3,4,5,6-tetrahydro-2-isopropyl-5-methyl-2,6-methano-2H-1-benzoxocin-9-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3,4,5,6-tetrahydro-2-isopropyl-5-methyl-2,6-methano-2H-1-benzoxocin-9-ol
• 英文别名: 12-Methyl-9-propan-2-yl-8-oxatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-5-ol
• 化学式: C₁₆H₂₂O₂
• 分子量: 246.349
• InChiKey: LUHLKLOHISHATK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (1R,5R)-(+)-β-pinene 、 间苯二酚 在 Hβ-zeolite 作用下， 以 二氯甲烷 为溶剂， 以15%的产率得到3,4,5,6-tetrahydro-5-isopropyl-2-methyl-2,6-methano-2H-1-benzoxocin-9-ol
  参考文献：
  名称：

  (-)--蒎烯与酚类在有组织介质中的反应合成光学活性三环醚

  摘要：

  The reactions of (-)-beta-pinene (1) with some methyl- and hydroxy-substituted phenols on Hbeta-zeolite yield optically active products - tricyclic terpenyl phenyl ethers - in contrast to reactions in homogeneous media, which occur with loss of optical activity. The formation of these products is promoted by the presence of meta-substituents in the phenol molecule.

  DOI：

  10.1002/1522-2675(200208)85:8<2358::aid-hlca2358>3.0.co;2-r

文献信息

• Synthesis of Optically Active Tricyclic Ethers by Reactions of (−)--Pinene with Phenols in Organized Media
  作者：Vladislav V. Fomenko、Dina V. Korchagina、Nariman F. Salakhutdinov、Vladimir A. Barkhash

  DOI：10.1002/1522-2675(200208)85:8<2358::aid-hlca2358>3.0.co;2-r

  日期：2002.8

  The reactions of (-)-beta-pinene (1) with some methyl- and hydroxy-substituted phenols on Hbeta-zeolite yield optically active products - tricyclic terpenyl phenyl ethers - in contrast to reactions in homogeneous media, which occur with loss of optical activity. The formation of these products is promoted by the presence of meta-substituents in the phenol molecule.