(R)-binaphthol

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (R)-binaphthol
• 英文别名: 12,14-Dioxa-13-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaene
• 化学式: C₂₀H₁₃O₂P
• 分子量: 316.296
• InChiKey: BODRWHJDVOMRMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  23
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-benzhydrylpropan-2-amine 、 (R)-binaphthol 在 三乙胺 、 三氯化磷 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以73%的产率得到N-benzhydryl-N-isopropyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine
  参考文献：
  名称：

  铜催化不对称共轭添加烷基锆试剂形成四元中心

  摘要：

  纯净和简单：由简单烯烃原位生成的烷基锆茂被用于高度对映选择性的铜催化的1,4加成反应，形成三取代的环烯酮，以生成季中心。这些反应在室温下在一定条件下进行，并能耐受许多官能团。Cp ＝环戊二烯基，Tf ＝三氟甲磺酰基。

  DOI：

  10.1002/anie.201303202

文献信息

• CARBOXYLATE METAL COMPLEX AND CATALYST FOR OLEFIN POLYMERIZATION
  申请人：Ito Shingo

  公开号：US20130158223A1

  公开（公告）日：2013-06-20

  The present invention provides a metal complex of group 10 elements of the periodic table having a carboxylate structure represented by formula (C2); a catalyst for polymerization of olefin mainly comprising the metal complex; and a method for producing polymers by homopolymerizing olefin represented by formula (1), polymerizing two or more kinds of the above olefin, or copolymerizing olefin represented by formula (1) with polar group-containing olefin represented by formula (2) (the meaning of the symbols are as set forth in the description) using the catalyst. A metal complex of group 10 elements of the periodic table, in which all of the coordinating atoms to the metal are a hetero atom is stable and useful as a catalyst component for olefin polymerization, and can be used for a long time in homopolymerization of olefin or copolymerization of two or more kinds of olefin.

  本发明提供了一种具有由式（C2）表示的羧酸盐结构的周期表第10族元素的金属配合物；主要包括所述金属配合物的烯烃聚合催化剂；以及通过使用所述催化剂，通过将由式（1）表示的烯烃进行均聚合，聚合两种或更多种上述烯烃，或将由式（1）表示的烯烃与由式（2）表示的含极性基团的烯烃进行共聚合来生产聚合物的方法。周期表第10族元素的金属配合物，其中与金属配位的所有原子均为杂原子，稳定且可用作烯烃聚合的催化剂组分，并可在烯烃的均聚合或两种或更多种烯烃的共聚合中长时间使用。
• [EN] ASYMMETRIC SYNTHESIS OF CHIRAL COMPOUNDS<br/>[FR] SYNTHÈSE ASYMÉTRIQUE DE COMPOSÉS CHIRAUX
  申请人：ISIS INNOVATION

  公开号：WO2015008097A1

  公开（公告）日：2015-01-22

  The present invention provides processes for the production of chiral compounds in a stereoisomeric excess, the processes comprising: (i) contacting a first compound comprising an alkene or alkyne bond with a hydrometallating agent, wherein the first compound and the hydrometallating agent are contacted under conditions such that the first compound is hydrometallated by said hydrometallating agent; and (ii) contacting the hydrometallated first compound with a second compound comprising an allylic group, wherein the hydrometallated first compound and the second compound are contacted under conditions such that they undergo an asymmetric allylic alkylation reaction in which a carbon atom of the hydrometallated first compound binds to a carbon atom of said allylic group, forming a stereoisomeric excess of a compound having a chiral centre in an allylic position, said chiral centre being located at the carbon atom bound by said first compound, wherein said asymmetric allylic alkylation reaction is performed in the presence of a metal catalyst comprising a chiral ligand. In particular, the present invention provides processes for the production of a stereoisomeric excess of a compound of the formula (IA), (IB), (IA') or (IB') as defined herein.

  本发明提供了用于在立体异构过剩中生产手性化合物的工艺，该工艺包括：（i）将包含烯烃或炔烃键的第一化合物与氢化金属试剂接触，其中第一化合物和氢化金属试剂在条件下接触，使得第一化合物被所述氢化金属试剂氢化；以及（ii）将氢化的第一化合物与包含烯丙基团的第二化合物接触，其中氢化的第一化合物和第二化合物在条件下接触，使它们经历不对称烯丙基烷基化反应，在该反应中，氢化的第一化合物的一个碳原子与所述烯丙基团的一个碳原子结合，形成具有手性中心的化合物的立体异构过剩，在所述手性中心位于所述第一化合物结合的碳原子处，其中所述不对称烯丙基烷基化反应在存在包含手性配体的金属催化剂的情况下进行。具体地，本发明提供了用于生产具有公式（IA）、（IB）、（IA'）或（IB'）的化合物的立体异构过剩的工艺。
• Novel stable compositions of water and oxygen sensitive compounds and their method of preparation
  申请人：Taber F. Douglass

  公开号：US20050288257A1

  公开（公告）日：2005-12-29

  The present application described a new formulation for oxygen and/or water sensitive compounds with an inert material such as paraffin. The new formulation provides stability for the oxygen and/or water sensitive compounds in the air and can be handled easily. The new formulation of the present invention is useful as ligands and/or catalysts for preparation of pharmaceuticals, agrochemical, other fine chemicals and other synthetic compounds.

  本申请描述了一种使用石蜡等惰性材料的氧和/或水敏感化合物新配方。这种新配方可使氧和/或水敏感化合物在空气中保持稳定，并且易于处理。本发明的新配方可用作配体和/或催化剂，用于制备药物、农用化学品、其他精细化学品和其他合成化合物。
• Phosphine compounds, complexes containing the phosphine compounds as ligands, and process for producing optically active aldehydes using the phosphine compounds or complexes
  申请人：Takasago International Corporation

  公开号：EP0684249B1

  公开（公告）日：2003-02-19
• PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED COMPOUNDS
  申请人：DSM IP Assets B.V.

  公开号：EP1506148B1

  公开（公告）日：2008-05-28