N¹-((6-methoxynaphthalen-2-yl)methyl)-N⁴-(4-(piperazin-1yl)butyl)butane-1,4-diamine tetrahydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N¹-((6-methoxynaphthalen-2-yl)methyl)-N⁴-(4-(piperazin-1yl)butyl)butane-1,4-diamine tetrahydrochloride
• 英文别名: N'-[(6-methoxynaphthalen-2-yl)methyl]-N-(4-piperazin-1-ylbutyl)butane-1,4-diamine;hydrochloride
• 化学式: C₂₄H₃₈N₄O*4ClH
• 分子量: 544.436
• InChiKey: DALSQLMKJSNLGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.42
• 重原子数：
  30
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  48.6
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  6-甲氧基-2-萘甲醛 在 盐酸 、 sodium tetrahydroborate 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 N¹-((6-methoxynaphthalen-2-yl)methyl)-N⁴-(4-(piperazin-1yl)butyl)butane-1,4-diamine tetrahydrochloride
  参考文献：
  名称：

  Synthesis and bioevaluation of N-(arylalkyl)-homospermidine conjugates

  摘要：

  N'-(Arylalkyl)homospermidines (Ic-1f) and terminally piperazine-substituted homospermidine conjugates (2a-2e) were synthesized and evaluated for cytotoxicity in mouse leukemia L 1210, alpha-difluorometliylornithine (DFMO)-treated L 12 10, melanoma B 16, spermidine (SPD)-treated B 16, and HeLa cell lines. Results demonstrated that homospermidine was a more effective vector than piperazine-substituted homospermidine in ferrying diverse arenes into cells via the polyamine transporter. The leading compound, 9-anthracenemethyl-homospermidine (1a), was shown to induce apoptosis in B16 cells and IL-3 dependent FL5.12A proB cells. The novel conjugate 4-biphenylmethyl-homospermidine (1e) could also induce apoptosis. However, it exhibited different effect on the cell cycle of B16 cells compared to la. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.06.009

文献信息

• Synthesis and bioevaluation of N-(arylalkyl)-homospermidine conjugates
  作者：Songqiang Xie、Pengfei Cheng、Guangchao Liu、Yuangfang Ma、Jin Zhao、Mounir Chehtane、Annette R. Khaled、Otto Phanstiel、Chaojie Wang

  DOI：10.1016/j.bmcl.2007.06.009

  日期：2007.8

  N'-(Arylalkyl)homospermidines (Ic-1f) and terminally piperazine-substituted homospermidine conjugates (2a-2e) were synthesized and evaluated for cytotoxicity in mouse leukemia L 1210, alpha-difluorometliylornithine (DFMO)-treated L 12 10, melanoma B 16, spermidine (SPD)-treated B 16, and HeLa cell lines. Results demonstrated that homospermidine was a more effective vector than piperazine-substituted homospermidine in ferrying diverse arenes into cells via the polyamine transporter. The leading compound, 9-anthracenemethyl-homospermidine (1a), was shown to induce apoptosis in B16 cells and IL-3 dependent FL5.12A proB cells. The novel conjugate 4-biphenylmethyl-homospermidine (1e) could also induce apoptosis. However, it exhibited different effect on the cell cycle of B16 cells compared to la. (c) 2007 Elsevier Ltd. All rights reserved.