polygonflavanol A

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: polygonflavanol A
• 英文别名: (2S,3R,4S,5S,6R)-2-[2-[(3S,4R,5S,6R,7R)-7-(3,4-dihydroxyphenyl)-6,11-dihydroxy-3-(4-hydroxyphenyl)-2,8-dioxatricyclo[7.3.1.05,13]trideca-1(13),9,11-trien-4-yl]-4,6-dihydroxyphenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
• 化学式: C₃₅H₃₄O₁₅
• 分子量: 694.646
• InChiKey: YOOCVTIYZNOVKI-MTEGXVNVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  50
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  259
• 氢给体数：
  11
• 氢受体数：
  15

反应信息

• 作为反应物：
  描述：

  polygonflavanol A 在 盐酸 、 水 作用下， 以 甲醇 为溶剂， 反应 4.0h， 生成 D-葡萄糖
  参考文献：
  名称：

  Polygonflavanol A, a novel flavonostilbene glycoside from the roots of Polygonum multiflorum

  摘要：

  Polygonflavanol A (1), a novel flavonostilbene glycoside with an unusual coupling pattern, together with five known stilbene glycosides (2-6), was isolated from the roots of Polygonum multiflorum. The structures were elucidated on the basis of extensive spectroscopic analysis and chemical evidence. The absolute configuration of 1 was further determined by CD analysis. Most of the compounds could inhibit nitric oxide (NO) secretion of RAW264.7 cells in respond to lipopolysaccharide (LPS) in a dose dependent manner. Among them, compound 2 displayed the highest inhibitory activity. (c) 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.phytol.2012.08.007

文献信息

• Polygonflavanol A, a novel flavonostilbene glycoside from the roots of Polygonum multiflorum
  作者：Li-Li Chen、Xiao-Jun Huang、Man-Mei Li、Guo-Min Ou、Bing-Xin Zhao、Min-Feng Chen、Qing-Wen Zhang、Ying Wang、Wen-Cai Ye

  DOI：10.1016/j.phytol.2012.08.007

  日期：2012.12

  Polygonflavanol A (1), a novel flavonostilbene glycoside with an unusual coupling pattern, together with five known stilbene glycosides (2-6), was isolated from the roots of Polygonum multiflorum. The structures were elucidated on the basis of extensive spectroscopic analysis and chemical evidence. The absolute configuration of 1 was further determined by CD analysis. Most of the compounds could inhibit nitric oxide (NO) secretion of RAW264.7 cells in respond to lipopolysaccharide (LPS) in a dose dependent manner. Among them, compound 2 displayed the highest inhibitory activity. (c) 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.