1-formyl-4-(4'-tert-butylphenyl)piperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-formyl-4-(4'-tert-butylphenyl)piperazine
• 英文别名: 4-(4-Tert-butylphenyl)piperazine-1-carbaldehyde；4-(4-tert-butylphenyl)piperazine-1-carbaldehyde
• 化学式: C₁₅H₂₂N₂O
• 分子量: 246.352
• InChiKey: LWRDUPWMOXYZJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-叔丁基苯胺 、 二(2-氯乙基)胺盐酸盐 、 N,N-二甲基甲酰胺 反应 4.0h， 以62%的产率得到1-formyl-4-(4'-tert-butylphenyl)piperazine
  参考文献：
  名称：

  DMF·HCl as a versatile and straightforwardN- andO-formylating agent

  摘要：

  Inspired by the serendipitous isolation of N-formylpiperazines when we attempted the synthesis of a series of piperazines, we have developed a straightforward methodology for the N- and O- formylation of secondary cyclic amines, anilines and steroids, respectively. Such approach is based on the hitherto non-reported use of DMF center dot HCl complex, as a versatile and easily-available formylating system that can be stored without apparent loss of activity.

  DOI：

  10.1080/00397911.2020.1844901

文献信息

• [EN] ANTHELMINTIC AGENTS AND THEIR USE<br/>[FR] AGENTS ANTHELMINTHIQUES ET LEUR UTILISATION
  申请人：INTERVET INT BV

  公开号：WO2009077527A1

  公开（公告）日：2009-06-25

  This invention is directed to compounds and salts that are generally useful as anthelmintic agents or as intermediates in processes for making anthelmintic agents. This invention also is directed to processes for making the compounds and salts, pharmaceutical compositions and kits comprising the compounds and salts, uses of the compounds and salts to make medicaments, and treatments comprising the administration ofthe compounds and salts to animals in need of the treatments.

  该发明涉及一般用作驱虫剂或作为制备驱虫剂中间体的化合物和盐。该发明还涉及制备这些化合物和盐的工艺、包含这些化合物和盐的药物组合物和工具包、使用这些化合物和盐制作药物以及将这些化合物和盐用于需要治疗的动物的治疗方法。
• Compounds, compositions and methods comprising heteroaromatic derivatives
  申请人：Doyle Kevin James

  公开号：US20100144733A1

  公开（公告）日：2010-06-10

  The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-14 or encompassed by formulas I-XII) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

  本发明涉及用于治疗动物体内对抑制功能性囊性纤维化跨膜传导调节因子（CFTR）多肽敏感的疾病的组合物和方法，通过向需要治疗该疾病的哺乳动物中投与本文所定义的化合物的有效量（包括表1-14中列出的化合物或公式I-XII所包含的化合物）或其组合物，从而治疗该疾病。本发明特别涉及治疗腹泻和多囊肾病的方法。
• DMF·HCl as a versatile and straightforward<i>N</i>- and<i>O</i>-formylating agent
  作者：Dulce G. Ramírez-Vázquez、Omar Viñas-Bravo、Roxana Martínez-Pascual、Lemuel Pérez-Picaso、Karla Viridiana Castro-Cerritos

  DOI：10.1080/00397911.2020.1844901

  日期：2021.2.16

  Inspired by the serendipitous isolation of N-formylpiperazines when we attempted the synthesis of a series of piperazines, we have developed a straightforward methodology for the N- and O- formylation of secondary cyclic amines, anilines and steroids, respectively. Such approach is based on the hitherto non-reported use of DMF center dot HCl complex, as a versatile and easily-available formylating system that can be stored without apparent loss of activity.