Azanium;2-[4-(2-methylpropyl)phenyl]propanoate | 126716-17-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: Azanium;2-[4-(2-methylpropyl)phenyl]propanoate
• CAS: 126716-17-4
• 化学式: C13H21NO2
• 分子量: 223.31
• InChiKey: DRLXZRDDGHMYLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.11
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  41.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Ibuprofen amine salts and synthesis thereof
  申请人：Lee Tu

  公开号：US20100022798A1

  公开（公告）日：2010-01-28

  The present invention discloses an ibuprofen amine salt and the synthesis thereof, and more particularly an ibuprofen amine salt yielded by the neutralization reaction of a racemic mixture of ibuprofen with tris(hydroxymethyl)aminomethane in a solution system of water and an organic solvent. Compared with racemic mixtures of ibuprofen, the ibuprofen amine salt has higher solubility and a higher melting point, thereby having better bioavailability and properties than racemic mixtures of ibuprofen during pharmaceutical processing. Further, the ibuprofen amine salts of the present invention are stable between pH 4 and 9 so that they can be more widely applied to medicines.

  本发明揭示了一种布洛芬胺盐及其合成方法，更具体地说，是通过在水和有机溶剂溶液体系中，将布洛芬的外消旋混合物与三羟甲基氨甲烷中和反应所得到的一种布洛芬胺盐。与布洛芬的外消旋混合物相比，布洛芬胺盐具有更高的溶解度和更高的熔点，在制药过程中具有更好的生物利用度和性能。此外，本发明的布洛芬胺盐在pH 4至9之间稳定，因此可以更广泛地应用于药品中。
• STABLE PHARMACEUTICAL COMPOSITION CONTAINING NON-STEROIDAL ANTI-INFLAMMATORY DRUG DERIVATIVE
  申请人：Zhejiang Yuejia Pharmaceuticals Co., Ltd

  公开号：EP3701937A1

  公开（公告）日：2020-09-02

  A stable pharmaceutical composition containing a non-steroidal anti-inflammatory drug derivative, at least comprising a separated solid part and liquid part, the solid part comprising a therapeutically effective dose of non-steroidal anti-inflammatory drug derivative and the liquid part being a pharmaceutically acceptable solvent.

  一种含有非甾体抗炎药物衍生物的稳定药物组合物，至少包括分离的固体部分和液体部分，固体部分含有治疗有效剂量的非甾体抗炎药物衍生物，液体部分为药学上可接受的溶剂。
• PULVERKLARLACKDISPERSIONEN (PULVERSLURRY-KLARLACKE), VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG
  申请人：BASF Coatings AG

  公开号：EP1287083B1

  公开（公告）日：2004-09-22
• COMPOSITIONS CONTAINING SOLID IBUPROFEN CONCENTRATES AND METHODS OF MAKING SOLID IBUPROFEN CONCENTRATES
  申请人：Pharmaceutics International, Inc.

  公开号：EP1978942A1

  公开（公告）日：2008-10-15
• Compositions containing solid ibuprofen concentrates and methods of making solid ibuprofen concentrates
  申请人：Hassan Emadeldin

  公开号：US20070184100A1

  公开（公告）日：2007-08-09

  The invention provides a composition comprising a solid ibuprofen concentrate, wherein the solid ibuprofen concentrate comprises (a) a solid ibuprofen free acid and (b) a solid ibuprofen alkali salt, and wherein at least 90% of the weight of the solid ibuprofen concentrate is ibuprofen free acid and ibuprofen alkali salt, as well as methods of producing such a composition.