1,4-diethoxy-2,3-bis(hydroxymethyl)naphthalene | 59883-09-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1,4-diethoxy-2,3-bis(hydroxymethyl)naphthalene
• 英文别名: 1,4-Diethoxy-2,3-naphthalenedimethanol；[1,4-diethoxy-3-(hydroxymethyl)naphthalen-2-yl]methanol
• CAS: 59883-09-9
• 化学式: C₁₆H₂₀O₄
• 分子量: 276.332
• InChiKey: RVPPSRBFIGKZDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• BENZO'F!ISOINDOLE DERIVATIVES WITH AFFINITY TO THE EP4 RECEPTOR
  申请人：GLAXO GROUP LIMITED

  公开号：EP1368312A1

  公开（公告）日：2003-12-10
• BENZO[F]ISOINDOLE DERIVATIVES WITH AFFINITY TO THE EP4 RECEPTOR
  申请人：Glaxo Group Limited

  公开号：EP1886993B1

  公开（公告）日：2013-09-18
• [EN] BENZO'F!ISOINDOLE DERIVATIVES WITH AFFINITY TO THE EP4 RECEPTOR<br/>[FR] DERIVES DE BENZO(F)ISOINDOLE AYANT UNE AFFINITE POUR LE RECEPTEUR EP4
  申请人：GLAXO GROUP LTD

  公开号：WO2002064564A1

  公开（公告）日：2002-08-22

  A compound of formula (I) wherein R?1 and R3¿ are the same or different and represent =O, hydrogen, C¿1-6?alkyl, C1-6dialkyl, =CHC1-C5alkyl, =S, or a 5- or 6-membered anyl; R?4 to R9¿ are the same or different and represent hydrogen, C¿1-6?alkoxy, OCF3, OCH2CF3, O-cyclopropyl, OCH2-cyclopropyl, C1-C6alkyl, S-alkyl, NR210¿ where R10 is hydrogen or C¿1-6?alkyl, halogen, NO2, OH, CH2OC1-C6alkly, CH2OH, or CF3; Q?1¿ is hydrogen, C¿1-6? alkyl, C1-6dialkyl, C1-6alkoxy, NHAc, NR210¿ where R10 is hydrogen is hydrogen or C¿1-6?alkyl, difluoro, fluoro, =O, or OH; Q?2, Q3, Q4 and Q5¿ are the same or different and represent hydrogen, C¿1-6?alkoxy, OCF3, OCH2CF3, O-cyclopropyl, OCH2-cyclopropyl, C1-C6alkyl, S-alkyl, NR210¿ where R10 is hydrogen or C¿1-6?alkyl, halogen, NO2, OH, CH2OC1-C6alkyl, CH2OH, or a 5-or 6-membered aryl; with the proviso that the compounds [4-(1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]-2-propionic acid, sodium salt and [4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetic acid are excluded; and pharmaceutically acceptable derivatives thereof.