(1S)-1,2-bis(4-methoxyphenyl)ethanamine

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (1S)-1,2-bis(4-methoxyphenyl)ethanamine
• 化学式: C₁₆H₁₉NO₂
• 分子量: 257.33
• InChiKey: HKSKSPMTGBSDOR-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• CHIRAL IRIDIUM AQUA COMPLEX AND METHOD FOR PRODUCING OPTICALLY ACTIVE HYDROXY COMPOUND USING THE SAME
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2311846A1

  公开（公告）日：2011-04-20

  The present invention provides a novel chiral iridium aqua complex which has good preservation stability, can be easily produced and enables asymmetric transfer hydrogenation in a higher yield and with higher stereoselectivity. The present invention provides a chiral iridium aqua complex represented by the formula (1A): wherein Ra, Rb, Rc, Rd and Re are the same or different and each is a hydrogen atom, a methyl group, an ethyl group or a phenyl group, R1 and R2 are the same or different and each is an aryl group optionally having substituent(s), or R1 and R2 in combination show a C3-4 straight chain alkylene group optionally having substituent(s) to form a ring, R3 is an alkylsulfonyl group optionally having substituent(s) or an arylsulfonyl group optionally having substituent(s), R4 is a hydrogen atom, an alkylsulfonyl group optionally having substituent(s) or an arylsulfonyl group optionally having substituent(s), X is a monovalent or divalent anion, and n is 2 when X is a monovalent anion, or n is 1 when X is a divalent anion, and a production method of an optically active hydroxy compound using the complex.

  本发明提供了一种新型手性铱水络合物，该络合物具有良好的保存稳定性，易于生产，并能以更高的产率和立体选择性进行不对称转移加氢反应。 本发明提供了一种由式（1A）表示的手性铱水络合物： 其中 Ra、Rb、Rc、Rd 和 Re 相同或不同，且各自为氢原子、甲基、乙基或苯基、 R1 和 R2 相同或不同，且各自为可选具有取代基的芳基，或 R1 和 R2 组合在一起显示一个 C3-4 直链亚烷基，该亚烷基可选择具有取代基，以形成一个环、 R3 是可选具有取代基的烷基磺酰基或可选具有取代基的芳基磺酰基、 R4 是氢原子、任选具有取代基的烷基磺酰基或任选具有取代基的芳基磺酰基、 X 是一价或二价阴离子，以及 当 X 为一价阴离子时，n 为 2；当 X 为二价阴离子时，n 为 1、 以及使用该配合物生产光学活性羟基化合物的方法。