N-[[(1R)-3,4-dihydro-1H-isochromen-1-yl]methyl]propan-1-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: N-[[(1R)-3,4-dihydro-1H-isochromen-1-yl]methyl]propan-1-amine
• 化学式: C₁₃H₁₉NO
• 分子量: 205.3
• InChiKey: ISFAVGAFLQHMJN-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• 1-heterocyclyl isochromanyl compounds and analogs for treating CNS disorders
  申请人：Sunovion Pharmaceuticals Inc.

  公开号：US10336732B2

  公开（公告）日：2019-07-02

  Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, Ra, R1, R2, R3, R4, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.

  公开的是式 (I) 化合物： 及其药学上可接受的盐类，其中 A、Ra、R1、R2、R3、R4、R6、w 和 n1 在本文中定义和描述；其组合物；及其使用方法。这些化合物可用于治疗各种神经和精神疾病，如本文所述的疾病。
• 1-HETEROCYCLYL ISOCHROMANYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS
  申请人：Sunovion Pharmaceuticals Inc.

  公开号：US20180093974A1

  公开（公告）日：2018-04-05

  Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, R a , R 1 , R 2 , R 3 , R 4 , R 6 , w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.