乙基-delta-8-四氢大麻酚 | 51768-58-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 乙基-delta-8-四氢大麻酚
• 中文别名: 17-乙炔基-3-羰基雌-4-烯-17-基乙酸酯-17-乙炔基-3-甲氧基雌-1,3,5(10)-三烯-17-醇(1:1)
• 英文名称: Ethyl-delta-8-tetrahydrocannabinol
• 英文别名: (6aR,10aR)-3-ethyl-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
• CAS: 51768-58-2
• 化学式: C₁₈H₂₄O₂
• 分子量: 272.4
• InChiKey: DNTBFILTGOCICF-ZIAGYGMSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] NOVEL METHODS AND RELATED TOOLS FOR CBD CONVERSION TO THC<br/>[FR] NOUVELLES MÉTHODES ET OUTILS ASSOCIÉS POUR CONVERSION DE CBD EN THC
  申请人：ARIELIUM HEALTH LLC

  公开号：WO2020146907A1

  公开（公告）日：2020-07-16

  The present invention is directed to methods of producing THC from CBD utilizing non-harsh methodology and resulting in substantially increased yields, as well as devices built upon these novel methods. The methods and devices are material efficient, and in certain embodiments, solvent-free. In particular, in certain embodiments, these methods and related devices are suitable for commercial production of THC from CBD. Furthermore, in certain embodiments, the present invention provides methods of producing THC from CBD in manner that affords tunability to select the ratio of THC -8 to THC-9.

  本发明涉及利用非侵害性方法从CBD生产THC的方法，从而实现大幅增加产量，并基于这些新颖方法构建的设备。这些方法和设备具有材料高效性，在某些实施方式中是无溶剂的。特别是，在某些实施方式中，这些方法和相关设备适用于商业生产从CBD中提取THC。此外，在某些实施方式中，本发明提供了一种从CBD中生产THC的方法，以便可调整THC-8和THC-9比例的选择。
• Process for the production of cannabidiol and delta-9-tetrahydrocannabinol
  申请人：Purisys LLC

  公开号：US10844035B2

  公开（公告）日：2020-11-24

  The present disclosure relates to a cannabidiol compound and compositions thereof and processes for preparing the compound and compositions. The processes include an acid-catalyzed reaction of a suitably selected and substituted di-bromo-olivetol or derivative thereof with a suitably selected and substituted cyclic alkene to produce a dibromo-cannabidiol compound or derivative thereof. The dibromo-cannabidiol compound or derivative thereof can be produced in high yield, high stereospecificity, or both. It can then be converted under reducing conditions to a cannabidiol compound or derivatives thereof.

  本公开涉及一种大麻二酚化合物及其组合物，以及制备该化合物及其组合物的工艺。这些工艺包括将经适当选择和取代的二溴-橄榄醇或其衍生物与经适当选择和取代的环烯进行酸催化反应，生成二溴-大麻二酚化合物或其衍生物。二溴-卡那比醇化合物或其衍生物可以高产率、高立体特异性或两者兼而有之的方式生产。然后可在还原条件下转化为大麻二酚化合物或其衍生物。
• [EN] PREVENTION OF BACTERIAL GROWTH AND BIOFILM FORMATION BY LIGANDS THAT ACT ON CANNABINOIDERGIC SYSTEMS<br/>[FR] PRÉVENTION DE LA CROISSANCE BACTÉRIENNE ET DE LA FORMATION DE BIOFILM PAR DES LIGANDS QUI AGISSENT SUR LES SYSTÈMES CANNABINOÏDERGIQUES
  申请人：UNIV NORTH TEXAS

  公开号：WO2009158499A2

  公开（公告）日：2009-12-30

  A group of antimicrobial compounds shows effectiveness for preventing bacterial growth and bio film formation. In particular, the compounds are effective for preventing the growth of gram-positive bacteria, including methicillin-resistant Staphylococcus aureus ("MRSA") bacteria. The compounds include naturally-occurring compounds such as linoleyl ethanolamide, noladin ether, and anandamide, and man-made compounds such as CP55,640 [(-)- cis-3-[2-Hydroxy-4-(l, l-dimethylheptyl)phenyl]-tran s-4-(3-hydroxypropyl)cyclohexanol] and O- 2050 [(6aR,10aR)-3-(l-Methanesulfonylamino-4-hexyn-6-yl)-6a, 7,10,1 Oa-tetrahydro-6, 6,9- trimethyl-6H-dibenzo[b,d]pyran]. Because these antibacterial compounds have unique modes of action and/or unique chemical scaffolds compared to traditional antibiotics, they are extremely useful against bacteria having resistances to antibiotics.