4-(Dipropylamino)-1,3,4,5-tetrahydrobenz(cd)indole-6-carboxamide hippurate,L- | 137641-36-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-(Dipropylamino)-1,3,4,5-tetrahydrobenz(cd)indole-6-carboxamide hippurate,L-
• 英文别名: 2-benzamidoacetic acid;(4R)-4-(dipropylamino)-1,3,4,5-tetrahydrobenzo[cd]indole-6-carboxamide
• CAS: 137641-36-2
• 化学式: C27H34N4O4
• 分子量: 478.6
• InChiKey: WNHCMVMMLWRHHG-ZOWNYOTGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.36
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  129
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Crystalline salt of 4-(di-n-propyl)amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz[cd]indole
  申请人：ELI LILLY AND COMPANY

  公开号：EP0444852A2

  公开（公告）日：1991-09-04

  4-(Di-n-propyl)amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz[cd]indole hippurate and its method of preparation and use are provided.

  本发明提供了 4-(二正丙基)氨基-6-氨基甲酰基-1,3,4,5-四氢苯并[cd]吲哚海波酸盐及其制备方法和用途。
• US5397799A
  申请人：——

  公开号：US5397799A

  公开（公告）日：1995-03-14
• [EN] CHEMICAL COMPOUNDS<br/>[FR] COMPOSÉS CHIMIQUES
  申请人：VERNALIS RES LTD

  公开号：WO2002074288A2

  公开（公告）日：2002-09-26

  The use of an effective amount of compound (I) in the manufacture of a medicament for treatment of sexual dysfunction in a patient who is undergoing or is about to undergo treatment with a selective serotonin re-uptake inhibitor; and the use of an effective amount of compound (I) and one or more selective serotonin re-uptake inhibitor(s) in the manufacture of a medicament for the treatment of depression without inducing sexual dysfunction.