(3S)-4-oxo-3-phenylpentanoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: (3S)-4-oxo-3-phenylpentanoic acid
• 化学式: C₁₁H₁₂O₃
• 分子量: 192.21
• InChiKey: XXFBNFPEZIQQFY-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• INHIBITORS OF TRANSGLUTAMINASES
  申请人：Zedira GmbH

  公开号：EP3342779A1

  公开（公告）日：2018-07-04

  The invention relates to the compound of general formula (I) as novel inhibitors of transglutaminases, to methods for producing the inventive compounds, to pharmaceutical compositions containing said inventive compounds and to their use for the prophylaxis and treatment of diseases associated with transglutaminases.

  这项发明涉及通式（I）的化合物作为新型转谷氨酰胺酶抑制剂，以及生产这些创新化合物的方法，含有这些创新化合物的药物组合物，以及它们用于预防和治疗与转谷氨酰胺酶相关疾病的用途。
• Inhibitors of transglutaminases
  申请人：Zedira GmbH

  公开号：US11072634B2

  公开（公告）日：2021-07-27

  The invention relates to the compound of general formula (I) as novel inhibitors of transglutaminases, to methods for producing the inventive compounds, to pharmaceutical compositions containing said inventive compounds and to their use for the prophylaxis and treatment of diseases associated with transglutaminases.

  本发明涉及作为新型转谷氨酰胺酶抑制剂的通式（I）化合物、生产本发明化合物的方法、含有所述本发明化合物的药物组合物以及它们在预防和治疗与转谷氨酰胺酶有关的疾病方面的用途。
• [EN] INHIBITORS OF TRANSGLUTAMINASES<br/>[FR] INHIBITEURS DE TRANSGLUTAMINASES
  申请人：ZEDIRA GMBH

  公开号：WO2018122419A1

  公开（公告）日：2018-07-05

  The invention relates to the compound of general formula (I) as novel inhibitors of transglutaminases, to methods for producing the inventive compounds, to pharmaceutical compositions containing said inventive compounds and to their use for the prophylaxis and treatment of diseases associated with transglutaminases.