4-(6-Chloropyrido[3,2-d]pyrimidin-4-yl)-N-(3-methylphenyl)-1-piperazinecarboxamide | 1000797-06-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(6-Chloropyrido[3,2-d]pyrimidin-4-yl)-N-(3-methylphenyl)-1-piperazinecarboxamide
• 英文别名: 4-(6-chloropyrido[3,2-d]pyrimidin-4-yl)-N-(3-methylphenyl)piperazine-1-carboxamide
• CAS: 1000797-06-7
• 化学式: C₁₉H₁₉ClN₆O
• 分子量: 382.8
• InChiKey: DIQXGUXZJFUYRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  74.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR MEDICAL TREATMENT
  申请人：De Jonghe Steven Cesar Alfons

  公开号：US20090036430A1

  公开（公告）日：2009-02-05

  This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-α related disorders, viral diseases (including hepatitis C), erectile dysfunction and cell proliferative disorders.

  本发明涉及取代的吡啶并(3,2-d)嘧啶衍生物、它们的药学上可接受的盐、N-氧化物、溶剂化合物、前药和对映体，具有意外的理想药理特性，特别是高度活性的免疫抑制剂，因此在移植排斥和/或治疗某些炎症性疾病方面非常有用。这些衍生物还可用于预防或治疗心血管疾病、中枢神经系统疾病、TNF-α相关疾病、病毒性疾病（包括丙型肝炎）、勃起功能障碍和细胞增殖性疾病。
• [EN] PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR MEDICAL TREATMENT<br/>[FR] PYRIDO(3,2-D)PYRIMIDINES ET COMPOSITIONS PHARMACEUTIQUES UTILES POUR UN TRAITEMENT MÉDICAL
  申请人：4 AZA IP NV

  公开号：WO2009003669A2

  公开（公告）日：2009-01-08

  This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-α related disorders, viral diseases (including hepatitis C), erectile dysfunction and cell proliferative disorders.