7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)-butoxy)-3,4-dihydro-2(1H)-carbostyril citrate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)-butoxy)-3,4-dihydro-2(1H)-carbostyril citrate
• 英文别名: aripiprazole citrate；7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one;2-hydroxypropane-1,2,3-tricarboxylic acid
• 化学式: C₆H₈O₇*C₂₃H₂₇Cl₂N₃O₂
• 分子量: 640.518
• InChiKey: MSVHVSZSQKJRMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.61
• 重原子数：
  43
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  177
• 氢给体数：
  5
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  柠檬酸 、 阿立哌唑 以 乙酸乙酯 为溶剂， 反应 2.0h， 以94%的产率得到7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)-butoxy)-3,4-dihydro-2(1H)-carbostyril citrate
  参考文献：
  名称：

  Crystalline aripiprazole salts and processes for preparation and purification thereof

  摘要：

  提供了阿立哌唑的新型结晶羧酸盐，使用这种盐的方法以及生产这种盐的过程。

  公开号：

  US20060223820A1

文献信息

• [EN] PROCESS FOR THE PREPARATION OF POLYMORPHS, SOLVATES OF ARIPIPRAZOLE USING ARIPIPRAZOLE ACID SALTS<br/>[FR] PROCEDE DESTINE A LA PREPARATION DE POLYMORPHES ET DE SOLVATES D'ARIPIPRAZOLE A PARTIR DE SELS D'ACIDE D'ARIPIPRAZOLE
  申请人：MATRIX LAB LTD

  公开号：WO2006030446A1

  公开（公告）日：2006-03-23

  The present invention relates to Aripiprazole, a useful agent for antipsychotic. The present invention also provides new acid addition salts of Aripiprazole and process for the preparation of polymorphs and solvates of Aripiprazole using Aripiprazole acid salts, their interconversion and the process for preparation of Aripiprazole acid salts.

  本发明涉及阿立哌唑，它是一种有用的抗精神病药物。本发明还提供了阿立哌唑的新酸加盐和使用阿立哌唑酸盐制备阿立哌唑多晶形和溶剂化物的过程，它们之间的相互转化以及制备阿立哌唑酸盐的过程。
• Process for the preparation of polymorphs, solvates of aripiprazole using aripirazole acid salts
  申请人：Satyanarayana Chava

  公开号：US20090198059A1

  公开（公告）日：2009-08-06

  The present invention relates to Aripiprazole, a useful agent for antipsychotic. The present invention also provides new acid addition salts of Aripiprazole and process for the preparation of polymorphs and solvates of Aripiprazole using Aripiprazole acid salts, their interconversion and the process for preparation of Aripiprazole acid salts.

  本发明涉及阿立哌唑，一种有用的抗精神病药物。本发明还提供了阿立哌唑的新酸盐添加物和使用阿立哌唑酸盐的制备多晶形和溶剂化物的过程，它们之间的相互转化以及制备阿立哌唑酸盐的过程。
• New crystalline aripiprazole salts and processes for preparation and purification thereof
  申请人：CHEMAGIS LTD.

  公开号：EP1837331A2

  公开（公告）日：2007-09-26

  Provided are novel crystalline carboxylic acid salts of aripiprazole [7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)-butoxy)-3,4-dihydro-2(1H)-quinolinone], methods of using such salts, and processes for producing such salts.

  本文提供了阿立哌唑[7-(4-(4-(2,3-二氯苯基)-1-哌嗪基)-丁氧基)-3,4-二氢-2(1H)-喹啉酮]的新型结晶羧酸盐、使用这种盐的方法以及生产这种盐的工艺。
• PROCESS FOR THE PREPARATION OF POLYMORPHS, SOLVATES OF ARIPIPRAZOLE USING ARIPIPRAZOLE ACID SALTS
  申请人：Matrix Laboratories Ltd

  公开号：EP1797039A1

  公开（公告）日：2007-06-20
• [EN] ARIPIPRAZOLE-BENTONITE-AEA HYBRID, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND METHOD FOR PREPARING THE SAME<br/>[FR] HYBRIDE ARIPIPRAZOLE-BENTONITE-AEA, COMPOSITION PHARMACEUTIQUE LE CONTENANT ET SON PROCÉDÉ DE PRÉPARATION
  申请人：DAE WOONG PHARMA

  公开号：WO2011031100A2

  公开（公告）日：2011-03-17

  The present invention relates to an aripiprazole-bentonite-AEA hybrid, a pharmaceutical composition containing the same and a method for preparing the same. The aripiprazole-bentonite-AEA hybrid according to the present invention is very useful as an active ingredient of a pharmaceutical composition for treating psychiatric illness including schizophrenia and bipolar disorder because of its bitter-taste-blocking effect and improved body absorption rate with high solubility.