methyl 5-[(4,4,5,7-tetramethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-2-furoate | 578713-55-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: methyl 5-[(4,4,5,7-tetramethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-2-furoate
• 英文别名: methyl 5-[(4,4,5,7-tetramethyl-2,3-dihydrochromen-6-yl)methyl]furan-2-carboxylate
• CAS: 578713-55-0
• 化学式: C₂₀H₂₄O₄
• 分子量: 328.408
• InChiKey: IXYMHDITRPPQPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  48.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 5-[(4,4,5,7-tetramethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-2-furoate 以 甲醇 、 水 为溶剂， 以67.5%的产率得到5-[(4,4,5,7-tetramethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-2-furoic acid
  参考文献：
  名称：

  Non-peptide compounds affecting the action of gonadotropin-releasing hormone (GnRH)

  摘要：

  公开号：

  EP1334972B1
• 作为产物：
  描述：

  methyl 5-{2,6-dimethyl-4-[(3-methylbut-3-enyl)oxy]benzyl}-2-furoate 、 methyl 5-{2,4-dimethyl-6-[(4-methylpent-4-enyl)oxy]benzyl}-2-furoate 在 AlCl₃ 作用下， 以 二氯甲烷 为溶剂， 以23%的产率得到methyl 5-[(4,4,5,7-tetramethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-2-furoate
  参考文献：
  名称：

  Non-peptide compounds affecting the action of gonadotropin-releasing hormone (GnRH)

  摘要：

  公开号：

  EP1334972B1

文献信息

• Non-peptide GnRH agents, pharmaceutical compositions, and methods for their use
  申请人：Pfizer Inc.

  公开号：US20040053951A1

  公开（公告）日：2004-03-18

  Non-peptide GnRH agents that inhibit the effect of gonadotropin-releasing hormone are described. Such agents are useful for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated.

  本文描述了抑制促性腺激素释放激素作用的非肽类GnRH（促性腺激素释放激素）药物。这些药物可用于治疗哺乳动物的生殖障碍和类固醇激素依赖性肿瘤，以及调节生育能力，其中需要抑制促性腺激素释放。
• Non-peptide GnRH agents, Pharmaceutical compositions, and methods for their use
  申请人：Pfizer, Inc.

  公开号：US06833372B2

  公开（公告）日：2004-12-21

  Non-peptide GnRH agents that inhibit the effect of gonadotropin-releasing hormone are described. Such agents are useful for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated.

  本文描述了抑制促性腺激素释放激素作用的非肽类GnRH药物。这些药物可用于治疗哺乳动物生殖障碍和类固醇激素依赖性肿瘤，以及调节生育能力，其中需要抑制促性腺激素释放。
• US6833372B2
  申请人：——

  公开号：US6833372B2

  公开（公告）日：2004-12-21
• [EN] NON-PEPTIDE COMPOUNDS AFFECTING THE ACTION OF GONADOTROPIN-RELEASING HORMONE (GNRH)<br/>[FR] COMPOSES NON-PEPTIDIQUES INFLUANT SUR L'ACTION DE LA GNRH
  申请人：PFIZER

  公开号：WO2003068769A1

  公开（公告）日：2003-08-21

  Non-peptide GnRH agents that inhibit the effect of gonadotropin-releasing hormone are described. Such agents are useful for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. The compound have the following structure: (Formula I)
• Non-peptide compounds affecting the action of gonadotropin-releasing hormone (GnRH)
  申请人：PFIZER INC.

  公开号：EP1334972B1

  公开（公告）日：2006-04-19