2,6-Bis(methylsulfonyl)naphthalene

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2,6-Bis(methylsulfonyl)naphthalene
• 化学式: C₁₂H₁₂O₄S₂
• 分子量: 284.4
• InChiKey: NOQVIHAPKMDGTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  85
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• IAP BIR DOMAIN BINDING COMPOUNDS
  申请人：Laurent Alain

  公开号：US20100203012A1

  公开（公告）日：2010-08-12

  Disclosed herein is a compound of Formula 1: or a salt thereof, in which R 1 , R 1a , R 100 , R 100a , R 2 , R 200 , R 3 , R 300 , A, A 1 , Q, Q 1 and BG are as defined herein. Also disclosed is the use of the compounds of Formula 1 to treat disorders of dysregulated apoptosis, such as cancer and cellular proliferative disorders.
• BRIDGED SECONDARY AMINES AND USE THEREOF AS IAP BIR DOMAIN BINDING COMPOUNDS
  申请人：Laurent Alain

  公开号：US20110171171A1

  公开（公告）日：2011-07-14

  A compound of Formula 1.1A: 1.1A or salt thereof, as well as methods of making compounds of Formula 1.1A, methods of using compounds of Formula 1.1A to treat proliferative disorders such as cancer, and related compounds, composition, and methods.