beta-亚乙基-6-甲氧基-alpha,alpha-二甲基萘-2-丙酸 | 60533-05-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: beta-亚乙基-6-甲氧基-alpha,alpha-二甲基萘-2-丙酸
• 英文名称: 3-(6-methoxy-[2]naphthyl)-2,2-dimethyl-pent-3-enoic acid
• 英文别名: 3-(6-Methoxy-[2]naphthyl)-2,2-dimethyl-pent-3-ensaeure；β-ethylidene-6-methoxy-α,α-dimethylnaphthalene-2-propionic acid；beta-Ethylidene-6-methoxy-alpha,alpha-dimethylnaphthalene-2-propionic acid；3-(6-methoxynaphthalen-2-yl)-2,2-dimethylpent-3-enoic acid
• CAS: 60533-05-3
• 化学式: C₁₈H₂₀O₃
• 分子量: 284.355
• InChiKey: ARMLYYXIJXARED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2918990090

反应信息

• 作为反应物：
  描述：

  beta-亚乙基-6-甲氧基-alpha,alpha-二甲基萘-2-丙酸 在 lead(IV) acetate 作用下， 生成 3-(6-methoxy-[2]naphthyl)-4-methyl-pent-3-en-2-ol
  参考文献：
  名称：

  Jacques et al., Bulletin de la Societe Chimique de France, 1959, p. 424,427

  摘要：

  DOI：
• 作为产物：
  描述：

  3-(6-methoxy-[2]naphthyl)-2,2-dimethyl-pent-3-enoic acid ethyl ester 在 sodium hydroxide 、 1-methoxyethanol 作用下， 生成 beta-亚乙基-6-甲氧基-alpha,alpha-二甲基萘-2-丙酸
  参考文献：
  名称：

  spo12 is a multicopy suppressor of mcs3 that is periodically expressed in fission yeast mitosis

  摘要：

  Hyperactivation of Cdc2 in fission yeast causes cells to undergo a lethal premature mitosis, a phenomenon called mitotic catastrophe. This phenotype is observed in cdc2-3w wee1-50 cells at high temperature and is suppressed by a single recessive mutant, mcs3-12. Mcs3 acts independently of the Wee1 kinase and Cdc25 phosphatase, two major regulators of Cdc2. We have isolated multicopy suppressors of the cell cycle arrest phenotype of mcs3-12 wee1-50 cdc25-22 cells, but did not identify the mcs3 gene itself. Instead several known mitotic regulators were isolated, including the Cdc25 phosphatase, Wis2 cyclophilin, Cek1 kinase. and an Hsp90 homologue, Swo1. We also isolated clones encoding non-functional, truncated forms of the Wee1 kinase and Dis2 type 1 phosphatase. In addition we identified a multicopy suppressor that encodes a structural homologue of the budding yeast SPO12 gene. We find that overexpression of fission yeast spo12 not only suppresses the phenotype of the mcs3-12 wee1-50 cdc25-22 strain, but also that of a win1-1 wee1-50 cdc25-22 strain at high temperature, indicating that the function of spo12 is not directly related to mcs3. We show that spo12 mRNA is periodically expressed during the fission yeast cell cycle, peaking at the G2/M transition coincidently with cdc15. Deletion of spo12, however, has no overt effect on either the mitotic or meiotic cell cycles, except when the function of the major B type cyclin, Cdc13, is compromised.

  DOI：

  10.1007/s004380000324

文献信息

• Malzieu, Bulletin de la Societe Chimique de France, 1976, vol. II, # 5-6, p. 879 - 882
  作者：Malzieu

  DOI：——

  日期：——
• Horeau; Jacques, Bulletin de la Societe Chimique de France, 1956, p. 1467,1470
  作者：Horeau、Jacques

  DOI：——

  日期：——
• Tard et al., Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1958, vol. 246, p. 3644
  作者：Tard et al.

  DOI：——

  日期：——
• Jacques et al., Bulletin de la Societe Chimique de France, 1959, p. 424,427
  作者：Jacques et al.

  DOI：——

  日期：——
• spo12 is a multicopy suppressor of mcs3 that is periodically expressed in fission yeast mitosis
  作者：J. M. Samuel、N. Fournier、V. Simanis、J. B. A. Millar

  DOI：10.1007/s004380000324

  日期：2000.10

  Hyperactivation of Cdc2 in fission yeast causes cells to undergo a lethal premature mitosis, a phenomenon called mitotic catastrophe. This phenotype is observed in cdc2-3w wee1-50 cells at high temperature and is suppressed by a single recessive mutant, mcs3-12. Mcs3 acts independently of the Wee1 kinase and Cdc25 phosphatase, two major regulators of Cdc2. We have isolated multicopy suppressors of the cell cycle arrest phenotype of mcs3-12 wee1-50 cdc25-22 cells, but did not identify the mcs3 gene itself. Instead several known mitotic regulators were isolated, including the Cdc25 phosphatase, Wis2 cyclophilin, Cek1 kinase. and an Hsp90 homologue, Swo1. We also isolated clones encoding non-functional, truncated forms of the Wee1 kinase and Dis2 type 1 phosphatase. In addition we identified a multicopy suppressor that encodes a structural homologue of the budding yeast SPO12 gene. We find that overexpression of fission yeast spo12 not only suppresses the phenotype of the mcs3-12 wee1-50 cdc25-22 strain, but also that of a win1-1 wee1-50 cdc25-22 strain at high temperature, indicating that the function of spo12 is not directly related to mcs3. We show that spo12 mRNA is periodically expressed during the fission yeast cell cycle, peaking at the G2/M transition coincidently with cdc15. Deletion of spo12, however, has no overt effect on either the mitotic or meiotic cell cycles, except when the function of the major B type cyclin, Cdc13, is compromised.