2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol;(E)-N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol;(E)-N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine
• 化学式: C34H37F2N7O
• 分子量: 597.7
• InChiKey: JVSLBTFXXCPNNF-SZKNIZGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.61
• 重原子数：
  44
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  84.9
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• USE OF A SILICA OR SILICA DERIVATIVE AS A SORPTION MATERIAL
  申请人：LifeCycle Pharma A/S

  公开号：EP1601347A1

  公开（公告）日：2005-12-07
• [EN] USE OF A SILICA OR SILICA DERIVATIVE AS A SORPTION MATERIAL<br/>[FR] UTILISATION DE SILICE OU D'UN DERIVE DE SILICE EN TANT QUE MATERIAU DE SORPTION
  申请人：LIFECYCLE PHARMA AS

  公开号：WO2004073689A1

  公开（公告）日：2004-09-02

  Use of a silica or silica derivative such as, e.g., Aeroperl® as a sorption material for oils or oily-like materials. The silica or silica derivates has the ability to be loaded with a relative high amount of the oil or oily-like material and this ability is especially useful concerning formulation of pharmaceutical compositions comprising a drug substance suffering from e.g. bioavailability and/or water-solubility problems. Furthermore, the silica or silica derivative has the ability to release the oil or oily-like material when contacted with an aqueous medium and/or it has suitable tabletting properties.