(S)-benzofuran-2-carboxylic acid [3-(3-benzofuran-2-yl-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulen-8-yl)-2-oxo-oxazolidin-5-ylmethyl]-amide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: (S)-benzofuran-2-carboxylic acid [3-(3-benzofuran-2-yl-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulen-8-yl)-2-oxo-oxazolidin-5-ylmethyl]-amide
• 英文别名: N-[[(5S)-3-[5-(1-benzofuran-2-yl)-3,4-diazatricyclo[8.4.0.02,6]tetradeca-1(10),2,5,11,13-pentaen-12-yl]-2-oxo-1,3-oxazolidin-5-yl]methyl]-1-benzofuran-2-carboxamide
• 化学式: C₃₃H₂₆N₄O₅
• 分子量: 558.593
• InChiKey: AAZOXZJUFDIZHR-QHCPKHFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  42
• 可旋转键数：
  5
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  benzofuran-2-carboxylic acid {3-[6(R,S)-(benzofuran-2-carbonyl)-5-oxo-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl]-2-oxo-oxazolidin-5(S)-ylmethyl}-amide 在 一水合肼 作用下， 以 乙醇 为溶剂， 生成 (S)-benzofuran-2-carboxylic acid [3-(3-benzofuran-2-yl-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulen-8-yl)-2-oxo-oxazolidin-5-ylmethyl]-amide
  参考文献：
  名称：

  Synthesis and SAR of novel conformationally-restricted oxazolidinones possessing Gram-positive and fastidious Gram-negative antibacterial activity. Part 1: Substituted pyrazoles

  摘要：

  A novel series of conformationally-restricted oxazolidinones was synthesized which possess a fused pyrazole ring substituted with various alkyl, aryl and heteroaryl substituents. A number of analogs exhibited potent activity against both Gram-positive and fastidious Gram-negative organisms.(c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.05.056