N-pentyl-3-(3-hydroxyphenyl)piperidine hydrochloride | 79412-79-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-pentyl-3-(3-hydroxyphenyl)piperidine hydrochloride
• 英文别名: 3-(1-pentylpiperidin-3-yl)phenol;hydrochloride
• CAS: 79412-79-6
• 化学式: C₁₆H₂₅NO*ClH
• 分子量: 283.842
• InChiKey: BABGLWPMISPDRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.18
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  23.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-pentyl-3-(3-methoxyphenyl)piperidine 、 二氧化碳 、 三溴化硼 、 disodium;carbonate 、 盐酸 在 二氯甲烷 、 Sodium sulfate-III 、 乙醇乙醚 作用下， 以 二氯甲烷 为溶剂， 反应 17.0h， 以the desired product (0.40 g, 29%) was obtained的产率得到N-pentyl-3-(3-hydroxyphenyl)piperidine hydrochloride
  参考文献：
  名称：

  Phenyl-azacycloalkanes and use thereof in treatment of central nervous

  摘要：

  该化合物的化学式为##STR1##其中n为1或2，Y为OH，R.sup.1 COO--，R.sup.2 R.sup.3 NCOO--或R.sup.4 O，其中R.sup.1是烷基或可能取代的苯基，R.sup.2是烷基，苯乙基，苄基或苯基基团，R.sup.3为H或烷基，R.sup.4为烯丙基或苄基，R为烷基，羟基烷基，二甲氨基烷基或甲硫基烷基或烯丙基，其制备过程和使用这些化合物的治疗方法。这些化合物对于治疗中枢神经系统的疾病等治疗目的非常有用。

  公开号：

  US04719219A1

文献信息

• Phenyl-azacykloalkanes
  申请人：Carlsson; Per Arvid Emil

  公开号：US04937346A1

  公开（公告）日：1990-06-26

  Compound of the formula ##STR1## wherein n is 1 or 2, Y is OH, R.sup.1 COO--, R.sup.2 R.sup.3 NCOO-- or R.sup.4 O whereby R.sup.1 is an alkyl group, or a possibly substituted phenyl group, R.sup.2 is an alkyl, phenethyl, or benzyl or phenyl group, R.sup.3 is H or an alkyl group and R.sup.4 is an allyl or benzyl group, and R is an alkyl, hydroxyalkyl, dimethylaminoalkyl or methylthioalkyl group or alkenyl group, processes for their preparations and methods of treatment employing such compounds. The compounds are useful for therapeutic purposes, especially for treatment of disorders in the central nervous system.

  化学式为##STR1##的化合物，其中n为1或2，Y为OH，R.sup.1 COO--，R.sup.2 R.sup.3 NCOO--或R.sup.4 O，其中R.sup.1为烷基或可能被取代的苯基，R.sup.2为烷基、苯乙基、苄基或苯基，R.sup.3为H或烷基，R.sup.4为烯丙基或苄基，而R为烷基、羟基烷基、二甲氨基烷基或甲硫基烷基或烯烃基。制备这些化合物的方法和使用这些化合物进行治疗的方法。这些化合物对于治疗中枢神经系统的疾病特别有用。
• Substituted phenyl piperidines
  申请人：Astra Lakemedel Aktiebolag

  公开号：US04426386A1

  公开（公告）日：1984-01-17

  Compounds of the formula ##STR1## wherein n is 1 or 2, Y is OH, R.sup.1 COO--, R.sup.2 R.sup.3 NCOO-- or R.sup.4 O whereby R.sup.1 is an alkyl group, or a possibly substituted phenyl group, R.sup.2 is an alkyl, phenethyl, benzyl or phenyl group, R.sup.3 is H or an alkyl group and R.sup.4 is an allyl or benzyl group, and R is an alkyl, hydroxyalkyl, dimethylaminoalkyl or methylthioalkyl group or alkenyl group, processes for their preparation and pharmaceutical preparations and methods of treatment employing such compounds. The compounds are useful for therapeutic purposes, especially for treatment of disorders in the central nervous system.

  化合物的公式为##STR1##其中n为1或2，Y为OH，R.sup.1COO--，R.sup.2R.sup.3NCOO--或R.sup.4O，其中R.sup.1是烷基或可能被取代的苯基，R.sup.2是烷基，苯乙基，苄基或苯基，R.sup.3为H或烷基，R.sup.4为烯丙基或苄基，而R为烷基，羟基烷基，二甲基氨基烷基或甲硫基烷基或烯基，其制备过程以及使用这些化合物的制药制剂和治疗方法。这些化合物对治疗目的特别有用，尤其是用于治疗中枢神经系统疾病。
• Phenyl-azacycloalkanes and use thereof in treatment of central nervous
  申请人：Carlsson; Per A. E.

  公开号：US04719219A1

  公开（公告）日：1988-01-12

  Compound of the formula ##STR1## wherein n is 1 or 2, Y is OH, R.sup.1 COO--, R.sup.2 R.sup.3 NCOO-- or R.sup.4 O whereby R.sup.1 is an alkyl group, or a possibly substituted phenyl group, R.sup.2 is an alkyl, phenethyl, or benzyl or phenyl group, R.sup.3 is H or an alkyl group and R.sup.4 is an allyl or benzyl group, and R is an alkyl, hydroxyalkyl, dimethylaminoalkyl or methylthioalkyl group or alkenyl group, processes for their preparations and methods of treatment employing such compounds. The compounds are useful for therapeutic purposes, especially for treatment of disorders in the central nervous system.

  该化合物的化学式为##STR1##其中n为1或2，Y为OH，R.sup.1 COO--，R.sup.2 R.sup.3 NCOO--或R.sup.4 O，其中R.sup.1是烷基或可能取代的苯基，R.sup.2是烷基，苯乙基，苄基或苯基基团，R.sup.3为H或烷基，R.sup.4为烯丙基或苄基，R为烷基，羟基烷基，二甲氨基烷基或甲硫基烷基或烯丙基，其制备过程和使用这些化合物的治疗方法。这些化合物对于治疗中枢神经系统的疾病等治疗目的非常有用。
• New phenyl-azacycloalkanes, processes for preparation and pharmaceutical preparations for such compounds
  申请人：Astra Läkemedel Aktiebolag

  公开号：EP0030526A1

  公开（公告）日：1981-06-17

  Compounds of the formula wherein n is 1 or 2, Y is OH, R'COO-, R2R3NCOO- or R4O whereby R1 is an alkyl group, or a possibly substituted phenyl group, R2 is an alkyl, phenethyl, benzyl or phenyl group, R3 is H or an alkyl group and R4 is an allyl or benzyl group, and R is an alkyl, hydroxyalkyl, dimethylaminoalkyl or methylthioalkyl group or alkenyl group, processes for their preparation and pharmaceutical preparations and methods of treatment employing such compounds. The compounds are useful for therapeutic purposes, especially for treatment of disorders in the central nervous system.

  式中化合物 其中 n 是 1 或 2，Y 是 OH、R'COO-、R2R3NCOO- 或 R4O 其中 R1 是烷基或可能取代的苯基，R2 是烷基、苯乙基、苄基或苯基，R3 是 H 或烷基，R4 是烯丙基或苄基，R 是烷基、羟基烷基、二甲基氨基烷基或甲硫基烷基或烯基，其制备工艺和药物制剂以及使用此类化合物的治疗方法。这些化合物可用于治疗目的，特别是治疗中枢神经系统疾病。
• New compounds useful as intermediates or starting materials for preparation of therapeutically useful phenyl-azacycloalkanes
  申请人：Carlsson, Per Arvid Emil

  公开号：EP0084920A2

  公开（公告）日：1983-08-03

  Compounds of the formula wherein Z3 is R or R6CO, wherein R is an alkyl group having 1-5 carbon atoms, a hydroxyalkyl, dimethylaminoalkyl or methylthioalkyl group having 2-6 carbon atoms in the alkyl part and having the heteroatom bound in a position other than 1-position, an alkenyl group having 3-5 carbon atoms other than an 1- alkenyl group, and R6 is an alkyl or alkoxy group containing 1-4 carbon atoms or an alkenyl group with 2-4 carbon atoms, R is an alkyl group with 1-5 carbon atoms, an allyl or benzyl group, and n is 1 or 2 provided that Z3 is other than methyl and ethyl when n is 2 and R7 is CH3 or an acid addition salt thereof. The compounds are useful as intermediates or starting materials for preparation of therapeutically useful substituted phenyl-azacycloalkanes.

  式中的化合物 其中 Z3 是 R 或 R6CO，其中 R 是含有 1-5 个碳原子的烷基、烷基部分含有 2-6 个碳原子且杂原子结合在 1 位以外位置的羟基烷基、二甲基氨基烷基或甲基硫代烷基、含有 3-5 个碳原子的烯基（1-烯基除外）、R6 是含有 1-4 个碳原子的烷基或烷氧基，或含有 2-4 个碳原子的烯基，R 是含有 1-5 个碳原子的烷基、烯丙基或苄基，n 是 1 或 2，条件是当 n 为 2 时，Z3 不是甲基和乙基，R7 是 CH3 或其酸加成盐。这些化合物可作为中间体或起始原料，用于制备对治疗有用的取代苯基氮杂环烷烃。