三氯三聚氰胺 | 7673-09-8

• 物质功能分类: 生物 - 细胞培养 - 添加剂
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 中文名称: 三氯三聚氰胺
• 中文别名: N~2~,N~2~,N~4~-三氯-1,3,5-三嗪-2,4,6-三胺；三氯乙胺；2,4,6-三(氯代氨基)-1,3,5-三嗪
• 英文名称: Trichloromelamine
• 英文别名: 2-N,4-N,6-N-trichloro-1,3,5-triazine-2,4,6-triamine
• CAS: 7673-09-8；12379-38-3
• 化学式: C₃H₃Cl₃N₆
• mdl: MFCD00006047
• 分子量: 229.45
• InChiKey: KEPNSIARSTUPGS-UHFFFAOYSA-N

物化性质

• 熔点：
  >300 °C(lit.)
• 沸点：
  368.35°C (rough estimate)
• 密度：
  1.9979 (rough estimate)
• 物理描述：
  Trichloromelamine appears as white or off-white to yellow fine powder with a chlorine odor. pH of saturated aqueous solution: 4. (NTP, 1992)
• 溶解度：
  less than 1 mg/mL at 66° F (NTP, 1992)
• 自燃温度：
  320 °F (NTP, 1992)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.8
• 氢给体数：
  3
• 氢受体数：
  6

ADMET

毒理性

• 副作用

职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒案例。

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 毒性数据

LC50 (rat) = 400 mg/m3 大白鼠LC50=400毫克/立方米

LC50 (rat) = 400 mg/m3

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

安全信息

• 危险等级：
  5.1
• 危险品标志：
  O,Xn
• 危险类别码：
  R36/37/38,R22,R8
• 危险品运输编号：
  UN 1479
• WGK Germany：
  3
• RTECS号：
  XZ1575000
• 海关编码：
  2933699090
• 包装等级：
  II
• 危险类别：
  5.1
• 安全说明：
  S17,S26,S36

反应信息

• 作为反应物：
  描述：

  三氯三聚氰胺 、 4-氯丁酰氯 、 在 氩 、 正己烷 作用下， 以 hexanes 、 四氯化碳 为溶剂， 反应 5.5h， 生成 N,N',N"-tris(4-chlorobutyryl)melamine
  参考文献：
  名称：

  Crosslinked film of tris-pyrrolidonyl triazine and polyfunctional active

  摘要：

  一种制备三噁烷交联剂三吡咯烷基三嗪的过程，从N,N'，N"-三（4-氯丁酰基）三聚氰胺通过用碱（如碳酸钠或碳酸钾）处理氯丁酰衍生物来实现分子内环化到三噁烷。所述可固化组合物包括三吡咯烷基三嗪作为交联剂和羟基官能或氨基官能材料作为树脂。使用粉末涂覆技术从可固化组合物制备无针孔的厚膜。

  公开号：

  US06107369A1

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• PRODRUGS COMPRISING AN INSULIN LINKER CONJUGATE
  申请人：SANOFI-AVENTIS DEUTSCHLAND GMBH

  公开号：US20150258207A1

  公开（公告）日：2015-09-17

  The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof comprising an insulin linker conjugate D-L, wherein D represents the insulin moiety; and -L is a non-biologically active linker moiety -L 1 represented by formula (I), wherein the dashed line indicates the attachment to one of the amino groups of the insulin by forming an amide bond. The invention further relates to pharmaceutical compositions comprising said prodrugs as well as their use as a medicament for treating or preventing diseases or disorders which can be treated by insulin.

  本发明涉及一种前药或其药用可接受的盐，包括胰岛素连接物D-L，其中D代表胰岛素部分；-L是一种非生物活性的连接物-L1，其由式(I)表示，虚线表示通过形成酰胺键与胰岛素的氨基团之一结合。该发明还涉及包括所述前药的药物组合物，以及它们作为治疗或预防可以通过胰岛素治疗的疾病或紊乱的药物的用途。
• [EN] INHIBITORS OF HISTONE DEACETYLASE<br/>[FR] INHIBITEURS D'HISTONE DÉSACÉTYLASE
  申请人：METHYLGENE INC

  公开号：WO2005092899A1

  公开（公告）日：2005-10-06

  The invention relates to a series of compounds useful for inhibiting histone deacetylase (HDAC) enzymatic activity. The invention also provides a method for inhibiting histone descetylase in a cell using said compounds as well as a method for treating cell proliferative diseases and conditions using said HDAC inhibitors. Further, the invention provides pharmaceutical compositions comprising the HDAC inhibiting compounds and a pharmaceutically acceptable carrier.

  这项发明涉及一系列对抑制组蛋白去乙酰化酶（HDAC）酶活性有用的化合物。该发明还提供了一种利用这些化合物抑制细胞中组蛋白去乙酰化酶的方法，以及一种利用这些HDAC抑制剂治疗细胞增殖性疾病和病况的方法。此外，该发明提供了包含这些HDAC抑制化合物和药用可接受载体的药物组合物。
• N-HALAMINE MELAMINE DERIVATIVES AS NOVEL DECONTAMINATION AND BIOCIDAL AGENTS
  申请人：State of Israel Prime Minister's Office Israel Institute For Biological Research

  公开号：US20180105618A1

  公开（公告）日：2018-04-19

  The present disclosure relates to the field of decontamination and biocidal agents. More specifically, the invention relates to novel N-halamine melamine derivatives, compositions comprising them, processes for their production, and methods using the same.

  本公开涉及脱污和杀菌剂领域。更具体地，本发明涉及新型N-卤胺三聚氰胺衍生物，包括它们的组合物，其生产过程以及使用相同的方法。
• Inhibitors of histone deacetylase
  申请人：MethylGene, Inc.

  公开号：US20040142953A1

  公开（公告）日：2004-07-22

  The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

  这项发明涉及抑制组蛋白去乙酰化酶。该发明提供了抑制组蛋白去乙酰化酶酶活性的化合物和方法。该发明还提供了用于治疗细胞增殖性疾病和病况的组合物和方法。

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