9-{[(1-methylpiperidine-4-carbonyl)oxy] methyl}heptadecanedioic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 9-{[(1-methylpiperidine-4-carbonyl)oxy] methyl}heptadecanedioic acid
• 英文别名: 9-[(1-Methylpiperidine-4-carbonyl)oxymethyl]heptadecanedioic acid；9-[(1-methylpiperidine-4-carbonyl)oxymethyl]heptadecanedioic acid
• 化学式: C₂₅H₄₅NO₆
• 分子量: 455.635
• InChiKey: BDRYZUULNVGTMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  32
• 可旋转键数：
  20
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  辛醇 、 9-{[(1-methylpiperidine-4-carbonyl)oxy] methyl}heptadecanedioic acid 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以101 mg的产率得到dioctyl 9-{[(1-methylpiperidine-4-carbonyl)oxy]methyl}heptadecanedioate
  参考文献：
  名称：

  EP3476832

  摘要：

  公开号：
• 作为产物：
  描述：

  dibenzyl 9-{[(1-methylpiperidine-4-carbonyl)oxy]methyl}heptadecanedioate 在 palladium 10% on activated carbon 、 氢气 作用下， 以 乙醇 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 18.0h， 以0.58 g的产率得到9-{[(1-methylpiperidine-4-carbonyl)oxy] methyl}heptadecanedioic acid
  参考文献：
  名称：

  EP3476832

  摘要：

  公开号：

文献信息

• CATIONIC LIPID
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP3476832A1

  公开（公告）日：2019-05-01

  The present invention provides a cationic lipid which is able to be used for nucleic acid delivery to the cytoplasm. A cationic lipid according to the present invention is, for example, a compound represented by formula (1a) or a pharmaceutically acceptable salt thereof. (In formula (1a), each of L1 and L2 independently represent an alkylene group having 3-10 carbon atoms; each of R1 and R2 independently represent an alkyl group having 4-22 carbon atoms or an alkenyl group having 4-22 carbon atoms; X1 represents a single bond or -CO-O-; and ring P represents one of formulae (P-1) to (P-5).)(In formulae (P-1) to (P-5), R3 represents an alkyl group having 1-3 carbon atoms.)

  本发明提供了一种可用于将核酸递送至细胞质的阳离子脂质。根据本发明的阳离子脂质是例如由式（1a）代表的化合物或其药学上可接受的盐。(在式(1a)中，L1和L2各自独立地代表具有3-10个碳原子的亚烷基；R1和R2各自独立地代表具有4-22个碳原子的烷基或具有4-22个碳原子的烯基；X1代表单键或-CO-O-；环P代表式(P-1)至(P-5)之一。)(在式(P-1)至(P-5)中，R3代表具有1-3个碳原子的烷基)。
• Cationic Lipid
  申请人：EISAI R&D MANAGEMENT CO., LTD.

  公开号：US20190218180A1

  公开（公告）日：2019-07-18

  The present invention provides a cationic lipid which is able to be used for nucleic acid delivery to the cytoplasm. A cationic lipid according to the present invention is, for example, a compound represented by formula (1a) or a pharmaceutically acceptable salt thereof. (In formula (1a), each of L 1 and L 2 independently represent an alkylene group having 3-10 carbon atoms; each of R 1 and R 2 independently represent an alkyl group having 4-22 carbon atoms or an alkenyl group having 4-22 carbon atoms; X 1 represents a single bond or —CO—O—; and ring P represents one of formulae (P-1) to (P-5).)(In formulae (P-1) to (P-5), R 3 represents an alkyl group having 1-3 carbon atoms.)