6-isobutylnaphthalen-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-isobutylnaphthalen-2-ol
• 英文别名: 6-(2-Methylpropyl)naphthalen-2-ol
• 化学式: C₁₄H₁₆O
• 分子量: 200.28
• InChiKey: AVHLNHPZGMKWMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  6-isobutylnaphthalen-2-ol 在 硫酸 、 双氧水 、 potassium iodide 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Pd 催化苯酚不对称环脱芳构化用于区域和对映选择性合成螺环己二酮

  摘要：

  据报道，钯催化的苯酚与丁烯二碳酸酯的不对称环环脱芳构化反应能够实现双重脱羧烯丙基化，从而区域选择性地产生一系列螺环己二酮，产率为 29-95%，ee 为 74-99%。1,1'-联苯-2,4'-二醇的催化脱芳香形式[4 + 2]环化生成螺[苯并二氢吡喃-4,1'-环己烷]-2',5'-二烯-4'-酮高对映选择性，而对映体富集的螺[环己烷-1,4'-喹啉]-2,5-二烯-4-酮是从2'-氨基-[1,1'-联苯]-4-醇开始生成的，为1， 4-双亲核试剂。

  DOI：

  10.1021/acs.orglett.3c02051
• 作为产物：
  描述：

  6-溴-2-萘酚 、 异丁基硼酸 在 palladium diacetate 、 二异丙胺 作用下， 以 水 为溶剂， 反应 10.0h， 生成 6-isobutylnaphthalen-2-ol
  参考文献：
  名称：

  手性钴（Ⅱ）配合物催化Friedel-Crafts芳构化反应合成轴向手性联芳二醇

  摘要：

  通过对苯二酚和2-萘酚之间的不对称Friedel-Crafts芳构化，有效地合成了轴向手性联芳二醇。N，N'-二氧化物的手性钴（II）配合物使该方法能够以高达98％的收率和95％的ee生成轴向手性联芳基二醇。在对苯醌和2-萘酚的不同位置处的大范围的取代基是可容忍的。通过X射线晶体衍射分析确定了产物和手性N，N'-二氧化物-Co（ClO 4）2催化剂的构型，并提出了可能的催化模型。

  DOI：

  10.1039/c7cc05266a

文献信息

• CATALYST FOR OLEFIN POLYMERIZATION AND METHOD OF PREPARATION THEREOF
  申请人：Wang Licai

  公开号：US20110301385A1

  公开（公告）日：2011-12-08

  A catalyst for olefin polymerization and method of preparing the same are disclosed.

  揭示了一种烯烃聚合的催化剂及其制备方法。
• Fluorescent Substrates for Monoamine Transporters as Optical False Neurotransmitters
  申请人：Gubernator Niko Gert

  公开号：US20100035279A1

  公开（公告）日：2010-02-11

  The present invention relates to compounds of the general structure: wherein Y is O, X is O, bond α is absent and bond β is present, or Y is H, X is CH, bond α is present, and bond β is absent; atom Z is a carbon and bonds χ, δ and γ are present, or is a nitrogen and bonds χ, δ and γ are absent; R 1 is —H, —OH, —O—R 7 , —N(H)—R 8 , —N(H)—(CH 2 ) n —NH 2 , —N(R 9 )(R 10 ), or a piperazine cation; R 2 is either covalently bound to R 9 , or is —H, or is covalently bound to R 3 so as to form a substituted or unsubstituted pyrrole or R 2 is covalently bound to R 9 or R 8 or R 7 ; or R 1 and R 2 are covalently joined to form an aromatic ring; R 3 is either covalently bound to R 2 so as to form a pyrrole, or is, inter alia, —H, —OH, alkyl, or when Z is nitrogen R 3 is ═O; R 4 is, inter alia, —H, —OH, or —R 11 NH 2 ; R 5 is, inter alia, —H, —OH, or —R 12 NH 2 , and R 6 is either is covalently bound to R 10 or is —H, or R 6 is covalently bound to R 10 or R 8 or R 7 . This invention also provides processes for making the compounds as well as methods for monitoring activity of monoamine transporters or treating monoamine transporter-associated diseases by employing the compounds.

  本发明涉及一般结构的化合物：其中Y为O，X为O，α键不存在且β键存在，或者Y为H，X为CH，α键存在且β键不存在；原子Z为碳，键χ，δ和γ存在，或为氮，键χ，δ和γ不存在；R1为-H，-OH，-O-R7，-N（H）-R8，-N（H）-（CH2）n-NH2，-N（R9）（R10）或哌嗪阳离子；R2要么与R9共价结合，要么为-H，要么与R3共价结合以形成取代或未取代的吡咯，或者R2与R9或R8或R7共价结合形成芳香环；R1和R2共价结合形成芳香环；R3要么与R2共价结合形成吡咯，要么为-H，-OH，烷基，或当Z为氮时，R3为═O；R4为-H，-OH或-R11NH2；R5为-H，-OH或-R12NH2，R6要么与R10共价结合，要么为-H，或者R6与R10或R8或R7共价结合。本发明还提供制备这些化合物的方法，以及利用这些化合物监测单胺转运体活性或治疗单胺转运体相关疾病的方法。
• Catalyst for Olefin Polymerization and Preparation Thereof and Polymerization Process
  申请人：Wang Licai

  公开号：US20080161513A1

  公开（公告）日：2008-07-03

  The catalyst for olefin polymerization contains three components A, B and C. The component A is a solid catalyst containing titanium, magnesium, chlorine element and an internal electron donor, the internal electron donor consists of 1,4-diether [2,2′-dialkoxy-1,1′-biphenyl, 2,2′-dialkoxy-1,1′-binaphthalene, 10,10′-dialkoxy-9,9-biphenanthrene] and organic acid ester or 1,3-diether [9,9-bis(methoxymethyl)fluorine, 2,2-dialky 1-1,3-dimethoxypropane]; the component B is an organoaluminum compound; the component C is external electron donor-organic silicon compound or the 1,4 aromatic diether. The catalyst has high catalytic activity, and can be adjusted in the range from 40,000 to 150,000 gPP/gCat when used in propylene polymerization. The polymer made therefrom has isotactivity of 80 to 99 percent and the molecular weight distribution can be adjusted in a wide range. The invention provides a novel method for preparing the 1,4 aromatic diether.

  烯烃聚合反应的催化剂包含三个组分A、B和C。组分A是一种固体催化剂，包含钛、镁、氯元素和内部电子给体。内部电子给体由1,4-二醚[2,2'-二烷氧基-1,1'-联苯、2,2'-二烷氧基-1,1'-联萘、10,10'-二烷氧基-9,9-联苯并]和有机酸酯或1,3-二醚[9,9-双(甲氧基甲基)氟、2,2-二烷基-1,3-二甲氧基丙烷]组成；组分B是一种有机铝化合物；组分C是外部电子给体-有机硅化合物或1,4-芳香二醚。该催化剂具有高催化活性，在丙烯聚合中使用时，可以在40,000至150,000 gPP/gCat的范围内调整。由此制成的聚合物具有80至99％的同构活性，分子量分布范围可以广泛调整。本发明提供了一种制备1,4-芳香二醚的新方法。
• FLUORESCENT SUBSTRATES FOR MONOAMINE TRANSPORTERS AS OPTICAL FALSE NEUROTRANSMITTERS
  申请人：of New York The Trustees of Columbia University in the City

  公开号：US20130190497A1

  公开（公告）日：2013-07-25

  The present invention relates to compounds of the general structure: wherein Y is O, X is O, bond α is absent and bond β is present, or Y is H, X is CH, bond α is present, and bond β is absent; atom Z is a carbon and bonds χ, δ and γ are present, or is a nitrogen and bonds χ, δ and γ are absent; R 1 is —H, —OH, —O—R 7 , —N(H)—R 8 , —N(H)—(CH 2 ) n —NH 2 , —N(R 9 )(R 10 ), or a piperazine cation; R 2 is either covalently bound to R 9 , or is —H, or is covalently bound to R 3 so as to form a substituted or unsubstituted pyrrole or R 2 is covalently bound to R 9 or R 8 or R 7 ; or R 1 and R 2 are covalently joined to form an aromatic ring; R 3 is either covalently bound to R 2 so as to form a pyrrole, or is, inter alia, —H, —OH, alkyl, or when Z is nitrogen R 3 is ═O; R 4 is, inter alia, —H, —OH, or —R 11 NH 2 ; R 5 is, inter alia, —H, —OH, or —R 12 NH 2 , and R 6 is either is covalently bound to R 10 or is —H, or R 6 is covalently bound to R 10 or R 8 or R 7 . This invention also provides processes for making the compounds as well as methods for monitoring activity of monoamine transporters or treating monoamine transporter-associated diseases by employing the compounds.

  本发明涉及以下通用结构的化合物：其中Y为O，X为O，键α不存在，键β存在，或Y为H，X为CH，键α存在，键β不存在；原子Z为碳并存在键χ，δ和γ，或为氮并不存在键χ，δ和γ；R1为—H，—OH，—O—R7，—N(H)—R8，—N(H)—(CH2)n—NH2，—N(R9)(R10)，或哌嗪阳离子；R2要么与R9共价结合，要么为—H，要么与R3共价结合以形成取代或未取代的吡咯，或R2与R9或R8或R7共价结合；或R1和R2共价结合以形成芳香环；R3要么与R2共价结合以形成吡咯，要么为—H，—OH，烷基，或者当Z为氮时，R3为═O；R4为—H，—OH，或—R11NH2；R5为—H，—OH，或—R12NH2，R6要么与R10共价结合，要么为—H，要么与R10或R8或R7共价结合。本发明还提供制备这些化合物的方法以及利用这些化合物监测单胺转运体活性或治疗单胺转运体相关疾病的方法。
• US7964678B2
  申请人：——

  公开号：US7964678B2

  公开（公告）日：2011-06-21