2,3-Diaminonaphthalene-1-sulfonic acid | 63285-24-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2,3-Diaminonaphthalene-1-sulfonic acid
• CAS: 63285-24-5
• 化学式: C₁₀H₁₀N₂O₃S
• 分子量: 238.27
• InChiKey: UQTAYOYMDOKOKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] ANTIBODY-POLYMER-DRUG CONJUGATES<br/>[FR] CONJUGUÉS ANTICORPS-POLYMÈRE-MÉDICAMENT
  申请人：UNIV UTAH RES FOUND

  公开号：WO2018071767A1

  公开（公告）日：2018-04-19

  Disclosed herein, are antibody-polymer-drug conjugates. The conjugate comprises a targeting moiety, one or more polymers, and one or more therapeutic agents. Also described herein, are compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本文披露了抗体-聚合物-药物共轭物。该共轭物包括一个靶向基团、一个或多个聚合物和一个或多个治疗剂。本文还描述了包含这些共轭物的组合物、它们的制备方法以及使用这些共轭物或其组合物治疗各种疾病的方法。本摘要旨在作为在特定领域搜索的扫描工具，并不打算限制本发明。
• Nucleic acid amplification
  申请人：——

  公开号：US20030228613A1

  公开（公告）日：2003-12-11

  Disclosed are compositions and methods for amplification of nucleic acid sequences of interest. It has been discovered that amplification reactions can produce amplification products of high quality, such as low amplification bias, if performed on an amount of nucleic acid at or over a threshold amount and/or on nucleic acids at or below a threshold concentration. The threshold amount and concentration can vary depending on the nature and source of the nucleic acids to be amplified and the type of amplification reaction employed. Disclosed is a method of determining the threshold amount and/or threshold concentration of nucleic acids that can be used with nucleic acid samples of interest in amplification reactions of interest. Because amplification reactions can produce high quality amplification products, such as low bias amplification products, below the threshold amount and/or concentration of nucleic acid, such below-threshold amounts and/or concentrations can be used in amplification reactions.

  本发明涉及一种扩增感兴趣核酸序列的组合物和方法。已经发现，如果在达到或超过阈值量的核酸上和/或在低于阈值浓度的核酸上进行扩增反应，则扩增反应可以产生高质量的扩增产物，例如低扩增偏差。阈值量和浓度可以根据要扩增的核酸的性质和来源以及所采用的扩增反应类型而有所不同。本发明揭示了一种确定阈值量和/或阈值浓度的核酸的方法，该方法可用于扩增感兴趣的核酸样品中的扩增反应。由于扩增反应可以在低于阈值量和/或浓度的核酸下产生高质量的扩增产物，例如低偏差扩增产物，因此可以在扩增反应中使用低于阈值量和/或浓度的核酸。
• Encapsulation of discrete quanta of fluorescent particles
  申请人：LUMINEX CORPORATION

  公开号：US20030132538A1

  公开（公告）日：2003-07-17

  The present invention provides novel encapsulation compositions and methods. In particular, the invention relates to fluorescent capsule compositions, which consists of a layer of a polymer shell enclosing one or more fluorescent materials such as fluorescent microspheres and which are capable of emitting at least two distinct fluorescent signals. Also provided are methods for their preparation. The compositions and methods of this invention are useful in a variety of applications, including preparation of multiplexed arrays for industrial, chemical, immunological, and genetic manipulation and analysis especially as related but not limited to flow cytometry.

  本发明提供了新型的封装组合物和方法。具体而言，本发明涉及荧光胶囊组合物，其由聚合物壳层包裹一个或多个荧光材料（如荧光微球），并能够发出至少两种不同的荧光信号。本发明还提供了它们的制备方法。本发明的组合物和方法在各种应用中有用，包括制备用于工业、化学、免疫和遗传操作和分析的多重阵列，特别是与流式细胞术相关但不限于此。
• FLUORESCENT POLYMERIC MATERIALS CONTAINING LIPID SOLUBLE RHODAMINE DYES
  申请人：LAM Joe Y.L.

  公开号：US20090072197A1

  公开（公告）日：2009-03-19

  Fluorescent polymeric materials are disclosed comprising a polymer and one or more lipid soluble rhodamine dyes. The materials are especially useful in the preparation of multicolored microparticles, especially multicolored polystyrene microparticle, for use in the multiplexed analysis of a plurality of analytes in a single sample. When excited by a light source, the materials give off a unique emission based on the nature, concentration and ratio of the dyes therein. Methods of preparing and using said materials are also disclosed.

  本发明披露了一种包括聚合物和一种或多种脂溶性罗丹明染料的荧光聚合物材料。该材料在制备多色微粒，特别是多色聚苯乙烯微粒方面特别有用，用于在单个样品中进行多重分析多种分析物。当受到光源的激发时，该材料会发出基于其中染料的性质、浓度和比例的独特发射。本发明还披露了制备和使用该材料的方法。
• NUCLEIC ACID AMPLIFICATION
  申请人：Bornarth Carole

  公开号：US20080128298A1

  公开（公告）日：2008-06-05

  Disclosed are compositions and methods for amplification of nucleic acid sequences of interest. It has been discovered that amplification reactions can produce amplification products of high quality, such as low amplification bias, if performed on an amount of nucleic acid at or over a threshold amount and/or on nucleic acids at or below a threshold concentration. The threshold amount and concentration can vary depending on the nature and source of the nucleic acids to be amplified and the type of amplification reaction employed. Disclosed is a method of determining the threshold amount and/or threshold concentration of nucleic acids that can be used with nucleic acid samples of interest in amplification reactions of interest. Because amplification reactions can produce high quality amplification products, such as low bias amplification products, below the threshold amount and/or concentration of nucleic acid, such below-threshold amounts and/or concentrations can be used in amplification reactions.

  本发明涉及一种扩增感兴趣的核酸序列的组合物和方法。已经发现，如果在等于或超过阈值数量的核酸或低于阈值浓度的核酸上进行扩增反应，则可以产生高质量的扩增产物，例如低扩增偏差。阈值数量和浓度取决于要扩增的核酸的性质和来源以及所采用的扩增反应类型。本发明还涉及一种确定可用于扩增感兴趣的核酸样品的阈值数量和/或阈值浓度的方法。由于扩增反应可以产生高质量的扩增产物，例如低偏差扩增产物，因此可以在低于阈值数量和/或浓度的核酸中使用这些低于阈值的数量和/或浓度进行扩增反应。