(1,10-phenanthroline)copper(II) nitrate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: (1,10-phenanthroline)copper(II) nitrate
• 英文别名: (1,10-phenathroline)copper(II)(NO3)2；Cu(phenanthroline)(NO3)2；phen；[Cu(1,10-phenanthroline)(NO₃)₂]_n；Cu(1,10‐phenanthroline)(NO₃)₂；[Cu(1,10-phenanthroline)](NO₃)₂
• 化学式: C₁₂H₈N₂*Cu*2NO₃
• 分子量: 367.765
• InChiKey: WSGSQGXZPJYNDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.54
• 重原子数：
  19.0
• 可旋转键数：
  0.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91.98
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  二吡啶并[3,2-a:2',3'-c]吩嗪 、 (1,10-phenanthroline)copper(II) nitrate 以 乙醇 为溶剂， 反应 12.0h， 以41%的产率得到[Cu(DPPZ)(Phen)](NO₃)₂
  参考文献：
  名称：

  铜菲氧化化学核酸酶

  摘要：

  这里，我们报告了一系列的合成和分离双-螯合物的Cu 2+菲咯啉吩嗪[铜（DPQ）（phen）的]的阳离子络合物2+，[Cu（上DPPZ）（phen）的] 2+和[铜（DPPN）（Phen）] 2+（其中Phen = 1,10-菲咯啉，DPQ =二吡咯并喹喔啉，DPPZ =二吡咯吩嗪，DPPN =苯并[ i ]二吡啶并吩嗪）。相对于经过充分研究的化学核酸酶[Cu（Phen）2 ] 2+（bis-Phen），这些化合物具有增强的DNA识别，其DPQ和DPPZ试剂的小牛胸腺DNA结合常数（〜10 7 M（bp）- 1）是目前已知的最高Cu 2+菲化合物。复杂的DNA结合遵循DPQ≈DPPZ> DPPN> bis-Phen，在poly [d（AT）2 ]和poly [d（GC）2 ]上进行荧光猝灭和热熔实验，支持在小槽和大槽处的插入。然而，吩嗪复合物在富含胞嘧啶-磷酸-鸟嘌呤的DNA上显示出增强的

  DOI：

  10.1021/ic500914j
• 作为产物：
  描述：

  [Cu(1,10-phenanthroline)2*(H2O)]*(NO3)2 以 neat (no solvent) 为溶剂， 生成 (1,10-phenanthroline)copper(II) nitrate
  参考文献：
  名称：

  Synthesis and crystal structure of copper(II) 2, 2, 6, 6-tetramethylheptan-3, 5-dionate adduct with o-phenanthroline

  摘要：

  The X-ray crystal structure of Cu(thd)(2) . Phen, which is the first adduct of Cu(thd)(2) reported to be stable in the vapor phase, was determined. A cis-octahedral arrangement of chelate ligands around copper is of low symmetry due to Jahn-Teller distortion and the rigidity of the ligands. Peculiarities of the Cu(thd)(2) . Phen synthesis are discussed. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0277-5387(96)00476-7
• 作为试剂：
  描述：

  环戊二烯 、 (E)-3-phenyl-1-(pyridin-2-yl)-2-propen-1-one 在 (1,10-phenanthroline)copper(II) nitrate 、 sodium chloride 作用下， 以 乙腈 为溶剂， 反应 48.0h， 以84% ee的产率得到
  参考文献：
  名称：

  人工金属酶的体内组装及其在全细胞生物催化中的应用**

  摘要：

  我们报告了基于乳球菌多药耐药调节剂（LmrR）和外源铜（II）-菲咯啉复合物在大肠杆菌细胞质中的人工金属酶（ArMs）的超分子组装。催化、细胞分级和抑制剂实验相结合，辅以细胞内固态核磁共振波谱，证实了细胞内组装。含有ArM的全细胞在吲哚的对映选择性弗里德尔-克来福特烷基化以及氮杂查耳酮与环戊二烯的狄尔斯-阿尔德反应的催化中具有活性。定向进化导致这两种反应分别产生两种不同的改进突变体：LmrR_A92E_M8D和LmrR_A92E_V15A。全细胞 ArM 系统不需要对微生物宿主、蛋白质支架或辅因子进行工程改造即可实现 ArM 组装和催化。我们认为这是将非生物催化与生物合成相结合以产生混合代谢的关键一步。

  DOI：

  10.1002/anie.202014771

文献信息

• Intramolecular Luminescence Quenching in Amino Acid Bridged Ruthenium(II)-Copper(II) Complexes with Negligible Ground-State Coupling
  作者：Bernd Geißer、Ralf Alsfasser

  DOI：10.1002/(sici)1099-0682(199807)1998:7<957::aid-ejic957>3.0.co;2-6

  日期：1998.7

  appreciable ground-state coupling between ruthenium(II) and copper(II). However, the luminescence of 1b–4b is significantly quenched compared to that of the parent compounds 1a–4a. Quenching was found to proceed only intramolecularly and to be most efficient in 1b with the shortest alkyl spacer. Equilibrium constants for the formation of 1b–4b were determined from luminescence titrations of the respective ruthenium-substituted

  一系列异双金属配合物 [Ru(bipy)2}m-AACu(phen)(H2O)}](PF6)3 (m-AA = Nω-(4-carbonyl-4′-methyl-2,2 '-联吡啶基)-L-α,ω-二氨基酸；二氨基酸 (AA): 1b, L-2,3-二氨基丙酸; 2b, L-2,4-二氨基丁酸; 3b, L-鸟氨酸, 4b, L-赖氨酸）已从 2,2'-联吡啶钌 (II) 取代的氨基酸 [Ru(bipy)2}m-AA-αN-tBoc]2+ (αN-tBoc-1a– 4a，αN-tBoc = Nα-叔丁氧基羰基）。1b-4b 中的金属中心由绝缘的烷基链桥接。因此，光谱和电化学研究证实了钌 (II) 和铜 (II) 之间不存在任何明显的基态耦合。然而，与母体化合物 1a-4a 的发光相比，1b-4b 的发光显着淬灭。发现淬火仅在分子内进行，并且在具有最短烷基间隔基的 1b 中最有效。1b-4b
• Synthesis, Characterization and DNA Cleavage Activity of the Coordination Polymer {[Cu(phen)(azpy)(NO3)(H2O)]·(NO3)}n
  作者：Mukta B. Baraskar、Vitthal A. Kawade、Satish S. Bhat、Ray J. Butcher、Manali Mohite、Nikita Deshmukh、Anupa A. Kumbhar

  DOI：10.1007/s10870-022-00923-7

  日期：2022.12

  ion–dipole interactions. The N4O2 coordination sphere of copper(II) involves two nitrogens from different azpy’s, two nitrogens from phen, one oxygen from water and one oxygen from a nitrate anion. Thermal studies reveal that the coordination polymer (1) is thermally stable upto 166 °C. Compound (1) cleaves plasmid pBR322 DNA by an oxidative mechanism involving hydroxyl and superoxide radicals at low concentrations

  一维[Cu(phen)(azpy)(NO 3 )(H 2 O)]·(NO 3 )} n配位聚合物( 1 )，其中azpy = 4,4'-偶氮吡啶和phen = 1， 10-菲咯啉已合成并通过元素分析、FT-IR 和紫外-可见光谱、热分析和单晶 X 射线衍射 (SCXRD) 进行了表征。SCXRD显示化合物( 1 )通过桥连azpy间隔物形成Z字形一维(1D)配位聚合物。一维聚合物链通过氢键、π-π堆积和离子-偶极相互作用自组装形成三维网络。N 4 O 2铜 (II) 的配位层涉及来自不同 azpy 的两个氮，来自 phen 的两个氮，来自水的一个氧和一个来自硝酸根阴离子的氧。热学研究表明，配位聚合物 ( 1 ) 在高达 166 °C 的温度下是热稳定的。化合物( 1 )通过涉及低浓度羟基和超氧自由基的氧化机制切割质粒pBR322 DNA。 图形概要 一维[Cu(phen)(azpy)(NO
• Liposomal Binuclear Ir(III)–Cu(II) Coordination Compounds with Phosphino-Fluoroquinolone Conjugates for Human Prostate Carcinoma Treatment
  作者：Urszula K. Komarnicka、Sandra Kozieł、Barbara Pucelik、Agata Barzowska、Miłosz Siczek、Magdalena Malik、Daria Wojtala、Alessandro Niorettini、Agnieszka Kyzioł、Victor Sebastian、Pavel Kopel、Stefano Caramori、Alina Bieńko

  DOI：10.1021/acs.inorgchem.2c03015

  日期：2022.12.5

  three additional sites occupied by two chloride and phosphine ligands, while CuII ions in complexes 1 and 2 form a distorted square-pyramidal coordination geometry, and in complex 3, the coordination geometry around CuII ions is a distorted octahedron. Interestingly, the crystal structure of [Ir(η5-Cp*)Cl2Plfx-Cu(phen)] features the one-dimensional (1D) metal–organic polymer. Liposomes loaded with redox-active

  新型异核 Ir III –Cu II配位化合物 ([Ir(η 5 -Cp*)Cl 2 Pcfx-Cu(phen)](NO 3 )·1.75(CH 3 OH)·0.75(H 2 O) ( 1 ), [Ir(η 5 -Cp*)Cl 2 Pnfx-Cu(phen)](NO 3 )·1.75(CH 3 OH)·0.75(H 2 O) ( 2 ), [Ir(η 5 -Cp*)Cl 2 Plfx-Cu(phen)](NO 3 )·1.3(H 2 O)·1.95(CH 3 OH) ( 3 ), [Ir(η 5 -Cp*)Cl 2 Psfx-Cu(phen)] (4 )) 衍生自氟喹诺酮类的磷化氢，即司帕沙星 (Hsfx)、环丙沙星 (Hcfx)、洛美沙星 (Hlfx) 和诺氟沙星 (Hnfx)，已作为可能的抗癌化疗药物进行了合成和研究。所有化合物均已通过电喷雾电离质谱 (ESI-MS)、多种光谱方法（即IR、荧光和电子顺磁共振
• Structure and magnetic behaviour of a novel alternating one-dimensional chain compound {[Cu(phen)(μ1,1-N3)]2(μ-ta)}n
  作者：Licun Li*、Daizheng Liao、Zonghui Jiang*、Shiping Yan

  DOI：10.1016/s0277-5387(01)00705-7

  日期：2001.4

  Abstract A new one-dimensional alternating chain compound [Cu(phen)(μ1,1-N3)]2(μ-ta)}n (phen=1,10-phenanthroline, ta=terephthalato dianion) has been prepared and characterised by X-ray crystallography and magnetic measurements. The structure consists of copper chains in which the copper(II) ions are alternatively bridged by terephalato and double end-on azido bridges. In the temperature range 4–300

  摘要制备并表征了一种新的一维交替链化合物[Cu（phen）（μ1,1-N3）] 2（μ-ta）} n（phen = 1,10-菲咯啉，ta =对苯二甲酸双阴离子）并对其进行了表征通过X射线晶体学和磁性测量。该结构由铜链组成，其中铜（II）离子通过对苯二甲酸和双端叠氮基桥交替连接。在4–300 K的温度范围内，可以将标题化合物的可变温度磁化率建模为二聚体铜，其中交换相互作用为铁磁性。
• Synthetic study of the ternary copper(II)/maleamate(-1)/1,10-phenanthroline reaction system: Mononuclear, dinuclear and polymeric complexes
  作者：Katerina N. Lazarou、Spyros P. Perlepes、Vassilis Psycharis、Catherine P. Raptopoulou

  DOI：10.1016/j.poly.2008.04.005

  日期：2008.6

  The use of the maleamic acid (H2L)/1,10-phenathroline "blend" in copper(II) chemistry has yielded mononuclear and dinuclear complexes, and one coordination polymer. The chemical and structural identity of the products depends on the solvent, the absence or presence of external hydroxides in the reaction mixtures, the nature of the inorganic anion present in the copper(II) starting material and the molar ratio of the reactants. The maleamato(-1) complexes [Cu-2(HL)(3)(phen)(2)](NO3) (2, 7), [Cu(HL)(phen)(2)](OH) (3), [Cu(HL)(2)(phen)] (4) and [Cu(HL)(NO3)(phen)](n) (8) have been prepared and structurally characterized. The dinuclear cations 2 and 7 are structurally similar to the cation of complex [Cu-2(HL)(3)(phen)(2)](ClO4) (1) which was previously communicated. The maleamato(-1) ligand adopts a variety of coordination modes in the above complexes, ranging from the familiar syn,syn eta(1):eta(1):mu(2) bridging mode and the rare monoatomic bridging (eta(1):mu(2)) mode in the structures of 2 and 7, to the terminal monodentate in the structures of 3 and 4. Complex 8 is a 1D, zigzag coordination polymer in which the carboxylato group of the HL- ligand is asymmetrically coordinated to two Cu-II ions adopting the syn,anti eta(1):eta(1):mu(2) mode; the amide O atom is also coordinated, thus forming an unusual 7-membered chelating ring. The crystal structures of the complexes are stabilized by a variety of H-bonding patterns which lead to interesting supramolecular architectures. Characteristic IR bands of the complexes are discussed in terms of the known structures, and the coordination modes of the HL- ligand. (C) 2008 Elsevier Ltd. All rights reserved.