2-(1-piperidinyl)ethoxyamine dihydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-(1-piperidinyl)ethoxyamine dihydrochloride
• 英文别名: 2-piperidin-1-ylethoxyamine dihydrochloride；2-(1-piperidyl)ethoxyamine dihydrochloride；O-[2-(1-piperidinyl)ethyl]hydroxylamine dihydrochloride；Hydroxylamine,o-[2-(1-piperidinyl)ethyl]-,hydrochloride；O-(2-piperidin-1-ylethyl)hydroxylamine;hydrochloride
• 化学式: C₇H₁₆N₂O*2ClH
• 分子量: 217.139
• InChiKey: XPFIABMJTFFAAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.78
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  氟哌啶醇 、 2-(1-piperidinyl)ethoxyamine dihydrochloride 在 吡啶 作用下， 以 乙醇 为溶剂， 反应 32.0h， 以43.3%的产率得到4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-(2-piperidin-1-ylethoxyimino)butyl]piperidin-4-ol
  参考文献：
  名称：

  Synthesis of some novel oxime ether derivatives and their activity in the ‘behavioral despair test’

  摘要：

  In this study, a new series of 2-aminoethyloxime ether derivatives of some aralkylketones was synthesized. Their structures have been elucidated by UV, IR, H-1-NMR, C-13-NMR, mass spectra and elementary analysis. These compounds were then screened for their inhibition of immobility as an indicator of possible antidepressant activities by using the 'behavioral despair test'. Results showed that all the new compounds decreased the immobility time, however, the inhibition observed with A03, A04 and H01 was significantly higher compared to fluvoxamine (p < 0.01). (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(98)80038-x
• 作为产物：
  描述：

  1-(2-氯乙基)哌啶盐酸盐 在 盐酸 、 potassium carbonate 作用下， 以 甲苯 为溶剂， 反应 42.0h， 生成 2-(1-piperidinyl)ethoxyamine dihydrochloride
  参考文献：
  名称：

  Favara; Nicola; Pappalardo, Farmaco, Edizione Scientifica, 1987, vol. 42, # 10, p. 697 - 708

  摘要：

  DOI：

文献信息

• Synthesis and Antiproliferative Evaluation of Certain Indeno[1,2-<i>c</i>]quinoline Derivatives. Part 2
  作者：Chih-Hua Tseng、Cherng-Chyi Tzeng、Chiao-Li Yang、Pei-Jung Lu、Hui-Ling Chen、Hao-Yi Li、You-Chung Chuang、Chia-Ning Yang、Yeh-Long Chen

  DOI：10.1021/jm1005447

  日期：2010.8.26

  activities has been observed for indeno[1,2-c]quinoline derivatives; (5) compound 8c induced DNA fragmentation may through caspase-3 activation, phosphorylation of the histone protein H2AX at Ser139 (γ-H2AX), and PARP cleavage; (6) compound 8c demonstrated significant tumor regression in the human breast xenograft model; (7) indeno[1,2-c]quinoline derivatives are a new class of molecules that have the

  合成了某些茚并[1,2- c ]喹啉衍生物，并对其抗增殖，DNA结合亲和力和拓扑异构酶（拓扑I和拓扑II）抑制活性进行了评估。初步结果如下：（1）在C 11的氨基烷氧基亚氨基侧链的取代基对于其中端胺优选为叔或环状五元吡咯烷基环的抗增殖活性是重要的；（2）在所评估的茚并[1,2- c ]喹啉衍生物中，（E）-6-羟基-9-甲氧基-11 H-茚并[1,2 - c ]喹啉-11-one O -2-（吡咯烷-1-基）乙基肟（8c）被发现是最具细胞毒性的药物之一，对SAS，A549和BT483的GI 50值分别为0.84、0.89和0.79μM，比喜树碱更具活性; （3）C 6上的取代基对于选择性细胞毒性至关重要，其中最优选OH基，而氢或哌嗪对癌细胞和底特律551均具有细胞毒性。（4）已观察到茚并[1,2- c ]喹啉衍生物的抗增殖活性，DNA结合亲和力和topo I和topo II抑制活性呈正相关
• 4-Phenylamino-benzaldoxime derivatives and uses thereof as mitogen-activated protein kinase kinase (mek) inhibitors
  申请人：Isshiki Yoshiaki

  公开号：US20070105859A1

  公开（公告）日：2007-05-10

  A compound of the present invention, or a pharmaceutically acceptable salt thereof is indicated by formula (1) below: wherein, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , Q, R 8 , and R 9 have the same meanings as R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , Q, R 8 , and R 9 in the specification.

  本发明的化合物或其药学上可接受的盐由下式（1）表示：其中，R1、R2、R3、R4、R5、R6、Q、R8和R9在说明书中具有与R1、R2、R3、R4、R5、R6、Q、R8和R9相同的含义。
• 4-ANILINOFURO[2,3-B]QUINOLINE DERIVATIVES, THEIR PREPARATION PROCESSES, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
  申请人：Tzeng Cherng-Chyi

  公开号：US20130172336A1

  公开（公告）日：2013-07-04

  Disclosed herein are novel 4-anilinofuro[2,3-b]quinoline derivatives of formula (I): or a pharmaceutically acceptable salt thereof, wherein each of the substituents is given the definition as set forth in the Specification and Claims. Also disclosed are the preparation processes of these derivatives and their uses in the manufacture of pharmaceutical compositions and in the treatment of cancers.

  本文披露了新型的4-苯胺基呋喃[2,3-b]喹啉衍生物，其化学式为(I):或其药学上可接受的盐，其中每个取代基的定义如规范和权利要求中所述。还披露了这些衍生物的制备过程以及它们在制造药物组合物和治疗癌症方面的用途。
• NOVEL 4-PHENYLAMINO-BENZALDOXIME DERIVATIVE AND USE THEREOF AS MEK INHIBITOR
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP1674452A1

  公开（公告）日：2006-06-28

  A compound of the present invention, or a pharmaceutically acceptable salt thereof is indicated by formula (1) below: wherein, R1, R2, R3, R4, R5, R6, Q, R8, and R9 have the same meanings as R1, R2, R3, R4, R5, R6, Q, R8, and R9 in the specification.

  本发明的化合物或其药学上可接受的盐如下式（1）所示： 其中，R1、R2、R3、R4、R5、R6、Q、R8 和 R9 与说明书中的 R1、R2、R3、R4、R5、R6、Q、R8 和 R9 具有相同的含义。
• Tuncbilek, Meral; Bozdag, Oya; Ayhan-Kilcigil, Guelguen, Arzneimittel-Forschung/Drug Research, 1999, vol. 49, # 10, p. 853 - 857
  作者：Tuncbilek, Meral、Bozdag, Oya、Ayhan-Kilcigil, Guelguen、Altanlar, Nurten、Buyukbingol, Erdem、Ertan, Rahmiye

  DOI：——

  日期：——