N-[[(5S)-3-[3-fluoro-4-[4-(2-hydroxyacetyl)piperazin-1-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-[[(5S)-3-[3-fluoro-4-[4-(2-hydroxyacetyl)piperazin-1-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
• 英文别名: N-[[3-[3-fluoro-4-[4-(2-hydroxyacetyl)piperazin-1-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
• 化学式: C₁₈H₂₃FN₄O₅
• 分子量: 394.4
• InChiKey: SIMWTRCFFSTNMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Treatment of urinary tract infections with antibacterial oxazolidinones
  申请人：——

  公开号：US20010046992A1

  公开（公告）日：2001-11-29

  The present invention is a method of treating a warm blooded mammal who has a urinary tract infection caused by a Gram-positive organism who is in need of such treatment, which comprises administering to the mammal in need of such treatment a urinary therapeutically effective amount of an antibacterial oxazolidinone.

  本发明涉及一种治疗需要此类治疗的温血哺乳动物的方法，该动物患有由革兰氏阳性微生物引起的尿路感染，包括向需要此类治疗的哺乳动物施用尿路治疗有效量的抗菌氧唑烷。
• TOPICAL ADMINISTRATION OF OXAZOLIDINONES FOR TRANSDERMAL DELIVERY
  申请人：——

  公开号：US20020009483A1

  公开（公告）日：2002-01-24

  Disclosed is a method of treating a non-topical infection selected from the group consisting of ear infections, skin and soft tissue infections, acne, infected wounds, bacteremia, in a useful warm blooded mammal who is in need of such treatment which comprises topical administration of a pharmaceutical formulation containing a transdermally effective amount of an OXAZOLIDINONE.

  揭示了一种治疗非局部感染的方法，所述非局部感染包括耳部感染、皮肤和软组织感染、痤疮、感染的伤口、菌血症，适用于需要此类治疗的温血哺乳动物，包括局部给药含有足够透皮作用量的氧唑烷类药物制剂。
• Oxazolidinone photoaffinity probes
  申请人：——

  公开号：US20030073696A1

  公开（公告）日：2003-04-17

  Disclosed are novel compounds that are useful and effective as photoaffinity probes and methods of using oxazolidinone photoaffinity probes.

  披露了一种新颖的化合物，这些化合物可作为光亲和探针，并且揭示了使用噁唑烷酮光亲和探针的方法。
• Treating infections by administration of oxazolidinones
  申请人：——

  公开号：US20030096850A1

  公开（公告）日：2003-05-22

  Disclosed is a method of treating ear infections, soft-tissue infections, acne, or cellulitis in a mammal in need thereof comprising administration of Oxazolidinone in a pharmaceutical formulation or composition to the skin of the mammal at a site proximal to the site of the infection to deliver a pharmaceutically-effective amount of Oxazolidinone to the infection to have a concentration of the Oxazolidinone at the site of infection of about 0.5 to about 4 &mgr; g/ml, provided that the application for administration is not directly to the site of the infection.

  揭示了一种治疗哺乳动物中的耳部感染、软组织感染、痤疮或红斑病的方法，包括向哺乳动物的皮肤施用含有氧唑烷酮的药物制剂或组合物，位于感染部位附近的位置，以向感染部位提供药效有效量的氧唑烷酮，使感染部位的氧唑烷酮浓度约为0.5至4微克/毫升，前提是施用的应用不直接作用于感染部位。
• Container for linezolid intravenous solution
  申请人：——

  公开号：US20010049383A1

  公开（公告）日：2001-12-06

  The present invention is a container for an IV aqueous solution of a Gram-positive oxazolidinone agent, such as linezolid a the compound of formula: 1 which comprises having the container-solution contact surface material be a polyolefin.

  本发明是一种用于含有革兰氏阳性氧唑烷酮类药剂（如利奈唑胺）的静脉注射水溶液的容器，该药剂的化合物式为：1，其特征在于容器-溶液接触表面材料为聚烯烃。