1-benzopyranylamine | 67747-72-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1-benzopyranylamine
• 英文别名: 2-aminobenzopyran；aminochromene；2H-1-Benzopyran-2-amine；2H-chromen-2-amine
• CAS: 67747-72-2
• 化学式: C₉H₉NO
• 分子量: 147.177
• InChiKey: ZGKVRYOUJKEBAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-benzopyranylamine 、 6-hydroxy-2,5,7,8-tetramethyl-2-(4-nitrophenoxymethyl)chroman-4-one 、 nitrochromene 在 molecular sieve 、 钯 作用下， 以 异丙醇 、 甲苯 为溶剂， 以75.1%的产率得到6-hydroxy-2,5,7,8-tetramethyl-2-(4-aminophenoxymethyl)chroman
  参考文献：
  名称：

  Process for the preparation of

  摘要：

  一种制备一般式为：##STR1##其中R是具有1到4个碳原子的低级烷基的氨基色酮的新工艺。在该工艺中，使用氧化锆/异丙醇还原一般式为：##STR2##的硝基色酮，以得到相应的氨基色酚和相应的硝基色酚的混合物。然后，在氢化催化剂的存在下，用氢气对混合物进行加氢，以得到最终产物。氨基色酮是制备降血脂药物的重要中间体。

  公开号：

  US05284961A1

文献信息

• [EN] METHODS FOR PREPARING AMIDE DERIVATIVES<br/>[FR] PROCÉDÉS DE PRÉPARATION DE DÉRIVÉS D'AMIDE
  申请人：PHARMACOSTECH CO LTD

  公开号：WO2010002075A1

  公开（公告）日：2010-01-07

  The present invention provides a novel method for preparing an amide derivative. The method of the present invention enables to economically prepare various amide derivatives containing pranlukart by reacting a carboxylic acid derivative 5 and an amine derivative through a brief procedure compared with a conventional technology, and permits to obtain a final product at a high yield rate because it is feasible to eliminate by-products after termination of reactions. Accordingly, the present method is to be quite suitable for massive production.

  本发明提供了一种制备酰胺衍生物的新方法。与传统技术相比，本发明的方法通过简短的程序，使得可以经济地制备含有普兰卢卡特的各种酰胺衍生物，通过反应羧酸衍生物5和胺衍生物，因为在反应终止后可以消除副产物，从而可以以高产率获得最终产品。因此，本方法非常适合大规模生产。
• Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
  申请人：Cytovia, Inc.

  公开号：US20030114485A1

  公开（公告）日：2003-06-19

  The present invention is directed to substituted coumarins and quinolines and analogs thereof, represented by the general Formula I: 1 wherein A, B, X, Y, and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

  本发明涉及取代香豆素和喹啉及其类似物，由一般式I：1表示，其中A、B、X、Y和Z在此处定义。本发明还涉及发现具有式I的化合物是caspase的激活剂和凋亡诱导剂。因此，本发明的caspase激活剂和凋亡诱导剂可用于诱导在出现异常细胞的不受控制的生长和传播的各种临床状况中的细胞死亡。
• 6-alkylamino-2,2'-disubstituted-7,8-disubstituted-2H-1-benzopyran derivatives as 5-lipoxygenase inhibitor
  申请人：Gong Young-Dae

  公开号：US20050203145A1

  公开（公告）日：2005-09-15

  When a multi-step process reaction is carried out in a solution, it generally requires several treatments and purification procedures to go through with after the reaction, however, the inventive method for preparing 2,2′-disubstituted-3,4-dihydro-7,8-disubstituted-6-amino benzopyran derivative using a solid-phased synthetic method simplifies the treatment and purification procedures after the reaction, which makes possible to efficiently construct numerous drug-like libraries. In particular, since the inventive method of the present invention comprises the steps of introducing a carbonate linker of formula 2 into Wang resin used as a common solid support (Step 1); synthesizing various benzopyran in a carbamate form of formula 3 as a key intermediate by reacting various amino benzopyran derivatives with the carbamate resin of formula 2 (Step 2); synthesizing 2,2′-disubstituted-3,4-2H-6-substituted benzopyran resin of formula 4 (Step 3); and synthesizing 2,2′-disubstituted-3,4-2H-6-alkylamino benzopyran derivative of formula 1 using a dichloromethane solution containing TFA or an organic solvent containing an organic acid, the inventive method is capable of efficiently synthesizing various 2,2′-disubstituted-3,4-2H-6-alkylamino benzopyran derivatives. Consequently, the present invention has developed a new technique for constructing 2,2′-disubstituted-3,4-2H-6-alkylamino benzopyran library using a solid-phase parallel synthetic method and makes increased the applicability of combinatorial chemical synthetic method. Further, 2,2′-disubstituted-3,4-2H-6-alkylamino benzopyran derivative prepared by the inventive method has a high inhibitory effect to 5-lipoxygenase (5-LO) activity, and therefore, can be effectively used for developing a new propylactic or therapeutic drug for leukotriene activation-related diseases such as chronic inflammation, rheumatic arthritis, colitis, asthma and psoriasis.

  当多步骤反应过程在溶液中进行时，通常需要进行几次处理和纯化程序才能完成反应后的步骤，然而，使用固相合成方法制备2,2'-二取代-3,4-二氢-7,8-二取代-6-氨基苯并吡喃衍生物的创新方法简化了反应后的处理和纯化程序，从而能够有效地构建大量类似药物的文库。特别是，由于本发明的创新方法包括以下步骤：将式2的碳酸酯连接体引入作为常见固体支持的Wang树脂中（步骤1）；通过将各种氨基苯并吡喃衍生物与碳酸酯树脂（式2）反应，合成各种以氨基甲酸酯形式（式3）为关键中间体的苯并吡喃（步骤2）；合成式4的2,2'-二取代-3,4-2H-6-取代苯并吡喃树脂（步骤3）；并使用含有三氟乙酸（TFA）的二氯甲烷溶液或含有有机酸的有机溶剂合成式1的2,2'-二取代-3,4-2H-6-烷基氨基苯并吡喃衍生物，该创新方法能够有效地合成各种2,2'-二取代-3,4-2H-6-烷基氨基苯并吡喃衍生物。因此，本发明已经开发了一种使用固相并行合成方法构建2,2'-二取代-3,4-2H-6-烷基氨基苯并吡喃文库的新技术，并增加了组合化学合成方法的适用性。此外，通过创新方法制备的2,2'-二取代-3,4-2H-6-烷基氨基苯并吡喃衍生物对5-脂氧酶（5-LO）活性具有高抑制作用，因此，可以有效用于开发用于治疗白三烯激活相关疾病（如慢性炎症、风湿性关节炎、结肠炎、哮喘和银屑病）的新型预防或治疗药物。
• [EN] GLYCOPROTEIN IIb/IIIa ANTAGONISTS<br/>[FR] ANTAGONISTES DE LA GLYCOPROTEINE IIb/IIIa
  申请人：ELI LILLY AND COMPANY

  公开号：WO1996022288A1

  公开（公告）日：1996-07-25

  (EN) This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, benzopyran, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.(FR) Cette invention se rapporte à certains composés bicycliques possédant un noyau constitué de deux cycles hexagonaux fusionnés, par exemple, benzopyrane, isoquinoline, isoquinolone, tétrahydronaphtalène, dihydronaphtalène ou tétralone, remplacés par une fonctionnalité à la fois basique et acide. Ces composés sont utilisés dans l'inhibition de l'agrégation plaquettaire.

  该发明涉及某些具有由两个融合的六元环组成的核的双环化合物，例如苯并吡喃、异喹啉、异喹啉酮、四氢萘、二氢萘或四酮，被基础和酸性官能团取代，可用于抑制血小板聚集。
• Process for producing aminobenzopyran compound
  申请人：Shimizu Takanori

  公开号：US20050192444A1

  公开（公告）日：2005-09-01

  There is provided a method for producing aminobenzopyran compound, which results in little wastes, has no influence on reactors and necessitates a simple work-up procedure. Concretely, it is a method for producing aminobenzopyran compound of formula (2) characterized by reducing a nitro group on 2,2-dimethyl 2H-1-benzopyran compound of formula (1) with hydrazine in the presence of a metal catalyst.

  提供一种生产氨基苯并吡喃化合物的方法，该方法产生少量废物，不会影响反应器，并需要简单的工作步骤。具体而言，它是一种通过在存在金属催化剂的情况下使用肼还原式(1)的2,2-二甲基2H-1-苯并吡喃化合物上的硝基团来生产式(2)的氨基苯并吡喃化合物的方法。