4-Bromocyclohexane-1,2-diamine | 90015-89-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: 4-Bromocyclohexane-1,2-diamine
• CAS: 90015-89-7
• 化学式: C₆H₁₃BrN₂
• 分子量: 193.08
• InChiKey: VRWNELWMABBYCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Modified labeled nucleotides and polynucleotides and methods of preparing, utilizing and detecting same
  申请人：ENZO BIOCHEM, INC.

  公开号：EP0097373A2

  公开（公告）日：1984-01-04

  Nucleotides and polynucleotides, including DNA, are chemically modified or labeled so as to be capable of ready detection when attached to and/or incorporated in nucleic acid material.

  核苷酸和多核苷酸（包括 DNA）经过化学修饰或标记，当附着在核酸材料上和/或掺入核酸材料中时，可随时进行检测。
• Detectable molecules, method of preparation and use
  申请人：ENZO BIOCHEM, INC.

  公开号：EP0154788A2

  公开（公告）日：1985-09-18

  A detectable molecule of the formula where A3 is A2 or a polymer, where A3 has at least one modifiable reactive group selected from the group consisting of amino, hydroxy, cis OH, halides, aryl, imidazoyi, carbonyl, carboxy, thiol or a residue comprising an activated carbon; -X- is selected from the group consisting of a C1-C10 branched or unbranched alkyl or aralkyl, which may be substituted by -OH; -Y- is a direct bond to -E-, or -Y- is -E-R2- where R2 is a C1-C10 branched or unbranched alkyl; Za is chlorine, bromine or iodine; E is 0, NH or an acyclic divalent sulfur atom; Detb is a chemical moiety capable of being detected, preferably comprising biotin or a metal chelator of the formula: or the 4-hydroxy or acyloxy derivative thereof, where R3 is C1-C4 alkyl or CH2COOM, M is the same or different and selected from the group consisting of hydrogen, a metal or non-metal cation or is C,-C,o alkyl, aryl or aralkyl; and m is an integer from 1 to the total number of modified reactive groups on A3. The detectable molecules are useful in in vitro or in vivo assays or therapy.

  式中的可检测分子 其中 A3 是 A2 或聚合物，A3 具有至少一个可修饰的反应基团，该反应基团选自由氨基、羟基、顺 OH、卤化物、芳基、咪唑基、羰基、羧基、硫醇或包含活性碳的残基组成的组；-X- 选自由以下组 C1-C10支链或未支链烷基或芳烷基，可被-OH 取代；-Y- 是与-E- 的直接键，或-Y- 是-E-R2-，其中 R2 是 C1-C10 支链或未支链烷基；Za 是氯、溴或碘；E 是 0、NH 或无环二价硫原子；Detb 是可检测的化学分子，最好包括生物素或式中的金属螯合剂： 或其 4-羟基或酰氧基衍生物，其中 R3 为 C1-C4 烷基或 CH2COOM，M 相同或不同，且选自由氢、金属或非金属阳离子或 C,-C,o烷基、芳基或芳烷基组成的组；m 为 1 至 A3 上修饰反应基团总数的整数。可检测分子可用于体外或体内检测或治疗。
• A drug delivery conjugate
  申请人：ENZO BIOCHEM, INC.

  公开号：EP0285950A2

  公开（公告）日：1988-10-12

  Nucleotides and polynucleotides, including DNA, are chemically modified or labeled so as to be capable of ready detection when attached to and/or incorporated in nucleic acid material.

  核苷酸和多核苷酸（包括 DNA）经过化学修饰或标记，当附着在核酸材料上和/或掺入核酸材料中时，可随时进行检测。
• Protein with a moiety capable of chelating ions attached thereto
  申请人：ENZO BIOCHEM, INC.

  公开号：EP0618228A1

  公开（公告）日：1994-10-05

  Disclosed is a protein to which a moiety capable of chelating an ion is directly or indirectly attached, said attachment being characterized in not interfering substantially with the ability of the moiety to chelate ions.

  本发明公开了一种蛋白质，其上直接或间接附着有能够螯合离子的分子，所述附着物的特点是不会严重干扰分子螯合离子的能力。
• US4707440A
  申请人：——

  公开号：US4707440A

  公开（公告）日：1987-11-17