乙酰氨基荧光素 | 82779-14-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 乙酰氨基荧光素
• 中文别名: 2H-吖庚英-7-胺,4-乙基-3,4,5,6-四氢-
• 英文名称: 5-acetamidofluorescein
• 英文别名: N-(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-yl)acetamide
• CAS: 82779-14-4
• 化学式: C₂₂H₁₅NO₆
• 分子量: 389.364
• InChiKey: FFFNOSBBXSHTRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  29
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  乙酰氨基荧光素 、 2-(2-硝基苯基)-2-甲基乙基氯甲酸酯 在 吡啶 作用下， 以40.3%的产率得到
  参考文献：
  名称：

  A photo-responsive chemical modulation of m⁶A RNA demethylase FTO

  摘要：

  设计、合成和评价一种光响应性和选择性FTO抑制剂。

  DOI：

  10.1039/d1cc04091j
• 作为产物：
  描述：

  5-氨基荧光素 在 sodium hydroxide 作用下， 以 吡啶 为溶剂， 反应 1.03h， 生成 乙酰氨基荧光素
  参考文献：
  名称：

  Preparation and properties of fluorescent glycosamino-glycuronans labeled with 5-aminofluorescein

  摘要：

  The uronic acid residues of all known glycosaminoglycuronans reacted with 5-aminofluorescein to yield fluorescent glycosaminoglycuronan derivatives, which showed fluorescence characteristics identical to those of fluorescein or 5-acetamidofluorescein. The fluorescent products could be purified by chromatography on Octyl-Sepharose; three preparations of labeled chondroitin 6-sulfate having different degrees of substitution, and a labeled heparin were obtained. Fluorescent hyaluronic acid containing labeled and unlabeled molecules was digested with testicular hyaluronidase to give fluorescent oligosaccharides. Fluorescent chondroitin 6-sulfate was treated with chondroitinase AC to give a nonfluorescent disaccharide and minor proportion of fluorescent octasaccharide. Fluorescent heparin retained its anticoagulant activity, which was similar to that of the starting heparin; its half-life in circulating rabbit blood was 36 min (by fluorometry) and 45 min (by clotting-time assay).

  DOI：

  10.1016/s0008-6215(00)81855-8

文献信息

• [EN] HYDROGELS WITH BIODEGRADABLE CROSSLINKING<br/>[FR] HYDROGELS À RÉTICULATION BIODÉGRADABLE
  申请人：PROLYNX LLC

  公开号：WO2013036847A1

  公开（公告）日：2013-03-14

  Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals. This invention provides hydrogels that degrade to smaller, soluble components in a non-enzymatic process upon exposure to physiological conditions and to methods to prepare them. The hydrogels are prepared from crosslinking agents that undergo elimination reactions under physiological conditions, thus cleaving the crosslinking agent from the backbone of the hydrogel. The invention also relates to the crosslinking agents themselves and intermediates in forming the hydro gels of the invention. The biodegradable hydro gels prepared according to the methods of the invention may be of use in diverse fields, including biomedical engineering, absorbent materials, and as carriers for drug delivery.

  描述了在适当的pH和温度条件下通过交联化合物裂解的水凝胶。这些水凝胶可用于传递各种药剂，如药物。该发明提供了在暴露于生理条件下会非酶催化降解为较小可溶性组分的水凝胶，以及制备它们的方法。这些水凝胶是由在生理条件下发生消除反应的交联剂制备而成，从而将交联剂从水凝胶的骨架中裂解出来。该发明还涉及交联剂本身以及形成该发明的水凝胶的中间体。根据该发明的方法制备的可生物降解水凝胶可用于各种领域，包括生物医学工程、吸收材料以及作为药物传递的载体。
• HYDROGELS WITH BIODEGRADABLE CROSSLINKING
  申请人：ProLynx LLC

  公开号：US20170312368A1

  公开（公告）日：2017-11-02

  Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.

  描述了在适当的pH和温度条件下，由于交联化合物通过消除反应而降解的水凝胶。这些水凝胶可以用于输送各种药剂，如药物。
• CHEMOSENSOR AND A METHOD OF DETECTING PALLADIUM IONS
  申请人：King Fahd University of Petroleum and Minerals

  公开号：US20200392148A1

  公开（公告）日：2020-12-17

  A palladium selective chemosensor based on a fluorescein-allyloxy benzene scaffold and a method of detecting palladium ions in a fluid sample with the chemosensor, whereby the fluid sample is contacted with a solution that includes water and the chemosensor to form a mixture. An ultraviolet visible absorption profile and/or a fluorescence emission profile of the mixture is measured to determine a presence or absence of palladium ions in the fluid sample, wherein the chemosensor has an ultraviolet visible absorption peak at 315 to 325 nm and a fluorescence emissions peak at 380 to 400 nm in the solution, and wherein a bathochromic shift in the ultraviolet visible absorption peak to 338 to 342 nm in the mixture and/or a bathochromic shift in the fluorescence emissions peak to 530 to 550 nm in the mixture indicates the presence of palladium ions in the fluid sample.

  一种基于荧光素-烯丙氧基苯基骨架的钯选择性化学传感器，以及使用该化学传感器检测液体样品中钯离子的方法，其中将液体样品与包括水和化学传感器的溶液接触以形成混合物。测量混合物的紫外可见吸收谱和/或荧光发射谱以确定液体样品中钯离子的存在或不存在，其中化学传感器在溶液中具有315至325 nm的紫外可见吸收峰和380至400 nm的荧光发射峰，在混合物中紫外可见吸收峰向338至342 nm的巴氏红移和/或荧光发射峰向530至550 nm的巴氏红移表明液体样品中存在钯离子。
• Hydrogels with biodegradable crosslinking
  申请人：ProLynx LLC

  公开号：US10398779B2

  公开（公告）日：2019-09-03

  Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.

  本文介绍了在适当的 pH 值和温度条件下，交联化合物通过消除反应裂解而降解的水凝胶。这种水凝胶可用于输送各种药剂，如药物。
• Chemosensor and a method of detecting palladium ions
  申请人：King Fahd University of Petroleum and Minerals

  公开号：US11124522B2

  公开（公告）日：2021-09-21

  A palladium selective chemosensor based on a fluorescein-allyloxy benzene scaffold and a method of detecting palladium ions in a fluid sample with the chemosensor, whereby the fluid sample is contacted with a solution that includes water and the chemosensor to form a mixture. An ultraviolet visible absorption profile and/or a fluorescence emission profile of the mixture is measured to determine a presence or absence of palladium ions in the fluid sample, wherein the chemosensor has an ultraviolet visible absorption peak at 315 to 325 nm and a fluorescence emissions peak at 380 to 400 nm in the solution, and wherein a bathochromic shift in the ultraviolet visible absorption peak to 338 to 342 nm in the mixture and/or a bathochromic shift in the fluorescence emissions peak to 530 to 550 nm in the mixture indicates the presence of palladium ions in the fluid sample.

  一种基于荧光素-烯丙氧基苯支架的钯选择性化学传感器和一种用该化学传感器检测流体样品中钯离子的方法，其中流体样品与包括水和化学传感器的溶液接触以形成混合物。测量混合物的紫外可见吸收曲线和/或荧光发射曲线，以确定流体样品中是否存在钯离子，其中化学传感器在溶液中的紫外可见吸收峰值为 315 至 325 纳米，荧光发射峰值为 380 至 400 纳米、其中，混合物中紫外可见吸收峰向 338 至 342 纳米的浴色偏移和/或混合物中荧光发射峰向 530 至 550 纳米的浴色偏移表明流体样品中存在钯离子。