(Z)-N-(3-(naphthalen-1-yl)-4-phenylthiazol-2(3H)-ylidene) benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (Z)-N-(3-(naphthalen-1-yl)-4-phenylthiazol-2(3H)-ylidene) benzamide
• 英文别名: 2-benzoylimino-3-α-naphthyl-4-phenyl-1,3-thiazoline
• 化学式: C₂₆H₁₈N₂OS
• 分子量: 406.508
• InChiKey: BHLDMVHPXOKXTO-RQZHXJHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  30.0
• 可旋转键数：
  3.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.36
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  苯甲酰氯 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 4.33h， 生成 (Z)-N-(3-(naphthalen-1-yl)-4-phenylthiazol-2(3H)-ylidene) benzamide
  参考文献：
  名称：

  新型 (4-phenylthiazol-2(3H)-ylidene) 苯甲酰胺和 ((benzoylimino)-3-(9,10-dioxo-9,10-dihydroanthracen-1-yl)-4-oxothiazolidin-5 的合成及晶体结构-亚叉基）乙酸酯衍生物

  摘要：

  AbstractA new approach to the synthesis of new heterocyclic compounds with benzoylisothiocyanate, amines, and 2‐bromoacetophenone (phenacyl bromide) fragments in one molecule has been developed. The synthesis method comprises condensation reaction for the preparation of novel (4‐phenylthiazol‐2(3H)‐ylidene) benzamide derivatives. These new compounds were synthesized via one‐pot and multicomponent reaction of 2‐furanmethylamine, 5‐chloro‐2‐phenoxyaniline, and 1‐naphthylamine with phenacyl bromide and substituted benzoylisothiocyanates. Moreover, new series of anthraquinone‐thiazole hybrids have been synthesized. These compounds were prepared from unsymmetrical thiourea containing anthraquinone and dialkyl acetylenedicarboxylate. The nature of the compounds was confirmed by IR, 1HNMR, 13CNMR, mass spectrometry, and CHNS elemental analysis. The structural elucidation was accomplished by single‐crystal X‐ray diffraction methods.

  DOI：

  10.1002/hc.21409

文献信息

• Synthesis and Crystal Structure of Some Novel 2-Aroylimino-3-aryl-4-phenyl-1,3-thiazolines
  作者：Aamer Saeed、Sabah Zaman、Michael Bolte

  DOI：10.1080/00397910802026212

  日期：2008.6.20

  An efficient synthesis of some novel 2-aroylimino-3-aryl-4-phenyl-1,3-thiazolines was carried out by base-catalyzed cyclization of 1-aroyl-3-arylthioureas with acetophenone in the presence of bromine. The structures were confirmed by spectroscopic data, elemental analyses, and in one case (2t) by single-crystal X-ray diffraction data.
• Synthesis and crystal structures of novel (4-phenylthiazol-2(3H)-ylidene) benzamide and ((benzoylimino)-3-(9,10-dioxo-9,10-dihydroanthracen-1-yl)-4-oxothiazolidin-5-ylidene)acetate derivatives
  作者：Mahshid Hossaini、Reza Heydari、Malek Taher Maghsoodlou、Majid Kolahdoozan、Claudia Graiff

  DOI：10.1002/hc.21409

  日期：2017.11

  AbstractA new approach to the synthesis of new heterocyclic compounds with benzoylisothiocyanate, amines, and 2‐bromoacetophenone (phenacyl bromide) fragments in one molecule has been developed. The synthesis method comprises condensation reaction for the preparation of novel (4‐phenylthiazol‐2(3H)‐ylidene) benzamide derivatives. These new compounds were synthesized via one‐pot and multicomponent reaction of 2‐furanmethylamine, 5‐chloro‐2‐phenoxyaniline, and 1‐naphthylamine with phenacyl bromide and substituted benzoylisothiocyanates. Moreover, new series of anthraquinone‐thiazole hybrids have been synthesized. These compounds were prepared from unsymmetrical thiourea containing anthraquinone and dialkyl acetylenedicarboxylate. The nature of the compounds was confirmed by IR, 1HNMR, 13CNMR, mass spectrometry, and CHNS elemental analysis. The structural elucidation was accomplished by single‐crystal X‐ray diffraction methods.