Naphthoquinonimine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Naphthoquinonimine
• 英文别名: 2-iminonaphthalene-1,4-dione
• 化学式: C₁₀H₇NO₂
• 分子量: 173.17
• InChiKey: CWBAMDVCIHSKNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  58
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] METHOD FOR INHIBITING TRYPANSOMA CRUZI<br/>[FR] PROCÉDÉ D'INHIBITION DE TRYPANSOMA CRUZI
  申请人：UNIV HOWARD

  公开号：WO2013016661A1

  公开（公告）日：2013-01-31

  In its broadest aspect, a method for treating a mammalian patient at risk or suffering from a disease caused by a kinetoplastid parasite comprises administering to such subject an effective kinetoplasticidal amount of an imido-substituted 1,4- naphthoquinone to inhibit the kinetoplastid. In an important aspect, a method of inhibiting Trypanosoma cruzi comprises administering to a patient for prophylaxis or to a patient in need of treatment an antitrypanosomal effective amount of an imido-substituted 1 A-naphthoquinone.

  在其最广泛的方面，一种治疗受威胁或患有由原生质体寄生虫引起的疾病的哺乳动物患者的方法包括向该受试者施用有效的威力质体杀灭剂量的亚胺取代的1,4-萘醌以抑制威力体。在一个重要方面，一种抑制克氏锥虫的方法包括向需要预防或治疗的患者施用亚胺取代的1 A-萘醌的抗克氏锥虫有效量。
• [EN] METHODS FOR TREATING LEISHMANIASIS<br/>[FR] MÉTHODES DE TRAITEMENT DE LA LEISHMANIOSE
  申请人：UNIV HOWARD

  公开号：WO2013074930A1

  公开（公告）日：2013-05-23

  Methods are provided to inhibit proliferation of Leishmania parasites, and in particular Leishmania donovani with imido-substituted 1,4-naphthoquinones, including novel compounds. Administering an imido-substituted 1,4-naphthoquinone can be used to provide prophylaxis or treatment to a patient in need of treatment against leishmaniasis disease.

  提供了一种方法来抑制利什曼原虫（Leishmania）的增殖，特别是对利什曼东非原虫（Leishmania donovani）使用带有亚胺取代的1,4-萘醌类化合物，包括新颖的化合物。给予亚胺取代的1,4-萘醌类化合物可以用于为需要治疗利什曼病的患者提供预防或治疗。
• METHODS FOR TREATING LEISHMANIASIS
  申请人：HOWARD UNIVERSITY

  公开号：US20140336187A1

  公开（公告）日：2014-11-13

  Methods are provided to inhibit proliferation of Leishmania parasites, and in particular Leshmania donovani with imido-substituted 1,4-naphthoquinones, including novel compounds. Administering an imido-substituted 1,4-naphthoquinone can used to provide prophylaxis or treatment to a patient in need of treatment against leishmaniasis disease.

  提供了抑制利什曼原虫增殖的方法，特别是使用含亚胺基取代的1,4-萘醌类化合物抑制利什曼原虫的增殖，包括新型化合物。给予亚胺基取代的1,4-萘醌类化合物可以用于为需要治疗利什曼病的患者提供预防或治疗。
• Aromatic diazo compounds, production method thereof and photosensitive compositions using the same
  申请人：TOYO GOSEI KOGYO CO., LTD.

  公开号：EP0470581A2

  公开（公告）日：1992-02-12

  57 An aromatic diazo compound having at least two groups of Formula (I) in the molecule. This aromatic diazo compound can be handled under visible light free from ultraviolet, is high in photosensitivity, and can be produced by a simple synthesis method. The diazo compound has a high solubility in organic solvents, appropriate for use as a photosensitive material for a lithographic printing plate, can be easily developed by an alkaline developing solution mainly based on an alkaline aqueous solution, and has a water solubility appropriate for use in a screen printing plate. wherein Z1 indicates (wherein φ1 is arylene or substituted arylene; and -φ2 is lower alkyl, lower alkylene, or aryl or substituted aryl.) R1 and R2 are H, alkyl of C1 to C8, or alkyloxy of C1 to C8; X- is anion; and R3 indicates alkyl, saturated alkyl, aralkyl, substituted aralkyl, or a group similar to

  57 分子中至少含有两个式（I）基团的芳香重氮化合物。这种芳香重氮化合物可在可见光下处理，不受紫外线影响，光敏性高，可通过简单的合成方法制得。该重氮化合物在有机溶剂中的溶解度高，适合用作平版印刷板的感光材料，可以很容易地通过主要基于碱性水溶液的碱性显影液显影，并且具有适合用于丝网印刷板的水溶性。 其中 Z1 表示 (其中 φ1 是芳基或取代芳基；而 -φ2 是 低级烷基、低级亚烷基、芳基或取代芳基）。 R1 和 R2 是 H、C1 至 C8 的烷基或 C1 至 C8 的烷氧基；X- 是阴离子；R3 表示烷基、饱和烷基、芳烷基、取代芳烷基或与之相似的基团。
• Presensitized plate for use in making lithographic printing plate
  申请人：Fuji Photo Film Co., Ltd.

  公开号：EP0530815A1

  公开（公告）日：1993-03-10

  A presensitized plate for use in making a lithographic printing plate comprises a substrate provided thereon with a light-sensitive layer formed from a light-sensitive composition comprising a diazonium polymeric compound having two kinds of specific repeating units and a lipophilic polymeric compound having an acid value of not less than 20 and less than 250. The presensitized plate can provide a lithographic printing plate having excellent printing durability since the diazonium compound used has a high molecular weight. Moreover, since the diazonium compound has alkali-soluble groups and the lipophilic compound having an acid value of not less than 20 and less than 250 and easily soluble in an alkaline water is used as a binder, the presensitized plate has good developability and can provide a lithographic printing plate free of background contamination.

  一种用于制作平版印刷板的预敏板，包括一个基板，基板上有一个感光层，感光层由感光组合物形成，感光组合物包括具有两种特定重复单元的重氮高分子化合物和酸值不小于 20 且小于 250 的亲脂高分子化合物。由于所使用的重氮化合物具有较高的分子量，因此预感光版材可以提供具有出色印刷耐久性的平版印刷版材。此外，由于重氮化合物具有碱溶性基团，而亲脂性化合物的酸值不小于 20 且小于 250，并且易溶于碱水作为粘合剂，因此预敏印版具有良好的显影性，可以提供无背景污染的平版印刷版。