2,7,8-trimethyl-2-(β-carboxy-ethyl)-6-hydroxychroman | 53101-58-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2,7,8-trimethyl-2-(β-carboxy-ethyl)-6-hydroxychroman
• 英文别名: γ-CEHC；(+/-)-(6-hydroxy-2,7,8-trimethylchroman-2-yl) acetic acid；(6-Hydroxy-2,7,8-trimethyl-3,4-dihydro-2H-1-benzopyran-2-yl)acetic acid；2-(6-hydroxy-2,7,8-trimethyl-3,4-dihydrochromen-2-yl)acetic acid
• CAS: 53101-58-9
• 化学式: C₁₄H₁₈O₄
• 分子量: 250.295
• InChiKey: LQQSHBJXOPYWNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Method for producing optically active chroman-carboxylate
  申请人：Kyuuko Youichi

  公开号：US20060141591A1

  公开（公告）日：2006-06-29

  In the method for producing an optically active chromancarboxylate of the present invention, one of the enantiomers of racemic chromancarboxylic acid is esterified in a solvent containing an alcohol in the presence of a biocatalyst. After the esterification, the other enantiomer, i.e., the non-reacted chromancarboxylic acid is separated out of the reaction mixture to obtain the aimed optically active ester. The optically active chromancarboxylate is useful as the material for medicines, agricultural chemicals, etc. The invention provides an efficient production method thereof which is industrially applicable.

  本发明提供了一种制备光学活性的色环羧酸酯的方法，其中在含有醇的溶剂中，在生物催化剂的存在下，对外消旋色环羧酸的对映体之一进行酯化。酯化后，另一对映体即未反应的色环羧酸从反应混合物中分离出来，以获得目标的光学活性酯。光学活性的色环羧酸酯可用作药物、农药等材料。本发明提供了一种高效的工业应用的生产方法。
• METHOD FOR PRODUCING OPTICALLY ACTIVE CHROMAN-CARBOXYLATE
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：EP1634958A1

  公开（公告）日：2006-03-15

  In the method for producing an optically active chromancarboxylate of the present invention, one of the enantiomers of racemic chromancarboxylic acid is esterified in a solvent containing an alcohol in the presence of a biocatalyst. After the esterification, the other enantiomer, i.e., the non-reacted chromancarboxylic acid is separated out of the reaction mixture to obtain the aimed optically active ester. The optically active chromancarboxylate is useful as the material for medicines, agricultural chemicals, etc. The invention provides an efficient production method thereof which is industrially applicable.

  在本发明生产光学活性铬羧酸酯的方法中，外消旋铬羧酸的一种对映体在含有醇的溶剂中，在生物催化剂的存在下进行酯化反应。酯化后，从反应混合物中分离出另一种对映体，即未反应的铬羧酸，从而得到光学活性酯。具有光学活性的铬羧酸酯可用作药物、农药等的原料。本发明提供了一种适用于工业的高效生产方法。
• Hydroxyamines N-acyl derivatives having scavenger activity and useful in acute and chronic pathologies associated with peroxidation and inflammation phenomena
  申请人：LIFEGROUP S.p.A.

  公开号：EP0604995B1

  公开（公告）日：1998-09-30
• US3947473A
  申请人：——

  公开号：US3947473A

  公开（公告）日：1976-03-30
• US4003919A
  申请人：——

  公开号：US4003919A

  公开（公告）日：1977-01-18