2-(Naphthalen-1-yl)-3,5-diphenyl-2,3-dihydro-1H-tetrazole | 685110-14-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(Naphthalen-1-yl)-3,5-diphenyl-2,3-dihydro-1H-tetrazole
• 英文别名: 2-naphthalen-1-yl-3,5-diphenyl-1H-tetrazole
• CAS: 685110-14-9
• 化学式: C₂₃H₁₈N₄
• 分子量: 350.4
• InChiKey: POVFIALPFNAYPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• METHOD OF MEASUREMENT OF MATERIAL AND TESTPIECE
  申请人：KABUSHIKI KAISHA KYOTO DAIICHI KAGAKU

  公开号：EP0860695A1

  公开（公告）日：1998-08-26

  A method of measuring an analyte, comprising a step of measuring a detectable substance by using a reaction system including a formation reaction of the detectable substance based on a chemical reaction of the analyte contained in a sample, wherein a layered inorganic compound is caused to exist in the reaction system including the formation reaction of the detectable substance, whereby high-sensitivity measurement is made possible, the detectable substance can be stabilized to improve accuracy of the measurement, a rate of a chemical reaction is increased to enable quick measurement, and high-sensitivity measurement is made possible even in a reaction system which forms an insoluble substance. Also, it can be provided an analytical testing piece for measuring an analyte, by measuring a detectable substance by using a reaction system including a formation reaction of the detectable substance based on a chemical reaction of the analyte contained in a sample, wherein the testing piece comprises at least one test portion having a detection portion for detecting the detectable substance and contains a layered inorganic compound at least in the test portion, whereby diffusion and elution of a dyestuff or the like is prevented, more sensitive and accurate simple analysis is made possible, and easy handling is possible.

  一种测量被分析物的方法，包括以下步骤：根据样品中含有的被分析物的化学反应，使用包括可检测物质的形成反应的反应系统测量可检测物质，其中在包括可检测物质的形成反应的反应系统中导致层状无机化合物的存在、从而实现高灵敏度测量，稳定可检测物质以提高测量精度，提高化学反应速率以实现快速测量，即使在形成不溶性物质的反应体系中也能实现高灵敏度测量。此外，还可以提供一种用于测量被分析物的分析检测件，通过使用反应系统测量可检测物质，该反应系统包括基于样品中所含被分析物的化学反应的可检测物质的形成反应，其中检测件包括至少一个测试部分，该测试部分具有用于检测可检测物质的检测部分，并且至少在测试部分中包含分层无机化合物，从而防止染料或类似物的扩散和洗脱，实现更灵敏、更准确的简单分析，并且易于处理。
• Test strip for creatine kinase activity measurement
  申请人：UNITIKA LTD.

  公开号：EP0924302A2

  公开（公告）日：1999-06-23

  Test strips by which creatine kinase activity can be quantitatively measured at a high sensitivity within a broad measuring range and which have excellent storage stability. Particularly, test strips for the measurement of creatine kinase activity, which comprises a carrier, a dehydrogenase, a diaphorase, NAD or NADP, and a water-soluble tetrazolium compound.

  可在较宽的测量范围内以较高的灵敏度定量测定肌酸激酶活性，并具有良好储存稳定性的试纸。特别是用于测量肌酸激酶活性的试纸，它由载体、脱氢酶、二磷酸酶、NAD 或 NADP 和水溶性四唑化合物组成。
• SPECIMEN HAVING CAPABILITY OF SEPARATING SOLID COMPONENT
  申请人：ARKRAY, Inc.

  公开号：EP1271143A1

  公开（公告）日：2003-01-02

  A test strip having the capability of separating blood cells from whole blood, wherein it has a porous reagent layer comprising beads, an inorganic gel and a reagent that causes a detectable reaction with a substance to be detected, and a substrate that supports the reagent layer, wherein the beads are adhered to each other with the inorganic gel, and interstices are formed between the beads to trap a solid. The test strip can thus be used for separating blood cells from a whole blood including blood cells and plasma and detecting a substance to be detected, such as glucose, contained in plasma. The use of the test strip allows the measurement of a substance to be detected even by measurement of a transmitted light, the exhibition of good oxygen permeability, and thus can be used for measuring a substance to be detected with improved accuracy.

  一种能从全血中分离血细胞的试纸，它具有一个多孔试剂层，该试剂层由微珠、无机凝胶和能与待检测物质发生可检测反应的试剂组成，以及一个支撑试剂层的基板，其中微珠与无机凝胶相互粘附，微珠之间形成间隙以吸附固体。因此，该试纸可用于从包括血细胞和血浆在内的全血中分离出血细胞，并检测血浆中的待检测物质，如葡萄糖。使用该试纸甚至可以通过透射光的测量来检测某种物质，显示出良好的透氧性，从而可以更准确地测量某种待检测物质。
• Specimen having capability of separating solid component
  申请人：——

  公开号：US20030044316A1

  公开（公告）日：2003-03-06

  A test strip having the capability of separating blood cells from whole blood, wherein it has a porous reagent layer comprising beads, an inorganic gel and a reagent that causes a detectable reaction with a substance to be detected, and a substrate that supports the reagent layer, wherein the beads are adhered to each other with the inorganic gel, and interstices are formed between the beads to trap a solid. The test strip can thus be used for separating blood cells from a whole blood including blood cells and plasma and detecting a substance to be detected, such as glucose, contained in plasma. The use of the test strip allows the measurement of a substance to be detected even by measurement of a transmitted light, the exhibition of good oxygen permeability, and thus can be used for measuring a substance to be detected with improved accuracy.

  一种能从全血中分离血细胞的试纸，它具有一个多孔试剂层，该试剂层由微珠、无机凝胶和能与待检测物质发生可检测反应的试剂组成，以及一个支撑试剂层的基板，其中微珠与无机凝胶相互粘附，微珠之间形成间隙以吸附固体。因此，该试纸可用于从包括血细胞和血浆在内的全血中分离出血细胞，并检测血浆中的待检测物质，如葡萄糖。使用该试纸甚至可以通过透射光的测量来检测某种物质，显示出良好的透氧性，从而可以更准确地测量某种待检测物质。
• Method for measuring substance and testing piece
  申请人：——

  公开号：US20030175984A1

  公开（公告）日：2003-09-18

  A method of measuring an analyte, comprising a step of measuring a detectable substance by using a reaction system including a formation reaction of the detectable substance based on a chemical reaction of the analyte contained in a sample, wherein a layered inorganic compound is caused to exist in the reaction system including the formation reaction of the detectable substance, whereby high-sensitivity measurement is made possible, the detectable substance can be stabilized to improve accuracy of the measurement, a rate of a chemical reaction is increased to enable quick measurement, and high-sensitivity measurement is made possible even in a reaction system which forms an insoluble substance. Also, it can be provided an analytical testing piece for measuring an analyte, by measuring a detectable substance by using, a reaction system including a formation reaction of the detectable substance based on a chemical reaction of the analyte contained in a sample, wherein the testing piece comprises at least one test portion having a detection portion for detecting the detectable substance and contains a layered inorganic compound at least in the test portion, whereby diffusion and elution of a dyestuff or the like is prevented, more sensitive and accurate simple analysis is made possible, and easy handling is possible.

  一种测量被分析物的方法，包括以下步骤：根据样品中含有的被分析物的化学反应，使用包括可检测物质的形成反应的反应系统测量可检测物质，其中在包括可检测物质的形成反应的反应系统中导致层状无机化合物的存在、从而实现高灵敏度测量，稳定可检测物质以提高测量精度，提高化学反应速率以实现快速测量，即使在形成不溶性物质的反应体系中也能实现高灵敏度测量。此外，还可以提供一种用于测量被分析物的分析检测件，通过使用反应系统测量可检测物质，该反应系统包括基于样品中所含被分析物的化学反应的可检测物质的形成反应，其中检测件包括至少一个测试部分，该测试部分具有用于检测可检测物质的检测部分，并且至少在测试部分中包含分层无机化合物，从而防止染料或类似物的扩散和洗脱，实现更灵敏、更准确的简单分析，并且易于处理。