(+)-3-(1-benzyl-trans-3,4-dimethyl-piperidin-4-yl)-benzonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (+)-3-(1-benzyl-trans-3,4-dimethyl-piperidin-4-yl)-benzonitrile
• 英文别名: 1-Benzyl-4-(3-cyanophenyl)-3,4-dimethylpiperidine；3-(1-benzyl-3,4-dimethylpiperidin-4-yl)benzonitrile
• 化学式: C₂₁H₂₄N₂
• 分子量: 304.435
• InChiKey: QAUHHVDVCNDKNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (+)-3-(1-benzyl-trans-3,4-dimethyl-piperidin-4-yl)-benzonitrile 在 palladium on charcoal 正丁基锂 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 、 新庚酰氯 为溶剂， 生成 3,4-dimethyl-4-(3-(1H-1,2,3-triazol-4-yl)phenyl)piperidine
  参考文献：
  名称：

  4-arylpiperidine derivatives for the treatment of pruritus

  摘要：

  公开号：

  EP1072601B1
• 作为产物：
  描述：

  4-(3-hydroxyphenyl)-trans-3,4-dimethylpiperidine 在 palladium diacetate 碳酸氢钠 、 三乙胺 作用下， 以 sodium hydroxide 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 (+)-3-(1-benzyl-trans-3,4-dimethyl-piperidin-4-yl)-benzonitrile
  参考文献：
  名称：

  4-arylpiperidine derivatives for the treatment of pruritus

  摘要：

  公开号：

  EP1072601B1

文献信息

• New 4-arylpiperidine derivatives for the treatment of pruritus
  申请人：——

  公开号：US20030004340A1

  公开（公告）日：2003-01-02

  There is provided a compound of formula I, 1 wherein Het 1 , R 1 , R 2 , R 3 , X and n have meanings given in the description, which are useful in the prophylaxis and in the treatment of diseases mediated by opiate receptors, such as pruritus.

  提供了一种公式I的化合物，其中Het1、R1、R2、R3、X和n具有说明书中给出的含义，它们在通过阿片受体介导的疾病的预防和治疗中是有用的，例如瘙痒。
• 4-Phenyl-piperidine compounds and their use as modulators of opioid receptors
  申请人：Pfizer Inc

  公开号：US20040204453A1

  公开（公告）日：2004-10-14

  The subject invention relates to 4-phenyl-piperidine derivatives, pharmaceutical compositions comprising such derivatives and methods of using such derivatives to treat disease states, disorders and conditions mediated by an opioid receptor. The subject also particularly relates to using such derivatives to treat certain disease states, disorders and conditions, for example irritable bowel syndrome, drug addiction or dependency, including alcohol addiction, depression, anxiety, schizophrenia, anxiety, schizophrenia and eating disorders, among numerous other disease states, disorders and conditions as more fully described herein.

  本发明涉及4-苯基哌啶衍生物，包括这些衍生物的药物组合物以及使用这些衍生物治疗由阿片受体介导的疾病状态、紊乱和情况的方法。该发明还特别涉及使用这些衍生物治疗某些疾病状态、紊乱和情况，例如肠易激综合征、药物成瘾或依赖，包括酒精成瘾、抑郁症、焦虑症、精神分裂症、焦虑症、精神分裂症和进食障碍等多种其他疾病状态、紊乱和情况，如本文所述。
• EP1615643A1
  申请人：——

  公开号：EP1615643A1

  公开（公告）日：2006-01-18
• US6750231B2
  申请人：——

  公开号：US6750231B2

  公开（公告）日：2004-06-15
• [EN] 4-PHENYL-PIPERIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF OPIOID RECEPTORS<br/>[FR] COMPOSES DE 4-PHENYLE-PIPERIDINE ET LEUR UTILISATION COMME MODULATEURS DES RECEPTEURS OPIOIDES
  申请人：PFIZER PROD INC

  公开号：WO2004089370A1

  公开（公告）日：2004-10-21

  The subject invention relates to 4-phenyl-piperidine derivatives of formula (I), pharmaceutical compositions comprising such derivatives and methods of using such derivatives to treat disease states, disorders and conditions mediated by an opioid receptor. The subject also particularly relates to using such derivatives to treat certain disease states, disorders and conditions, for example irritable bowel syndrome, drug addiction or dependency, including alcohol addiction, depression, anxiety, schizophrenia, anxiety, schizophrenia and eating disorders, among numerous other disease states, disorders and conditions as more fully described herein.