(S)-(naphthalen-1-yl)(pyridin-2-yl)methanol | 1375005-47-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (S)-(naphthalen-1-yl)(pyridin-2-yl)methanol
• 英文别名: (S)-(1-naphthyl)(pyridin-2-yl)methanol；(S)-naphthalen-1-yl(pyridin-2-yl)methanol
• CAS: 1375005-47-2
• 化学式: C₁₆H₁₃NO
• 分子量: 235.285
• InChiKey: WBNAKYUCYCWBFR-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 盐酸 作用下， 以 乙酸乙酯 为溶剂， 反应 1.0h， 以90 mg的产率得到(S)-(naphthalen-1-yl)(pyridin-2-yl)methanol
  参考文献：
  名称：

  JP6858993

  摘要：

  公开号：

文献信息

• Amino alcohol-boron-binol complex and method for preparing optically active amino alcohol derivative by using same
  申请人：MOLECULES & MATERIALS CO., LTD.

  公开号：US11130734B2

  公开（公告）日：2021-09-28

  Disclosed are an amino alcohol-boron-binol complex as an intermediate, including Complex 3-1-1 shown below, and a method for preparing an optically active amino alcohol by using the same, wherein a racemic amino alcohol is resolved in an enationselective manner using a boron compound and a (R)- or (S)-binol, whereby an amino alcohol derivative with high optical purity can be prepared at high yield.

  本发明公开了一种作为中间体的氨基醇-硼-比醇络合物（包括下图所示的络合物 3-1-1），以及使用该络合物制备光学活性氨基醇的方法，其中使用硼化合物和(R)-或(S)-比醇以烯化选择性方式解析外消旋氨基醇，从而可以高产率制备出光学纯度高的氨基醇衍生物。
• Pyridylmagnesiates: generation by bromine–metal exchange and enantioselective addition to aldehydes
  作者：Delphine Catel、Olivier Payen、Floris Chevallier、Florence Mongin、Philippe C. Gros

  DOI：10.1016/j.tet.2012.03.058

  日期：2012.5

  Butyl and dibutylmagnesiates incorporating chiral ligands have been prepared and their reactivity studied. The reagents were efficient to promote the clean bromine-magnesium exchange of azinyl bromides at room temperature and subsequent reaction with aldehydes affording pyridylcarbinols. (R,R)-TADDOL-based dibutylmagnesiate was the best reagent leading to acceptable to good enantioselectivities, depending on the substrate and on the aldehyde substitution. This is the first example of enantioselective addition of in situ generated pyridylmagnesiate to carbonyl electrophiles. (C) 2012 Elsevier Ltd. All rights reserved.
• AMINO ALCOHOL-BORON-BINOL COMPLEX AND METHOD FOR PREPARING OPTICALLY ACTIVE AMINO ALCOHOL DERIVATIVE BY USING SAME
  申请人：MOLECULES & MATERIALS CO., LTD.

  公开号：US20210206719A1

  公开（公告）日：2021-07-08

  Disclosed are an amino alcohol-boron-binol complex as an intermediate, including Complex 3-1-1 shown below, and a method for preparing an optically active amino alcohol by using the same, wherein a racemic amino alcohol is resolved in an enation selective manner using a boron compound and a (R)- or (S)-binol, whereby an amino alcohol derivative with high optical purity can be prepared at high yield.