(2,3-dihydro-1,4-benzodioxin-6-yl)(4-methylphenyl)methanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: (2,3-dihydro-1,4-benzodioxin-6-yl)(4-methylphenyl)methanol
• 英文别名: (2,3-Dihydro-1,4-benzodioxin-6-yl)(4-methyl-phenyl)methanol；2,3-dihydro-1,4-benzodioxin-6-yl-(4-methylphenyl)methanol
• 化学式: C₁₆H₁₆O₃
• 分子量: 256.301
• InChiKey: BPGVJLAUHJOPJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2,3-dihydro-1,4-benzodioxin-6-yl)(4-methylphenyl)methanol 、 异丙醇 在 盐酸 作用下， 以 水 为溶剂， 反应 120.0h， 以100%的产率得到6-[isopropoxy(4-methylphenyl)methyl]-2,3-dihydro-1,4-benzodioxine
  参考文献：
  名称：

  Hydrochloric acid as an efficient catalyst for intermolecular condensation of alcohols. A simple and highly efficient synthesis of unsymmetrical ethers from benzylic alcohols and alkanols

  摘要：

  Benzylic alcohols and diarylmethanols with electron-donating substituents in the aromatic ring reacted with aliphatic alcohols in the presence of a catalytic amount of HCl to give the corresponding alkyl arylmethyl ethers. The reactivity of diarylmethanols in the intermolecular dehydration depended on the nature of substituents in the aromatic rings and structure of aliphatic alcohol.

  DOI：

  10.1134/s107042801509002x
• 作为产物：
  描述：

  2,3-Dihydro-1,4-benzodioxin-6-yl(4-methylphenyl)methanone 在 sodium tetrahydroborate 作用下， 以79%的产率得到(2,3-dihydro-1,4-benzodioxin-6-yl)(4-methylphenyl)methanol
  参考文献：
  名称：

  Hydrochloric acid as an efficient catalyst for intermolecular condensation of alcohols. A simple and highly efficient synthesis of unsymmetrical ethers from benzylic alcohols and alkanols

  摘要：

  Benzylic alcohols and diarylmethanols with electron-donating substituents in the aromatic ring reacted with aliphatic alcohols in the presence of a catalytic amount of HCl to give the corresponding alkyl arylmethyl ethers. The reactivity of diarylmethanols in the intermolecular dehydration depended on the nature of substituents in the aromatic rings and structure of aliphatic alcohol.

  DOI：

  10.1134/s107042801509002x

文献信息

• Hydrochloric acid as an efficient catalyst for intermolecular condensation of alcohols. A simple and highly efficient synthesis of unsymmetrical ethers from benzylic alcohols and alkanols
  作者：S. S. Mochalov、A. N. Fedotov、E. V. Trofimova、N. S. Zefirov

  DOI：10.1134/s107042801509002x

  日期：2015.9

  Benzylic alcohols and diarylmethanols with electron-donating substituents in the aromatic ring reacted with aliphatic alcohols in the presence of a catalytic amount of HCl to give the corresponding alkyl arylmethyl ethers. The reactivity of diarylmethanols in the intermolecular dehydration depended on the nature of substituents in the aromatic rings and structure of aliphatic alcohol.