7-(hydroxymethyl)-2,4,6-triphenyl-1,3,5-triazaadamantane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 7-(hydroxymethyl)-2,4,6-triphenyl-1,3,5-triazaadamantane
• 英文别名: (2,4,6-Triphenyl-1,3,5-triazatricyclo[3.3.1.13,7]decan-7-yl)methanol
• 化学式: C₂₆H₂₇N₃O
• 分子量: 397.52
• InChiKey: BDHLZDOSNKKSFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  30
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,2′,2″-tri(aminomethyl)ethanol trihydrochloride 、 苯甲醛 在 三乙胺 作用下， 以 甲醇 为溶剂， 反应 0.33h， 生成 7-(hydroxymethyl)-2,4,6-triphenyl-1,3,5-triazaadamantane
  参考文献：
  名称：

  pH-Responsive Fe₃O₄ Nanopartilces-Capped Mesoporous Silica Supports for Protein Delivery

  摘要：

  Delivery of proteins and peptides with excellent bioactivity and controlled release still is a great challenge nowadays. In this study, a pH-responsive delivery system obtained by anchoring 8-nm Fe3O4 nanoparticles (NPs) onto SBA-15 supports with a particle diameter in the range of 0.6-1 mu m and a pore size of 6.2 nm was synthesized and investigated. The pH-stimulative response is based on the interaction between the tris(aminomethyl) ethane (TAE) groups anchored onto the pore outlet of mesoporous silica scaffolds and the carboxybenzaldehyde (CBA) groups coated on the Fe3O4 NPs, which can lead to a rapid release under the acid condition (pH=5) and a zero release with the increase of pH value (pH = 7.4). With BMP-2 as a model protein, this Fe3O4 nanopartilces-capped mesoporous silica showed a rapid response to the change of pH for protein delivery. Furthermore, the released BMP-2 could still maintain its bioactivity and induce the osteoblast differentiation of BMSCs. Besides, the magnetic orientation mainly attributes to the Fe3O4 NPs served as the nanocaps. The excellent bio-compatibility is demonstrated by the MTT assay on BMSCs model cells. These results show that Fe3O4 NPs-capped SBA-15 materials have an effective load for large molecule size proteins, such as BMP-2, and show an excellent applied prospect in pH-responsive controlled release system.

  DOI：

  10.1166/jnn.2016.11744

文献信息

• Chemically modified enzymes with multiple charged variants
  申请人：GenenCor International, Inc.

  公开号：US20020127695A1

  公开（公告）日：2002-09-12

  This invention provides modified enzymes comprising one or more amino acid residues replaced by cysteine residues, where the cysteine residues are modified by replacing the thiol hydrogen in the cysteine residues with a substituent group providing a thiol side chain comprising a multiply charged moiety. The enzymes show improved interaction and/or specificity and/or activity with charged substrates.

  这项发明提供了一种改良酶，其中一个或多个氨基酸残基被半胱氨酸残基取代，半胱氨酸残基被替换为含有多重带电基团的硫醇侧链取代基，从而改良了酶与带电底物的相互作用和/或特异性和/或活性。
• CHEMICALLY MODIFIED ENZYMES WITH MULTIPLE CHARGED VARIANTS
  申请人：GENENCOR INTERNATIONAL, INC.

  公开号：EP1141335A2

  公开（公告）日：2001-10-10
• US6379942B1
  申请人：——

  公开号：US6379942B1

  公开（公告）日：2002-04-30
• US7371553B2
  申请人：——

  公开号：US7371553B2

  公开（公告）日：2008-05-13
• [EN] CHEMICALLY MODIFIED ENZYMES WITH MULTIPLE CHARGED VARIANTS<br/>[FR] ENZYMES CHIMIQUEMENT MODIFIES AVEC VARIANTS A CHARGES MULTIPLES
  申请人：GENENCOR INT

  公开号：WO2000037658A2

  公开（公告）日：2000-06-29

  This invention provides modified enzymes comprising one or more amino acid residues replaced by cysteine residues, where the cysteine residues are modified by replacing the thiol hydrogen in the cysteine residues with a substituent group providing a thiol side chain comprising a multiply charged moiety. The enzymes show improved interaction and/or specificity and/or activity with charged substrates.