2,6-naphthalene dicarboxylic acid with a crude naphthalene dicarboxylic acid, adding an acidic solution to the reaction solution under particular conditions, stirring the mixed solution to crystallize the crude naphthalene dicarboxylic acid, washing the crystallized crude naphthalene dicarboxylic acid, and drying the washed product to obtain 2,6-naphthalene dicarboxylic acid in a pure crystalline form. Advantageously, the purification method enable production of high-purity crystalline 2,6-naphthalene dicarboxylic acid on an industrial scale in an environmentally friendly manner.

  本发明公开了一种利用微生物纯化粗萘二羧酸的方法。根据该纯化方法，通过将具有将2-甲酰基-6-萘甲酸转化为2,6-萘二羧酸能力的微生物与粗萘二羧酸反应，将酸性溶液加入到特定条件下的反应溶液中，搅拌混合溶液以结晶粗萘二羧酸，清洗结晶的粗萘二羧酸，并将洗涤后的产物干燥以获得纯结晶形式的2,6-萘二羧酸。优点是，该纯化方法可以在环保的条件下在工业规模上生产高纯度的2,6-萘二羧酸晶体。
• Process for producing naphtalenedicarboxylic acid
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：EP0551596A2

  公开（公告）日：1993-07-21

  A process for purifying a crude naphthalenedicarboxylic acid containing impurities and coloring substances obtained by the oxidation of a di-substituted naphthalene, dispense with the use of a large amount of alkali or acid, and producing a naphthalenedicarboxylic acid having a high purity and good color effectively and in a high recovery is disclosed, which comprises dissolving the crude naphthalenedicarboxylic acid in a mixed solvent comprising an amine compound and an alcohol and conducting crystallization.

  本发明公开了一种用于提纯含有杂质和着色物质的粗萘二甲酸的工艺，这种杂质和着色物质是通过氧化二取代萘获得的，无需使用大量的碱或酸，即可生产出纯度高、着色好、回收率高的萘二甲酸，该工艺包括将粗萘二甲酸溶解在由胺化合物和醇组成的混合溶剂中并进行结晶。
• QUINAZOLINE DERIVATIVES AND USE THEREOF
  申请人：SUNTORY LIMITED

  公开号：EP0795548A1

  公开（公告）日：1997-09-17

  A chymase inhibitor containing as its effective ingredient a quinazoline derivative, or a pharmaceutically acceptable salt thereof, having the formula (1): and a pharmaceutical preparation for the prevention of cardiac and circulatory system diseases derived from abnormal exacerbation of Ang II production containing the same as its effective ingredient.

  一种糜蛋白酶抑制剂，其有效成分含有式（1）的喹唑啉衍生物或其药学上可接受的盐： 以及一种用于预防因血管紧张素 II 生成异常增加而引起的心脏和循环系统疾病的药物制剂，其有效成分也包含上述成分。
• METHOD FOR PRODUCING ORGANIC COMPOUND
  申请人：Unitika Ltd.

  公开号：EP3819283A1

  公开（公告）日：2021-05-12

  The present invention provides a production method of an organic compound, in which a reaction is performed between functional groups without using any solvents. The present invention relates to a production method of an organic compound, in which a reaction is performed between functional groups by using a mechanochemical effect.

  本发明提供了一种有机化合物的生产方法，其中官能团之间的反应是在不使用任何溶剂的情况下进行的。本发明涉及一种有机化合物的生产方法，其中官能团之间的反应是通过机械化学效应进行的。