1-[(2R)-5-phenyl-2,3-dihydro-1,3,4-thiadiazol-2-yl]naphthalen-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-[(2R)-5-phenyl-2,3-dihydro-1,3,4-thiadiazol-2-yl]naphthalen-2-ol
• 化学式: C₁₈H₁₄N₂OS
• 分子量: 306.4
• InChiKey: QIHMPEZAXBQNBF-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  69.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• AGENTS FOR REVERSING EPIGENETIC SILENCING OF GENES
  申请人：The Johns Hopkins University

  公开号：US20150252438A1

  公开（公告）日：2015-09-10

  The present invention provides methods for discovering agents that are effective in reversing epigenetic silencing by inhibiting the interaction of methyl-binding (MBD) proteins with methylated genomic DNA. Also provided are methods for reactivating silenced genes having CpG island hypermethylation along with methods for treatment and prevention of diseases, such as cancer and sickle cell anemia, by administering an agent that modulates methyl-binding domain (MBD) protein-mediated transcriptional repression, thereby increasing gene transcription to prevent or treat disease. Additionally, compounds identified by the present invention useful for treatment and prevention of diseases, such as cancer and sickle cell anemia, are provided.