4-(Nitrooxy)butyl 2-(6-methoxynaphthalen-2-yl)propanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-(Nitrooxy)butyl 2-(6-methoxynaphthalen-2-yl)propanoate
• 英文别名: 4-nitrooxybutyl 2-(6-methoxynaphthalen-2-yl)propanoate
• 化学式: C18H21NO6
• 分子量: 347.4
• InChiKey: AKFJWRDCWYYTIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  90.6
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Method for the preparation of organic nitrates
  申请人：Lonza AG

  公开号：EP2048129A1

  公开（公告）日：2009-04-15

  The present invention relates to a process for the preparation of organic nitrates having at least one nitryloxy and at least one hydroxy group, wherein the at least one hydroxy group may be present in form of an esterified hydroxy residue, the latter being esterified with an acid other than nitric acid.

  本发明涉及一种制备具有至少一个硝基氧基和至少一个羟基的有机硝酸酯的方法，其中至少一个羟基可以以酯化羟基残基的形式存在，后者与除硝酸以外的酸酯化。
• ANHYDRIDE DERIVATIVES OF 2-(S)-(6-METHOXY-2-NAPHTYL)-PROPANOIC ACID, PREPARATION METHOD AND USE THEREOF
  申请人：Yang Hao-Cheng

  公开号：US20120226068A1

  公开（公告）日：2012-09-06

  The present invention provides a novel anhydride derivative of 2-(S)-(6-methoxy-2-naphtyl)-propanoic acid for preparing nitrooxyalkyl esters of 2-(S)-(6-methoxy-2-naphtyl)-propanoic acid with high purity to meet requirements of the industry.

  本发明提供了一种新颖的2-(S)-(6-甲氧基-2-萘基)-丙酸的酐衍生物，用于制备高纯度的2-(S)-(6-甲氧基-2-萘基)-丙酸的硝氧烷基酯，以满足行业需求。
• Ophthalmic compositions containing a nitric oxide donor
  申请人：Nicox Science Ireland

  公开号：EP2826491A1

  公开（公告）日：2015-01-21

  The present invention relates to compositions comprising a 4-nitrooxybutan-1-ol alkyl ester as nitric oxide donor. More specifically, the invention relates to compositions comprising 4-nitrooxybutan - 1-ol alkyl ester as a nitric oxide donor and an ophthalmic drug, useful in controlling elevated intraocular pressure associated with glaucoma or ocular hypertension associated with other diseases or conditions. The invention is also directed to methods of controlling intraocular pressure utilizing said compositions.

  本发明涉及包含4-硝基氧丁醇烷基酯作为一氧化氮供体的组合物。更具体地，本发明涉及包含4-硝基氧丁醇烷基酯作为一氧化氮供体和一种眼科药物的组合物，用于控制与青光眼或其他疾病或状况相关的高眼压。该发明还涉及利用上述组合物控制眼内压的方法。
• [EN] OPHTHALMIC COMPOSITIONS CONTAINING A NITRIC OXIDE DONOR<br/>[FR] COMPOSITIONS OPHTALMIQUES CONTENANT UN DONNEUR D'OXYDE NITRIQUE
  申请人：NICOX SCIENCE IRELAND

  公开号：WO2015007552A1

  公开（公告）日：2015-01-22

  The present invention relates to compositions comprising a 4-nitrooxybutan-1-ol alkyl ester as nitric oxide donor. More specifically, the invention relates to compositions comprising 4-nitrooxybutan-1-ol alkyl ester as a nitric oxide donor and an ophthalmic drug, useful in controlling elevated intraocular pressure associated with glaucoma or ocular hypertension associated with other diseases or conditions. The invention is also directed to methods of controlling intraocular pressure utilizing said compositions.

  本发明涉及含有4-硝基氧丁醇烷基酯作为一氧化氮供体的组合物。更具体地，本发明涉及含有4-硝基氧丁醇烷基酯作为一氧化氮供体和一种眼科药物的组合物，用于控制与青光眼相关的高眼压或其他疾病或状况相关的眼压升高。本发明还涉及利用上述组合物控制眼压的方法。
• [EN] PROCESS FOR PREPARING NITROOXYALKYL SUBSTITUTED ESTERS OF CARBOXYLIC ACIDS, INTERMEDIATES USEFUL IN SAID PROCESS AND PREPARATION THEREOF<br/>[FR] PROCEDE DE PREPARATION D'ESTERS D'ACIDES CARBOXYLIQUES A SUBSTITUTION NITROOXYALKYLE, INTERMEDIAIRES UTILISES DANS LEDIT PROCEDE ET LEUR PREPARATION
  申请人：NICOX SA

  公开号：WO2004020385A1

  公开（公告）日：2004-03-11

  The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of a drug and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independently an integer from 0 to 6, and p is 0 or 1, and X is O, S, SO, SO2, NR13 or PR13 or an aryl, heteroaryl group, said process comprising reacting a compound of formula (B) R-COOZ (B) wherein R is as defined above and Z is hydrogen or a cation selected from: Li+, Na+, K+, Ca++, Mg++, tetralkylammonium, tetralkylphosphonium, with a compound of formula (C), as reported in the description, wherein R1-R12 and m, n, o, p, q, r, s are as defined above and Y is a suitable leaving group.

  本发明涉及一种制备一般式(A)化合物的过程，如描述中所述，其中R是药物的基团，R1-R12是氢或烷基基团，m、n、o、q、r和s分别是0到6之间的整数，p为0或1，X为O、S、SO、SO2、NR13或PR13或芳基、杂环芳基基团，所述过程包括将一种一般式(B)的化合物与一种一般式(C)的化合物反应，其中R为上述定义，Z为氢或从Li+、Na+、K+、Ca++、Mg++、四烷基铵、四烷基磷酸盐中选择的阳离子，R1-R12和m、n、o、p、q、r、s如上所述，Y为适当的离去基团。