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9-{[(1-methylpiperidine-4-carbonyl)oxy] methyl}heptadecanedioic acid

中文名称
——
中文别名
——
英文名称
9-{[(1-methylpiperidine-4-carbonyl)oxy] methyl}heptadecanedioic acid
英文别名
9-[(1-Methylpiperidine-4-carbonyl)oxymethyl]heptadecanedioic acid;9-[(1-methylpiperidine-4-carbonyl)oxymethyl]heptadecanedioic acid
9-{[(1-methylpiperidine-4-carbonyl)oxy] methyl}heptadecanedioic acid化学式
CAS
——
化学式
C25H45NO6
mdl
——
分子量
455.635
InChiKey
BDRYZUULNVGTMN-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    3.3
  • 重原子数:
    32
  • 可旋转键数:
    20
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.88
  • 拓扑面积:
    104
  • 氢给体数:
    2
  • 氢受体数:
    7

反应信息

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文献信息

  • CATIONIC LIPID
    申请人:Eisai R&D Management Co., Ltd.
    公开号:EP3476832A1
    公开(公告)日:2019-05-01
    The present invention provides a cationic lipid which is able to be used for nucleic acid delivery to the cytoplasm. A cationic lipid according to the present invention is, for example, a compound represented by formula (1a) or a pharmaceutically acceptable salt thereof. (In formula (1a), each of L1 and L2 independently represent an alkylene group having 3-10 carbon atoms; each of R1 and R2 independently represent an alkyl group having 4-22 carbon atoms or an alkenyl group having 4-22 carbon atoms; X1 represents a single bond or -CO-O-; and ring P represents one of formulae (P-1) to (P-5).)(In formulae (P-1) to (P-5), R3 represents an alkyl group having 1-3 carbon atoms.)
    本发明提供了一种可用于将核酸递送至细胞质的阳离子脂质。根据本发明的阳离子脂质是例如由式(1a)代表的化合物或其药学上可接受的盐。(在式(1a)中,L1和L2各自独立地代表具有3-10个碳原子的亚烷基;R1和R2各自独立地代表具有4-22个碳原子的烷基或具有4-22个碳原子的烯基;X1代表单键或-CO-O-;环P代表式(P-1)至(P-5)之一。)(在式(P-1)至(P-5)中,R3代表具有1-3个碳原子的烷基)。
  • Cationic Lipid
    申请人:EISAI R&D MANAGEMENT CO., LTD.
    公开号:US20190218180A1
    公开(公告)日:2019-07-18
    The present invention provides a cationic lipid which is able to be used for nucleic acid delivery to the cytoplasm. A cationic lipid according to the present invention is, for example, a compound represented by formula (1a) or a pharmaceutically acceptable salt thereof. (In formula (1a), each of L 1 and L 2 independently represent an alkylene group having 3-10 carbon atoms; each of R 1 and R 2 independently represent an alkyl group having 4-22 carbon atoms or an alkenyl group having 4-22 carbon atoms; X 1 represents a single bond or —CO—O—; and ring P represents one of formulae (P-1) to (P-5).)(In formulae (P-1) to (P-5), R 3 represents an alkyl group having 1-3 carbon atoms.)
  • EP3476832
    申请人:——
    公开号:——
    公开(公告)日:——
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