palladium-barium carbonate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: palladium-barium carbonate
• 英文别名: Pd-BaCO3；barium(2+);palladium;carbonate
• 化学式: Ba*CO₃*Pd
• 分子量: 303.759
• InChiKey: XGKBXQRHLKHDLF-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -2.83
• 重原子数：
  6
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  palladium-barium carbonate 、 葡萄糖 以 乙酸甲酯 、 水 为溶剂， 生成 葡萄糖酸内酯
  参考文献：
  名称：

  Process for producing glucona-delta-lactone from glucose

  摘要：

  一种从葡萄糖中制备葡萄糖酸δ-内酯的方法，包括将葡萄糖与分子氧在有机溶剂和钯或铂催化剂存在下接触。该方法可选包括酸处理。

  公开号：

  US04256645A1

文献信息

• Tricyclic compound having spiro union
  申请人：——

  公开号：US20030045520A1

  公开（公告）日：2003-03-06

  This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which exhibits strong anticoagulation action. 1 The invention also relates to a pharmacophore which was derived from the compound and is useful in molecular designing of the FXa inhibitor.

  本发明涉及具有以下式（I）所表示的螺联结的三环化合物或其盐，该化合物可用作药物，特别是作为激活的血液凝血因子X的抑制剂，可经口给药，具有强烈的抗凝作用。该发明还涉及从该化合物衍生的药效团，可用于FXa抑制剂的分子设计。
• Processes for the preparation of 4-substituted benzopyran derivatives
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：US06455708B1

  公开（公告）日：2002-09-24

  Starting, for example, from 1-fluoro-2-fluoromethyl-3-butyn-2-yl 4-trifluoromethylphenyl; ether, N-(2-cyanoethyl)-5-fluoro-4-fluoromethyl-4-(4-trifluoromethylphenoxy)-2-pentynamide is produced and then cyclized to synthesize 2,2-bis(fluoromethyl)-N-(2-cyanoethyl)-6-trifluoromethyl-2H-1-benzopyran-4-carboxamide. The invention processes for producing 4-substituted benzopyran derivatives involve fewer steps, feature greater safety and allow for easier purification than the prior art processes.

  例如，从1-氟-2-氟甲基-3-丁炔-2-基-4-三氟甲基苯基醚开始；产生N-(2-氰乙基)-5-氟-4-氟甲基-4-(4-三氟甲基苯氧基)-2-戊炔酰胺，然后环化合成2,2-双(氟甲基)-N-(2-氰乙基)-6-三氟甲基-2H-1-苯并吡喃-4-甲酰胺。本发明的生产4-取代苯并吡喃衍生物的工艺步骤比现有技术的工艺步骤更少，具有更高的安全性，并且比以往更容易纯化。
• Cyanobiphenyl derivatives
  申请人：Teijin Limited

  公开号：US06538137B1

  公开（公告）日：2003-03-25

  Intermediates represented by the following formula: (wherein R1 is a hydrogen atom, an alkyl group, an aryl group, an aralkyl group or the like; X is a carboxyl group, an alkoxycarbonyl group, an aryloxycarbonyl group, an aralkoxycarbonyl group, a formyl group, —CH2—Y, —CHZ1Z2, —CH(OR4)OR5 or the like), in the synthesis of biphenylamidine derivatives to be used as inhibitors for an activated blood coagulation factor X, and a process for preparing the same.

  以下公式代表的中间体：（其中R1为氢原子、烷基、芳基、芳基烷基或类似物；X为羧基、烷氧羰基、芳氧羰基、芳基烷氧羰基、甲酰基、—CH2—Y、—CHZ1Z2、—CH(OR4)OR5或类似物），用于合成作为激活的血液凝血因子X抑制剂的联苯胺衍生物，并制备该物质的方法。
• Cephalosporin isocyanates
  申请人：American Home Products Corporation

  公开号：US03932391A1

  公开（公告）日：1976-01-13

  Novel penicillin and cephalosporin isocyanates are described which are useful intermediates for reaction with compounds containing an active hydrogen to produce penicillin and cephalosporin derivatives having activity against gram positive and/or gram negative bacteria.

  描述了一种新型的青霉素和头孢菌素异氰酸酯，它们是有用的中间体，可与含有活性氢的化合物反应，产生对革兰氏阳性和/或革兰氏阴性细菌具有活性的青霉素和头孢菌素衍生物。
• Purification of penicillin derivative
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：US04313875A1

  公开（公告）日：1982-02-02

  Crude 6-[D-2-(D-2-amino-3-N-methylcarbamoyl-propionamido)-2-p-hydroxyphenylaceta mido]penicillanic acid can be purified by the steps of: (A) contacting an aqueous solution of 6-[D-2-(D-2-amino-3-N-methylcarbamoyl-propionamido)-2-p-hydroxyphenylaceta mido]-penicillanic acid with a nonpolar, macroporous styrenedivinylbenzyl copolymer adsorption resin to adsorb 6-[D-2-(D-2-amino-3-N-methylcarbamoyl-propionamido)-2-p-hydroxyphenylaceta mido]penicillanic acid on the resin, (B) eluting the adsorbed 6-[D-2-(D-2-amino-3-N-methylcarbamoyl-propionamido)-2-p-hydroxyphenylaceta mido]penicillanic acid with water or a mixture of water and a water-miscible organic solvent, and then (C) isolating pure 6-[D-2-(D-2-amino-3-N-methylcarbamoyl-propionamido)-2-p-hydroxyphenylaceta mido]penicillanic acid from the eluates.

  粗6-[D-2-(D-2-氨基-3-N-甲基羧酰基丙氨酰)-2-p-羟基苯乙酰氨基]青霉烷酸可以通过以下步骤纯化：（A）将6-[D-2-(D-2-氨基-3-N-甲基羧酰基丙氨酰)-2-p-羟基苯乙酰氨基]青霉烷酸的水溶液与非极性的大孔苯乙烯-二乙烯基苯共聚物吸附树脂接触，将6-[D-2-(D-2-氨基-3-N-甲基羧酰基丙氨酰)-2-p-羟基苯乙酰氨基]青霉烷酸吸附在树脂上，（B）用水或水溶性有机溶剂混合物洗脱吸附的6-[D-2-(D-2-氨基-3-N-甲基羧酰基丙氨酰)-2-p-羟基苯乙酰氨基]青霉烷酸，然后（C）从洗脱物中分离纯的6-[D-2-(D-2-氨基-3-N-甲基羧酰基丙氨酰)-2-p-羟基苯乙酰氨基]青霉烷酸。