3-[1-(2-methoxyethyl)-2-methylindol-3-yl]-3-(2-methyl-4-diethylaminophenyl)phthalide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 3-[1-(2-methoxyethyl)-2-methylindol-3-yl]-3-(2-methyl-4-diethylaminophenyl)phthalide
• 英文别名: 3-[4-(diethylamino)-2-methylphenyl]-3-[1-(2-methoxyethyl)-2-methylindol-3-yl]-2-benzofuran-1-one
• 化学式: C₃₁H₃₄N₂O₃
• 分子量: 482.623
• InChiKey: SMPDZTQZLLQZJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  43.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-[4-(二乙基氨基)-2-甲基苯甲酰]苯甲酸 、 1-(β-methoxyethyl)-2-methylindole 生成 3-[1-(2-methoxyethyl)-2-methylindol-3-yl]-3-(2-methyl-4-diethylaminophenyl)phthalide
  参考文献：
  名称：

  HUNG, WILLIAM M.;BLACK, ANGELIQUE M.

  摘要：

  DOI：

文献信息

• Imaging systems containing 3-(indol-3-yl)-3-(4-substituted
  申请人：The Hilton-Davis Chemical Co.

  公开号：US04660060A1

  公开（公告）日：1987-04-21

  3-(1-R-2-R.sup.1 -5/6-Y-indol-3-yl)-3-(2-R.sup.2 -4-N-R.sup.3 -N-R.sup.4 -aminophenyl)-X-phthalides, 7-(1-R-2-R.sup.1 -5/6-Y-indol-3-yl)-7-(2-R.sup.2 -4-N-R.sup.3 -N-R.sup.4 -aminophenyl)furo[3,4b]-pyridine-5(7H)-ones and 5-(1-R-2-R.sup.1 -5/6-Y-indol-3-yl)-5-(2-R.sup.2 -4-N-R.sup.3 -N-R.sup.4 -aminophenyl)furo[3,4b]-pyridine-7(5H)-ones are useful as color formers in transfer imaging systems, pressure-sensitive carbonless duplicating systems and thermal-responsive marking systems. The phthalides are prepared by the interaction of the corresponding 2-(1-R-2-R.sup.1 -5/6-Y-indol-3-yl)carbonyl-X-benzoic acid with the corresponding 3-R.sup.2 -N-R.sup.3 -N-R.sup.4 -aniline or the interaction of the corresponding 2-(2-R.sup.2 -4-N-R.sup.3 -N-R.sup.4 -aminophenyl)carbonyl-X-benzoic acid with the corresponding 1-R-2-R.sup.1 -5/6-Y-indole. The furopyridines are prepared by the interaction of the corresponding 2/3-(1-R-2-R.sup.1 -5/6-Y-indol-3-yl)carbonylpyridine-3/2-carboxylic acid with the corresponding 3-R.sup.2 -N-R.sup.3 -N-R.sup.4 -aniline. The novel 1-R-2-R.sup.1 -5/6-Y-indol-3-yl)carbonyl-X-benzoic acids and 1-R-2-R.sup.1 -5/6-Y-indoles are useful as intermediates to the appropriate phthalides and furopyridinones.

  3-(1-R-2-R.sup.1 -5/6-Y-吲哚-3-基)-3-(2-R.sup.2-4-N-R.sup.3-N-R.sup.4-氨基苯基)-X-邻苯二甲酸酐，7-(1-R-2-R.sup.1 -5/6-Y-吲哚-3-基)-7-(2-R.sup.2-4-N-R.sup.3-N-R.sup.4-氨基苯基)呋喃[3,4b]-吡啶-5(7H)-酮和5-(1-R-2-R.sup.1 -5/6-Y-吲哚-3-基)-5-(2-R.sup.2-4-N-R.sup.3-N-R.sup.4-氨基苯基)呋喃[3,4b]-吡啶-7(5H)-酮可用于转移成像系统、压敏无碳复写系统和热响应标记系统中的色彩形成剂。邻苯二甲酸酐是通过相应的2-(1-R-2-R.sup.1 -5/6-Y-吲哚-3-基)羰基-X-苯甲酸与相应的3-R.sup.2-N-R.sup.3-N-R.sup.4-苯胺或相应的2-(2-R.sup.2-4-N-R.sup.3-N-R.sup.4-氨基苯基)羰基-X-苯甲酸与相应的1-R-2-R.sup.1 -5/6-Y-吲哚反应制备的。呋喃吡啶是通过相应的2/3-(1-R-2-R.sup.1 -5/6-Y-吲哚-3-基)羰基吡啶-3/2-羧酸与相应的3-R.sup.2-N-R.sup.3-N-R.sup.4-苯胺反应制备的。新颖的1-R-2-R.sup.1 -5/6-Y-吲哚-3-基)羰基-X-苯甲酸和1-R-2-R.sup.1 -5/6-Y-吲哚可用作制备相应邻苯二甲酸酐和呋喃吡啶酮的中间体。
• Indole-phthalide derivatives
  申请人：Hilton Davis Chemical Co.

  公开号：US04736027A1

  公开（公告）日：1988-04-05

  3-(1-R-2-R.sup.1 -5/6-Y-indol-3-yl)-3-(2-R.sup.2 -4-N-R.sup.3 -N-R.sup.4 -aminophenyl)-X-phthalides, 7-(1-R-2-R.sup.1 -5/6-Y-indol-3-yl)-7-(2-R.sup.2 -4-N-R.sup.3 -N-R.sup.4 -aminophenyl)furo[3,4b]-pyridine-5-(7H)-ones and 5-(1-R-2-R.sup.1 -5/6-Y-indol-3-yl)-5-(2-R.sup.2 -4-N-R.sup.3 -N-R.sup.4 -aminophenyl)furo[3,4b]-pyridine-7(5H)-ones are useful as color formers in transfer imaging systems, pressure-sensitive carbonless duplicating systems and thermal-responsive marking systems. The phthalides are prepared by the interaction of the corresponding 2-(1-R-2-R.sup.1 -5/6-Y-indol-3-yl)carbonyl-X-benzoic acid with the corresponding 3-R.sup.2 -N-R.sup.3 -N-R.sup.4 -aniline or the interaction of the corresponding 2-(2-R.sup.2 -4-N-R.sup.3 -N-R.sup.4 -aminophenyl)carbonyl-X-benzoic acid with the corresponding 1-R-2-R.sup.1 -5/6-Y-indole. The furopyridines are prepared by the interaction of the corresponding 2/3-(1-R-2-R.sup.1 -5/6-Y-indol-3-yl)carbonylpyridine-3/2-carboxylic acid with the corresponding 3-R.sup.2 -N-R.sup.3 -N-R.sup.4 -aniline. The novel 1-R-2-R.sup.1 -5/6-Y-indol-3-yl)carbonyl-X-benzoic acids and 1-R-2-R.sup.1 -5/6-Y-indoles are useful as intermediates to the appropriate phthalides and furopyridinones.

  3-(1-R-2-R.sup.1 -5/6-Y-indol-3-yl)-3-(2-R.sup.2 -4-N-R.sup.3 -N-R.sup.4 -aminophenyl)-X-邻苯二酸酐，7-(1-R-2-R.sup.1 -5/6-Y-indol-3-yl)-7-(2-R.sup.2 -4-N-R.sup.3 -N-R.sup.4 -aminophenyl)furo[3,4b]-吡啶-5-(7H)-酮和5-(1-R-2-R.sup.1 -5/6-Y-indol-3-yl)-5-(2-R.sup.2 -4-N-R.sup.3 -N-R.sup.4 -aminophenyl)furo[3,4b]-吡啶-7(5H)-酮在转移成像系统、压敏无碳复写系统和热响应标记系统中作为色彩形成剂使用。邻苯二酸酐通过相应的2-(1-R-2-R.sup.1 -5/6-Y-吲哚-3-基)羰基-X-苯甲酸与相应的3-R.sup.2 -N-R.sup.3 -N-R.sup.4 -苯胺或相应的2-(2-R.sup.2 -4-N-R.sup.3 -N-R.sup.4 -氨基苯基)羰基-X-苯甲酸与相应的1-R-2-R.sup.1 -5/6-Y-吲哚相互作用制备。呋喃吡啶通过相应的2/3-(1-R-2-R.sup.1 -5/6-Y-吲哚-3-基)羰基吡啶-3/2-羧酸与相应的3-R.sup.2 -N-R.sup.3 -N-R.sup.4 -苯胺相互作用制备。新型1-R-2-R.sup.1 -5/6-Y-吲哚-3-基)羰基-X-苯甲酸和1-R-2-R.sup.1 -5/6-Y-吲哚可用作适当的邻苯二酸酐和呋喃吡啶酮的中间体。
• Novel substituted phthalides and furopyridinones, preparation thereof and use thereof as color formers
  申请人：HILTON-DAVIS CHEMICAL CO.

  公开号：EP0206114A2

  公开（公告）日：1986-12-30

  3-(1-R-2-R1-5/6-Y-indol-3-yl)-3-(2-R2-4-N-R3-N-R4-aminophenyl)-X-phthalides,7-(1-R-2-R1-5/6-Y-indol-3-yl)-7-(2-R2-4-N-R3-N-R4-aminophenyl)furo[3,4b]-pyridine-5(7H)-ones and 5-(1-R-2-R1-5/6-Y-indol-3-yl)-5-(2-R2-4-N-R3-N-R4-aminophenyl)furo[3,4b]-pyridine-7(5H)-ones are useful as color formers in transfer imaging systems, pressure-sensitive carbonless duplicating systems and thermal-responsive marking systems. The phthalides are prepared by the interaction of the corresponding 2-(1-R-2-R1-5/6-Y-indol-3-yl)carbonyl-X-benzoic acid with the corresponding 3-R2-N-R3-N-R4-aniline or the interaction of the corresponding 2-(2-R2-4-N-R3-N-R4-aminophenyl)carbonyl-X-benzoic acid with the corresponding 1-R-2-R1-5/6-Y-indole. The furopyridines are prepared by the interaction of the corresponding 2/3-(1-R-2-R1-5/6-Y-indol-3-yl)carbonylpyridine-3/2-carboxylic acid with the corresponding 3-R2-N-R3-N-R4-aniline. The novel 1-R-2-R1-5/6-Y-indol-3-yl)carbonyl-X-benzoic acids and 1-R-2-R1-5/6-Y-indoles are useful as intermediates to the appropriate phthalides and furopyridinones.

  3-(1-R-2-R1-5/6-Y-indol-3-yl)-3-(2-R2-4-N-R3-N-R4-aminophenyl)-X-phthalides,7-(1-R-2-R1-5/6-Y-indol-3-yl)-7-(2-R2-4-N-R3-N-R4-aminophenyl)furo[3,4b]-pyridine-5(7H)-ones and 5-(1-R-2-R1-5/6-Y-indol-3-yl)-5-(2-R2-4-N-R3-N-R4-aminophenyl)furo[3,4b]-吡啶-7(5H)-酮可用作转印成像系统、压敏无碳复写系统和热敏打标系统中的显色剂。邻苯二甲酸盐是通过相应的 2-(1-R-2-R1-5/6-Y-吲哚-3-基)羰基-X-苯甲酸与相应的 3-R2-N-R3-N-R4-苯胺的相互作用或相应的 2-(2-R2-4-N-R3-N-R4-氨基苯基)羰基-X-苯甲酸与相应的 1-R-2-R1-5/6-Y-吲哚的相互作用制备的。相应的 2/3-(1-R-2-R1-5/6-Y-吲哚-3-基)羰基吡啶-3/2-羧酸与相应的 3-R2-N-R3-N-R4-苯胺相互作用，制备出呋喃吡啶。新型 1-R-2-R1-5/6-Y-吲哚-3-基)羰基-X-苯甲酸和 1-R-2-R1-5/6-Y-吲哚可用作适当邻苯二甲酸盐和呋喃吡啶酮的中间体。
• HUNG, WILLIAM M.;BLACK, ANGELIQUI M.
  作者：HUNG, WILLIAM M.、BLACK, ANGELIQUI M.

  DOI：——

  日期：——
• SYNTHESIS OF CATECHOL FROM BIOMASS-DERIVED CARBON SOURCES
  申请人：Purdue Research Foundation

  公开号：EP0722488B1

  公开（公告）日：2004-06-30