1,3-di(4-chlorophenyl)-2-naphthol

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1,3-di(4-chlorophenyl)-2-naphthol
• 英文别名: 1,3-Bis(4-chlorophenyl)naphthalen-2-ol
• 化学式: C₂₂H₁₄Cl₂O
• 分子量: 365.259
• InChiKey: AICBRSOCTMPWRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1,3-di(4-chlorophenyl)-2-propanone 、 邻溴苯甲醛 在 palladium diacetate 、 potassium carbonate 、 三苯基膦 作用下， 以 邻二甲苯 为溶剂， 反应 8.0h， 以45%的产率得到1,3-di(4-chlorophenyl)-2-naphthol
  参考文献：
  名称：

  Palladium-Catalyzed Annulation Reaction of o-Bromobenzaldehydes with Carbonyl Compounds to Produce Naphthol and/or Naphthalene Derivatives

  摘要：

  o-Bromobenzaldehydes undergo annulation with 1,3-diaryl-2-propanones in the presence of a palladium catalyst to give the corresponding 1,3-diaryl-2-naphthols in fair to good yields. From the reaction of the aldehydes with 2-substituted 2-alkenals are formed 2,4-disubstituted 1-naphthols and/or 1,3-disubstituted naphthalenes accompanied by decarbonylation. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00043-0

文献信息

• Palladium-Catalyzed Annulation Reaction of o-Bromobenzaldehydes with Carbonyl Compounds to Produce Naphthol and/or Naphthalene Derivatives
  作者：Yoshito Terao、Tetsuya Satoh、Masahiro Miura、Masakatsu Nomura

  DOI：10.1016/s0040-4020(00)00043-0

  日期：2000.3

  o-Bromobenzaldehydes undergo annulation with 1,3-diaryl-2-propanones in the presence of a palladium catalyst to give the corresponding 1,3-diaryl-2-naphthols in fair to good yields. From the reaction of the aldehydes with 2-substituted 2-alkenals are formed 2,4-disubstituted 1-naphthols and/or 1,3-disubstituted naphthalenes accompanied by decarbonylation. (C) 2000 Elsevier Science Ltd. All rights reserved.